Results 61 to 70 of about 106,316 (267)

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Use of organotypic or three-dimensional systems with basic fibroblast growth factor for in vitro culture of immature collared peccary testicle

Reproduction and Fertility
The objective was to evaluate the effects of different culture systems and the addition of fibroblast growth factor (bFGF) during in vitro culture (IVC) of testicular tissue fragments from prepubertal collared peccaries. Testes from five individuals were
Ana Glória Pereira, Andréia Maria da Silva, Luana Grasiele Pereira Bezerra, Joana Letícia Cottin de Albuquerque, Gabriel Santos Costa Bezerra, Alexsandra Fernandes Pereira, Carlos Eduardo Bezerra de Moura, Pierre Comizzoli, Alexandre Rodrigues Silva   +8 more
doaj   +1 more source

The Bio-Objectification of Umbilical Cord Blood: Socio-Economic and Epistemic Implications of Biobanking

Tecnoscienza, 2014
In the current biomedical literature Umbilical Cord Blood (UCB) is considered a valid source of hematopoietic stem cells for hemopoiesis reconstitution. The acknowledgment of the potential of UCB for transplants prompted the transformation of this human ...
Lorenzo Beltrame
doaj   +1 more source

The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti, Sheena Waters, Adil Harroud, Pernilla Stridh, Ruth Dobson, Benjamin M. Jacobs   +5 more
wiley   +1 more source

Evaluation of RNA purification methods by using different blood stabilization tubes: identification of key features for epidemiological studies

BMC Research Notes, 2020
Objective Peripheral blood is the most promising source of RNA biomarkers for diagnostic and epidemiological studies, because the presence of disease and prognostic information is reflected in the gene expression pattern.
J. A. Carrillo-Ávila, R. de la Puente, P. Catalina, J. D. Rejón, L. Espín-Vallejo, V. Valdivieso, R. Aguilar-Quesada   +6 more
doaj   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

I6 passages : sur la reproduction d’une lignée de cellules souches embryonnaires humaines entre Israël et la France

Socio-anthropologie
The first French clinical trial using human embryonic stem cells for regenerative purposes was launched in 2014, using the I6 stem cell line that was imported from Israel.
Noémie Merleau-Ponty, Sigrid Vertommen, Michel Pucéat   +2 more
doaj   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Exploring Factors Underlying Poorly-Controlled Asthma in Adults by Integrating Phenotypes and Genotypes Associated with Obesity and Asthma: A Case-Control Study

Journal of Asthma and Allergy, 2023
Hung-Ling Huang,1– 3,* Ying-Jhen Huang,4,* Yi-Chi Chu,4 Chia-Wei Chen,5 Hsin-Chou Yang,5 Jing-Shiang Hwang,5 Chun-Houh Chen,5 Ta-Chien Chan4,6 1Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan; 2Division of Pulmonary and Critical Care ...
Huang HL, Huang YJ, Chu YC, Chen CW, Yang HC, Hwang JS, Chen CH, Chan TC   +7 more
doaj