Results 41 to 50 of about 191,359 (300)

Association between grip strength and diabetes prevalence in black, South Asian, and white European ethnic groups: a cross-sectional study of 418,656 UK Biobank participants [PDF]

, 2017
Aims: To quantify the extent to which ethnic differences in muscular strength might account for the substantially higher prevalence of diabetes in black and South-Asian compared with white European adults.
Celis-Morales, C.A., Gill, J.M.R., Mackay, D.F., Ntuk, U.E., Pell, J.P., Sattar, N.   +5 more
core   +1 more source

Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture. [PDF]

, 2019
SNP-heritability is a fundamental quantity in the study of complex traits. Recent studies have shown that existing methods to estimate genome-wide SNP-heritability can yield biases when their assumptions are violated.
Burch, Kathryn S, Hou, Kangcheng, Majumdar, Arunabha, Mancuso, Nicholas, Pasaniuc, Bogdan, Sankararaman, Sriram, Shi, Huwenbo, Wu, Yue   +7 more
core  

Sleep characteristics modify the association between genetic predisposition to obesity and anthropometric measurements in 119,679 UK Biobank participants [PDF]

, 2017
Background - Obesity is a multifactorial condition influenced by genetics, lifestyle and environment. Objective - To investigate whether the association between a validated genetic profile risk score for obesity (GPRS-obesity) with body mass index (BMI)
Bailey, Mark E.S., Biello, Stephany M., Celis-Morales, Carlos, Gill, Jason M.R., Guo, Yibing, Llamas, Daniel, Lyall, Donald M., Mackay, Daniel F., Pell, Jill P., Steell, Lewis, Ward, Joey   +10 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Validation of Self-reported Medical Condition in the Taiwan Biobank

Journal of Epidemiology
Background: This study aimed to validate self-reported medical conditions in the Taiwan Biobank (TWBB), in which participants were inquired about 30 disease conditions, by comparing them with claims records from Taiwan’s National Health Insurance (NHI ...
Chi-Shin Wu, Le-Yin Hsu, Chen-Yang Shen, Wei J. Chen, Shi-Heng Wang   +4 more
doaj   +1 more source

The impact of confounding on the associations of different adiposity measures with the incidence of cardiovascular disease: a cohort study of 296 535 adults of white European descent [PDF]

, 2018
Aims: The data regarding the associations of body mass index (BMI) with cardiovascular (CVD) risk, especially for those at the low categories of BMI, are conflicting. The aim of our study was to examine the associations of body composition (assessed by
Anderson, Jana, Celis-Morales, Carlos A., Gill, Jason M.R., Gray, Stuart R., Iliodromiti, Stamatina, Lyall, Donald M., Mackay, Daniel F., Nelson, Scott M., Pell, Jill P., Sattar, Naveed, Welsh, Paul   +10 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Biobank linked to SWEDEHEART quality registry—routine blood sample collection opens new opportunities for cardiovascular research

Upsala Journal of Medical Sciences, 2019
High-quality biobanking within routine health services, through the use of existing health-care practices and infrastructure, with respect to safety and integrity of patients in line with the Swedish Biobank Act, enables large-scale collection of ...
Tomasz Baron, Anna Beskow, Stefan James, Bertil Lindahl   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Association between active commuting and incident cardiovascular disease, cancer, and mortality: prospective cohort study [PDF]

, 2017
Objective: To investigate the association between active commuting and incident cardiovascular disease (CVD), cancer, and all cause mortality. Design: Prospective population based study. Setting: UK Biobank.
Anderson, Jana, Celis-Morales, Carlos A., Gill, Jason M.R., Guo, Yibing, Lyall, Donald M., Mackay, Daniel F., Maldonado, Reno, Pell, Jill P., Sattar, Naveed, Steell, Lewis, Welsh, Paul   +10 more
core   +1 more source