Results 111 to 120 of about 220,549 (336)

Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression [PDF]

, 2019
Many workers are daily exposed to occupational agents like gases/fumes, mineral dust or biological dust, which could induce adverse health effects. Epigenetic mechanisms, such as DNA methylation, have been suggested to play a role.
't Hoen, Peter-Bram, Amin, Najaf, Arindrarto, Wibowo, Beekman, Marian, Boezen, H Marike, Bonder, Marc Jan, Boomsma,, Dorret I, Bot, Jan, Brusselle, Guy, de Jong, Kim, de Vries, Maaike, Deelen, Joris, Deelen, Patrick, Franke, Lude, Heijmans, Bastiaan T, Hoen, Peter ACT, Hofman, Bert A, Hottenga, Jouke J, Isaacs, Aaron, Jansen, Rick, Jhamai, P Mila, Kielbasa, Szymon M, Kromhout, Hans, La Bastide-van Gemert, Sacha, Lahousse, Lies, Lakenberg, Nico, Luijk, Rene, Mei, Hailiang, Moed, Matthijs, Nedeljkovic, Ivana, Nooren, Irene, Pool, Rene, Postma, Dirkje S, Schalkwijk, Casper G, Slagboom, P Eline, Stehouwer, Coen DA, Suchiman, H Eka D, Swertz, Morris A, Terzikhan, Natalie, Tigchelaar, Ettje E, Uitterlinden, Andre G, van den Berg, Leonard H, van Der Breggen, Ruud, van Der Kallen, Carla JH, van Der Plaat, Diana, van Diemen, Cleo C, van Dijk, Freerk, van Dongen, Jenny, van Duijn, Cornelia M, van Galen, Michiel, van Greevenbroek, Marleen MJ, van Heemst, Diana, van Iterson, Maarten, van Meurs, Joyce, van Rooij, Jeroen, van Zwet, Erik W, Vant Hof, Peter, Veldink, Jan H, Verbiest, Michael, Verkerk, Marijn, Vermaat, Martijn, Vermeulen, Roel CH, Vonk, Judith M, Wijmenga, Cisca, Zhernakova, Dasha V, Zhernakova, Sasha   +65 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The Bio-Objectification of Umbilical Cord Blood: Socio-Economic and Epistemic Implications of Biobanking

Tecnoscienza, 2014
In the current biomedical literature Umbilical Cord Blood (UCB) is considered a valid source of hematopoietic stem cells for hemopoiesis reconstitution. The acknowledgment of the potential of UCB for transplants prompted the transformation of this human ...
Lorenzo Beltrame
doaj   +1 more source

Genetic susceptibility loci for cardiovascular disease and their impact on atherosclerotic plaques [PDF]

, 2018
Background: Atherosclerosis is a chronic inflammatory disease in part caused by lipid uptake in the vascular wall, but the exact underlying mechanisms leading to acute myocardial infarction and stroke remain poorly understood. Large consortia identified
Asselbergs, Folkert W, Björkegrenn, Johan L.M, de Bakker, Paul I.W, de Borst, Gert J., den Ruijter, Folkert W, Dichgans, Martin, Erdmann, Jeanette, Ford, Ian, Foroughi Asl, Hassan, Haitjema, Saskia, Hedin, Ulf, Malik, Rainer, Mokry, Michal, Pasterkamp, Gerard, Paulsson-Berne, Gabrielle, Perisic, Ljubica, Samani, Nilesh J, Sattar, Naveed, Schunkert, Heribert, Siemelink, Marten A., Stott, David J., van der Laan, Sander W., van Setten, Jessica, Worrall, Bradford B   +23 more
core   +2 more sources

Large Scale Population Assessment of Physical Activity Using Wrist Worn Accelerometers: The UK Biobank Study

PLoS ONE, 2017
Background Physical activity has not been objectively measured in prospective cohorts with sufficiently large numbers to reliably detect associations with multiple health outcomes. Technological advances now make this possible.
A. Doherty, D. Jackson, Nils Y. Hammerla, T. Plötz, P. Olivier, M. Granat, Tom White, V. V. van Hees, M. Trenell, C. Owen, S. Preece, Rob Gillions, Simon Sheard, T. Peakman, S. Brage, N. Wareham   +15 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Evaluation of RNA purification methods by using different blood stabilization tubes: identification of key features for epidemiological studies

BMC Research Notes, 2020
Objective Peripheral blood is the most promising source of RNA biomarkers for diagnostic and epidemiological studies, because the presence of disease and prognostic information is reflected in the gene expression pattern.
J. A. Carrillo-Ávila, R. de la Puente, P. Catalina, J. D. Rejón, L. Espín-Vallejo, V. Valdivieso, R. Aguilar-Quesada   +6 more
doaj   +1 more source

LAS: a software platform to support oncological data management [PDF]

, 2012
The rapid technological evolution in the biomedical and molecular oncology fields is providing research laboratories with huge amounts of complex and heterogeneous data.
A El Akadi, A Tolopko, Alberto Grand, Alessandro Fiori, Andrea Bertotti, Elena Baralis, H Maier, J Wang, K Kuhn, S Clément, S Haquin, TR Golub   +11 more
core   +1 more source

APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort

medRxiv, 2020
The novel respiratory disease COVID-19 produces varying symptoms, with fever, cough, and shortness of breath being common. In older adults, we found that pre-existing dementia is a major risk factor (OR = 3.07, 95% CI: 1.71 to 5.50) for COVID-19 ...
Chia-Ling Kuo, L. Pilling, J. Atkins, Jane A. H. Masoli, J. Delgado, G. Kuchel, D. Melzer   +6 more
semanticscholar   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source