Results 81 to 90 of about 54,975 (247)

Rewiring NADH Metabolism Through NQO1‐Mediated Redox Cycling for Targeted Follicular Lymphoma Therapy

Advanced Science, EarlyView.
ABSTRACT Follicular lymphoma (FL) remains an incurable B‐cell malignancy with high relapse rates, and conventional therapies are often limited by significant toxicity, highlighting the need for novel treatments. We identified that FL exhibits markedly low expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a key enzyme required for activating ...
Jinxing Zhang, Ziqi Wang, Ye Weng, Yulin Fu, Yuelong Jiang, Beilin Zhuang, Wenzi Zeng, Xiangchun Zhang, Bing Xu, Jie Zha, Hongjun Zhuang   +10 more
wiley   +1 more source

Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs. [PDF]

Life (Basel), 2023
Kumari L, Choudhari Y, Patel P, Gupta GD, Singh D, Rosenholm JM, Bansal KK, Kurmi BD.   +7 more
europepmc   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Overview of Metabolism and Bioavailability Enhancement of Polyphenols

, 2016
A proper diet is one of major factors contributing to good health and is directly related to general condition of the organism. Phenolic compounds are abundant in foods and beverages (fresh and processed fruits and vegetables, leguminous plants, cereals,
Anna Janecka (1601698), Urszula Lewandowska (1341897), Elżbieta Hrabec (1868929), Karolina Szewczyk (1868926), Sylwia Gorlach (1868932)   +4 more
core   +1 more source

Hydrothermal Humification of Biomass for Circular Carbon Management in Sustainable Agro‐Ecosystems

Advanced Science, EarlyView.
This article provides a comprehensive overview of biomass hydrothermal humification for building sustainable agro‐ecosystems. It examines the chemical transformation mechanisms and the functional benefits of the produced humic acids in soil remediation.
Ziyun Liu, Zonglu Yao, Yuanhui Zhang, Huiyan Zhang, Lixin Zhao   +4 more
wiley   +1 more source

Nanovesicles-Mediated Drug Delivery for Oral Bioavailability Enhancement. [PDF]

Int J Nanomedicine, 2022
Ren Y, Nie L, Zhu S, Zhang X.
europepmc   +1 more source

CD44‐Targeting Hydroxyapatite Nanoparticles (HAP) Induce Mitochondrial Dysfunction‐Driven PANoptosis and Immunogenic Cell Death (ICD) via Ca Overload in Colorectal Cancer

Advanced Science, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao, Yuxuan Yang, Haosen Qiu, Jia Yang, Hao Liang, Zhaojun Jiang, Xiao Tong, Yongying Li, Qunfeng Huang, Jiaming Wu, Tian Lin, Jiang Yu, Min Liang   +12 more
wiley   +1 more source

Progress in Antimelanoma Research of Natural Triterpenoids and Their Derivatives: Mechanisms of Action, Bioavailability Enhancement and Structure Modifications. [PDF]

Molecules, 2023
Grudzińska M, Stachnik B, Galanty A, Sołtys A, Podolak I.   +4 more
europepmc   +1 more source

Enhancing the Bioavailability of Poorly Soluble Drugs

Pharmaceutics
The poor aqueous solubility of drugs is such a frequent challenge to drug absorption, bioavailability, and drug delivery that it is occasionally spoken about as an “unwritten rule” in drug product development [...]
openaire   +3 more sources

Trophic Diversity in Duckweed: Mixotrophy, More Than the Sum of its Extremes

Advanced Science, EarlyView.
In the context of rising DOC in aquatic environments, mixotrophic duckweed may impact carbon cycling by acting as either a carbon sink, as they absorb CO2 through photosynthesis, or a carbon source, as they release CO2 through respiration of absorbed DOC, which depends on DOC concentration, light availability, temperature, and other environmental ...
Zuoliang Sun, Yan Chen, Fajun Li, Xuyao Zhao, Qingxiang Han, Hongwei Hou   +5 more
wiley   +1 more source