Results 21 to 30 of about 171,678 (355)

Developing automated methods for disease subtyping in UK Biobank: an exemplar study on stroke [PDF]

, 2021
Background Better phenotyping of routinely collected coded data would be useful for research and health improvement. For example, the precision of coded data for hemorrhagic stroke (intracerebral hemorrhage [ICH] and subarachnoid hemorrhage [SAH]) may be
Sudlow, Cathie L M; id_orcid, Allen, Naomi, the UK Biobank, Whiteley, William N; id_orcid, Rannikmäe, Rannikmäe, Cathie Sudlow, Kristiina Rannikmäe, Wu, H, Allen, N, Rannikmäe, K, Tominey, Steven, Honghan Wu, Steven Tominey, Rannikmae, Kristiina, Wu, Honghan, William Whiteley, Tominey, S, Sudlow, C, Sudlow, Cathie, Naomi Allen, Whiteley, W, UK Biobank, Whiteley, William   +22 more
core   +1 more source

Biobank data for studying the genetic architecture of osteoporosis and developing genetic risk scores

Кардиоваскулярная терапия и профилактика, 2022
Osteoporosis is a chronic systemic disease of the skeleton, characterized by a decrease in bone mass and an impairment of bone microarchitecture, which can lead to a decrease in bone strength and an increase in the risk of minor trauma fractures ...
E. A. Sotnikova, A. V. Kiseleva, A. N. Meshkov, A. I. Ershova, A. A. Ivanova, M. A. Kolchina, V. A. Kutsenko, I. A. Skripnikova, O. M. Drapkina   +8 more
doaj   +1 more source

Biobank as a key component of supporting research in phthisiology and infectious diseases

Кардиоваскулярная терапия и профилактика, 2022
Conducting fundamental and clinical research in the field of tuberculosis is an important step towards reducing related morbidity and mortality, but access to a sufficient number of high-quality samples required for research is an unsolved problem in ...
T. V. Umpeleva, D. V. Vakhrusheva, S. N. Skornyakov   +2 more
doaj   +1 more source

Modification effect of ideal cardiovascular health metrics on genetic association with incident heart failure in the China Kadoorie Biobank and the UK Biobank [PDF]

, 2021
Background Both genetic and cardiovascular factors contribute to the risk of developing heart failure (HF), but whether idea cardiovascular health metrics (ICVHMs) offset the genetic association with incident HF remains unclear. Objectives To investigate
Ran Tao, on behalf of the China Kadoorie Biobank Collaborative Group, Li, Liming, Canqing Yu, Huang, Tao, Tao Huang, Tao, Ran, Iona Y. Millwood, Robert Clarke, Pei, Pei, Du, Huaidong, Liming Li, Yu, Canqing, Robin G. Walters, Huaidong Du, Chen, Yiping, Yu Guo, Ling Yang, Guo, Yu, Zhengming Chen, Yang, Ruotong, Ruotong Yang, Millwood, Iona, Pei Pei, Millwood, Iona Y, Yiping Chen, Jun Lv, Junshi Chen, Walters, Robin G, Lv, Jun, Walters, Robin, Clarke, Robert, Ninghao Huang, Huang, Ninghao, Chen, Junshi, Yang, Ling, Chen, Zhengming   +36 more
core   +1 more source

Development of a biobank in the structure of scientific and diagnostic and treatment institutions and prospects for interregional integration

Кардиоваскулярная терапия и профилактика, 2022
The formation of biobanks in the structure of scientific and treatment and diagnostic institutions with prospects for interregional integration is a fundamental link in monitoring and predicting diseases of various origins, creating and testing highly ...
R. S. Kalinin, O. V. Goleva, R. A. Illarionov, V. V. Tsai, A. L. Mukomolova, Yu. E. Konstantinova, I. V. Markin, A. V. Krylov, N. V. Rogozina, M. K. Bekhtereva, M. S. Tyan, E. D. Orlova, M. Yu. Donnikov, L. V. Kovalenko, L. N. Kolbasin, A. S. Glotov, O. S. Glotov   +16 more
doaj   +1 more source

