Results 61 to 70 of about 191,359 (300)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Importance of Human Faecal Biobanking: From Collection to Storage

Postępy Mikrobiologii
The freezing and storage conditions of faecal samples in biobanks influence the preservation of the integrity and stability of genetic material and play a crucial role in scientific and clinical research quality.
Lewandowska Izabela, Grzech Katarzyna, Krzysztoń-Russjan Jolanta   +2 more
doaj   +1 more source

How the world of biobanking is changing with artificial intelligence

Frontiers in Digital Health
Artificial Intelligence is increasingly shaping the practice of biobanking by influencing how biobanks evolve and operate, especially when it concerns their relationship to data.
Michaela Th. Mayrhofer, Michaela Th. Mayrhofer   +1 more
doaj   +1 more source

Large-scale Quality Control of Cardiac Imaging in Population Studies: Application to UK Biobank [PDF]

, 2019
In large population studies such as the UK Biobank (UKBB), quality control of the acquired images by visual assessment is unfeasible. In this paper, we apply a recently developed fully-automated quality control pipeline for cardiac MR (CMR) images to the
Bai, W., Glocker, B., Matthews, P. M., Oktay, O., Rueckert, D., Schuh, A., Suzuki, H., Tarroni, G.   +7 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

From Biobank to Bedside: A Pilot Study on Returning Medically Actionable BRCA1/2 Results in Qatar’s Precision Medicine Landscape

Biomedicines
Background: Hereditary breast and ovarian cancer is an inherited condition caused by pathogenic (P) or likely pathogenic (LP) variants in the BRCA1 and BRCA2 genes.
Salha Bujassoum Al Bader, Hind Habish, Hajer Almulla, Fatemeh Abbaszadeh, Mariem Sidenna, Tasnim Fadl, Mohamed Alvi, Marwa Eldeeb, Huda Farah, Amal Elfatih, Radja Messai Badji, Lotfi Chouchane, Nahla Afifi, Said Ismail, Reem Alsulaiman, Wadha Al-Muftah   +15 more
doaj   +1 more source

ARMC 5 Variants and Risk of Hypertension in Blacks: MH- GRID Study. [PDF]

, 2019
Background We recently found that ARMC 5 variants may be associated with primary aldosteronism in blacks. We investigated a cohort from the MH - GRID (Minority Health Genomics and Translational Research Bio-Repository Database) and tested the association
Berthon, Annabel, Davis, Adam R, Faucz, Fabio R, Gaye, Amadou, Gibbons, Gary H, Hannah-Shmouni, Fady, Lodish, Maya B, Stratakis, Constantine A, Zilbermint, Mihail   +8 more
core  

Self-Reported Facial Pain in UK Biobank Study : Prevalence and Associated Factors [PDF]

, 2014
Peer ...
Beasley, Marcus, Macfarlane, Gary J, MacFarlane, Tatiana   +2 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

A low-tech, cost-effective and efficient method for safeguarding genetic diversity by direct cryopreservation of poultry embryonic reproductive cells

eLife, 2022
Chickens are an important resource for smallholder farmers who raise locally adapted, genetically distinct breeds for eggs and meat. The development of efficient reproductive technologies to conserve and regenerate chicken breeds safeguards existing ...
Tuanjun Hu, Lorna Taylor, Adrian Sherman, Christian Keambou Tiambo, Steven J Kemp, Bruce Whitelaw, Rachel J Hawken, Appolinaire Djikeng, Michael J McGrew   +8 more
doaj   +1 more source