Results 21 to 30 of about 991,955 (291)

Novel Delivery System Used for Oral Bioavailability Enhancement of Poorly Water Soluble Drugs [PDF]

, 2020
Majority of the drugs used for the treatment of various diseases are administered by oral route using conventional delivery. The major drawback of the oral administration is the poor bioavailability due to the poor water solubility, chemical stability ...
Lakavath, Sunil Kumar, Sunil Kumar Lakavath   +1 more
core   +1 more source

Preparation and optimization of microemulsion of rosuvastatin calcium

Journal of Pharmacy and Bioallied Sciences, 2012
Due to very less bioavailability (20%) of Rosuvastatin calcium, an attempt was made to develop and optimize microemulsion formulation. Capmul MCM, Tween 20 and PEG 400 were selected as oil, surfactant and cosurfactant respectively as the drug is having ...
B Zalak Patel, S Kruti Patel, S Ankit Shah, I Naazneen Surti   +3 more
doaj   +1 more source

Solubility enhancement (Solid Dispersions) novel boon to increase bioavailability [PDF]

, 2019
The solubility of a solute is the maximum quantity of solute that can dissolve in a certain quantity of solvent or quantity of solution at a specified temperature.
Pawar, Sandip R., Barhate, Shashikant D.
core   +1 more source

Folate bioavailability [PDF]

, 2009
An inadequate folate status is associated with increased risk of anaemia and neural tube defects. In many countries a folate intake below recommendations has been reported for women in childbearing age.
Öhrvik, Veronica
core   +1 more source

Enhancing the bioavailability of resveratrol by combining it with piperine [PDF]

Molecular Nutrition & Food Research, 2011
AbstractScope:Resveratrol (3,5,4′‐trihydroxystilbene) is a phytoalexin shown to possess a multitude of health‐promoting properties in pre‐clinical studies. However, the poor in vivo bioavailability of resveratrol due to its rapid metabolism is being considered as a major obstacle in translating its effects in humans.
Jeremy J, Johnson, Minakshi, Nihal, Imtiaz A, Siddiqui, Cameron O, Scarlett, Howard H, Bailey, Hasan, Mukhtar, Nihal, Ahmad   +6 more
openaire   +2 more sources

VARIOUS TECHNIQUES OF BIOAVAILABILITY ENHANCEMENT: A REVIEW [PDF]

, 2016
Bioavailability is defined as the rate and extent (amount) of absorption of unchanged drug from its dosage form. It is one of the important parameters which are required to achieve optimal concentration of drug in systemic circulation to show a ...
Khan, Azhar Danish, Singh, Lubhan
core   +1 more source

Enhancement of oral bioavailability of cyclosporine A: comparison of various nanoscale drug-delivery systems [PDF]

, 2014
Kai Wang,1–3 Jianping Qi,1 Tengfei Weng,1,2 Zhiqiang Tian,1 Yi Lu,1 Kaili Hu,4 Zongning Yin,2 Wei Wu1 1School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery of Ministry of Education, Shanghai, People’s Republic of China;
S. EL-FEKY, GINA, Ali, Ahmed M. Abdelhaleem, A. GALIL, RAMI, O. AMMAR, HUSSEIN, Lu Y, Ammar, Hussein O., Qi JP, Wang K, M. ABDELHALEEM AL, AHMED, Yin ZN, Dawood, Rami A. Galil, Tian ZQ, Hu KL, Wu W, Weng TF, El-feky, Gina S.   +15 more
core   +1 more source

Cationic Curcumin Nanocrystals Liposomes for Improved Oral Bioavailability: Formulation Development, Optimization, In Vitro and In Vivo Evaluation

Pharmaceutics
Curcumin, a naturally occurring poorly water-soluble polyphenol with a broad spectrum, is a typical BCS IV drug. The objective of this study was to develop curcumin nanocrystals liposomes with the aim of improving bioavailability.
Xiang Cheng, Xiaoran Han, Jia Si, Cong Dong, Zhongjuan Ji, Shicong Zhao, Xiangting Wu, Haiyan Li, Xiangqun Jin   +8 more
doaj   +1 more source

Cyclodextrin-Based Drug Delivery Systems for Depression: Improving Antidepressant Bioavailability and Targeted Central Nervous System Delivery

Pharmaceutics
Cyclodextrin (CD)-based drug delivery systems have emerged as a promising strategy to overcome limitations commonly encountered in antidepressant therapy, including low bioavailability, poor solubility, and suboptimal penetration of the blood–brain ...
Renata Maria Văruț, Alin Iulian Silviu Popescu, Simina Gaman, Carmen Elena Niculescu, Adrian Ștefan Niculescu, Dalia Dop, Mioara Desdemona Stepan, Nina Ionovici, Cristina Elena Singer, Cristina Popescu   +9 more
doaj   +1 more source

Nanoporous smartPearls for dermal application – Identification of optimal silica types and a scalable production process as prerequisites for marketed products

Beilstein Journal of Nanotechnology, 2019
smartPearls are a dermal delivery system for poorly soluble active agents, consisting of nanoporous silica particles loaded with a long-term stable, amorphous active agent in its mesopores (2–50 nm).
David Hespeler, Sanaa El Nomeiri, Jonas Kaltenbach, Rainer H. Müller   +3 more
doaj   +1 more source