Management of biobanking for medical genetics research

Кардиоваскулярная терапия и профилактика, 2022
Biobanking is one of the most important elements of the modern infrastructure for biomedical research. Organization of a biobank on the basis of the N. P.
V. Yu. Tabakov
doaj   +1 more source

Construction and Management of Biobank Information System for Multi-center Colorectal Cancer Clinical Research

Xiehe Yixue Zazhi, 2022
In recent years, the incidence of colorectal cancer in China has increased significantly. With the in-depth exploration of the mechanisms of colorectal cancer recurrence and metastasis, a biobank information system that can provide comprehensive ...
KONG Weiming, LYU Wenwen, JIANG Jiayuan, FENG Tienan, YU Zhangsheng   +4 more
doaj   +1 more source

Atlas of plasma NMR biomarkers for health and disease in 118,461 individuals from the UK Biobank

Nature Communications, 2023
The authors report a systematic analyses of blood biomarkers for metabolism against the whole spectrum of diseases in 100,000 individuals and reveals a prominent role of numerous metabolic biomarkers as risk markers beyond heart disease and diabetes ...
H. Julkunen, A. Cichońska, M. Tiainen, H. Koskela, K. Nybo, Valtteri Mäkelä, Jussi Nokso-Koivisto, K. Kristiansson, M. Perola, V. Salomaa, P. Jousilahti, A. Lundqvist, A. Kangas, P. Soininen, J. Barrett, P. Würtz   +15 more
semanticscholar   +1 more source

Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts.

, 2023
Polygenic risk scores (PRSs) have been widely explored in precision medicine. However, few studies have thoroughly investigated their best practices in global populations across different diseases.
Wolford, Brooke N., Kerminen, S, Lo Faro, Valeria,, Läll, Kristi, Wang, Ying, Kanai, M, Uzunovic, J, Bhatta, L, Lopera, E, Sanna, Serena, Smoller, Jordan W., Zhou, W, Hveem, K, Gamazon, Eric R., Lo Faro, Valeria, Wolford, Brooke N, Surakka, I, Hveem, Kristian, Namba, Shinichi, Willer, C, Lo Faro, V, Sanna, S, Bhatta, Laxmi, Millwood, Iona, Martin, AR, Martin, Alicia R, Tsuo, Kristin, Uzunovic, Jasmina, Läll, K, Awadalla, Philip, Willer, Cristen, Okada, Yukinori, Hirbo, Jibril B., Smoller, Jordan W, Cox, Nancy J., Wu, Kuan-Han, Mägi, Reedik, Favé, Marie-Julie, Global Biobank Meta-analysis Initiative, Cox, NJ, Brumpton, Ben, Smoller, JW, Mägi, R, Murakami, Y, Hirbo, Jibril, Brumpton, Ben Michael, Brumpton, B, Tsuo, K, Gamazon, ER, Kerminen, Sini, Awadalla, P, Cox, Nancy J, Martin, Alicia R., Wang, Y, Okada, Y, Faro, Valeria Lo, Namba, S, Zhou, Wei, Deelen, P, Kanai, Masahiro, Deelen, Patrick, Gamazon, Eric R, Wu, K-H, Favé, M-J, Wolford, BN, Surakka, Ida, GBMI, ., Hirbo, J, Lopera, Esteban, Murakami, Yoshinori   +69 more
core   +2 more sources

Participation bias in the UK Biobank distorts genetic associations and downstream analyses

Nature Human Behaviour, 2023
While volunteer-based studies such as the UK Biobank have become the cornerstone of genetic epidemiology, the participating individuals are rarely representative of their target population.
T. Schoeler, Doug Speed, E. Porcu, N. Pirastu, J. Pingault, Z. Kutalik   +5 more
semanticscholar   +1 more source