Results 11 to 20 of about 220,549 (336)
Management of biobanking for medical genetics research
Кардиоваскулярная терапия и профилактика, 2022 Biobanking is one of the most important elements of the modern infrastructure for biomedical research. Organization of a biobank on the basis of the N. P.
V. Yu. Tabakov
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Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis [PDF]
, 2020 Background A non-invasive method to grade the severity of steatohepatitis and liver fibrosis is magnetic resonance imaging (MRI) based corrected T1 (cT1).
Banerjee, R +25 more
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Exome sequencing and analysis of 454,787 UK Biobank participants
Nature, 2021 A major goal in human genetics is to use natural variation to understand the phenotypic consequences of altering each protein-coding gene in the genome. Here we used exome sequencing1 to explore protein-altering variants and their consequences in 454,787
J. Backman +40 more
semanticscholar +1 more source
An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank
Nature Neuroscience, 2021 UK Biobank is a major prospective epidemiological study, including multimodal brain imaging, genetics and ongoing health outcomes. Previously, we published genome-wide associations of 3,144 brain imaging-derived phenotypes, with a discovery sample of 8 ...
Stephen M. Smith +6 more
semanticscholar +1 more source
Xiehe Yixue Zazhi, 2022 In recent years, the incidence of colorectal cancer in China has increased significantly. With the in-depth exploration of the mechanisms of colorectal cancer recurrence and metastasis, a biobank information system that can provide comprehensive ...
KONG Weiming +4 more
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Biobanks for genomics and genomics for biobanks [PDF]
Comparative and Functional Genomics, 2003 AbstractBiobanks include biological samples and attached databases. Human biobanks occur in research, technological development and medical activities. Population genomics is highly dependent on the availability of large biobanks. Ethical issues must be considered: protecting the rights of those people whose samples or data are in biobanks (information,
Cambon-Thomsen, Anne +3 more
openaire +5 more sources
A generalized linear mixed model association tool for biobank-scale data
Nature Genetics, 2021 Compared with linear mixed model-based genome-wide association (GWA) methods, generalized linear mixed model (GLMM)-based methods have better statistical properties when applied to binary traits but are computationally much slower.
Longda Jiang +3 more
semanticscholar +1 more source
Rare variant contribution to human disease in 281,104 UK Biobank exomes
Nature, 2021 Genome-wide association studies have uncovered thousands of common variants associated with human disease, but the contribution of rare variants to common disease remains relatively unexplored.
Quanli Wang +59 more
semanticscholar +1 more source
Cryopreservation of Sperm from an Endangered Snake with Tests of Post-Thaw Incubation in Caffeine
Animals, 2022 Cryopreservation of sperm to preserve the genetic diversity of declining populations is a promising technique to aid in the recovery of endangered species such as the Louisiana pinesnake (Pituophis ruthveni). However, this technique has been performed on
Mark R. Sandfoss +3 more
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Systemic inflammation markers and cancer incidence in the UK Biobank
European Journal of Epidemiology, 2021 Systemic inflammation markers have been linked to increased cancer risk and mortality in a number of studies. However, few studies have estimated pre-diagnostic associations of systemic inflammation markers and cancer risk.
T. Nøst +6 more
semanticscholar +1 more source