Results 61 to 70 of about 147,982 (310)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Biobanking across the phenome - at the center of chronic disease research [PDF]

, 2013
Recognized public health relevant risk factors such as obesity, physical inactivity, smoking or air pollution are common to many non-communicable diseases (NCDs). NCDs cluster and co-morbidities increase in parallel to age.
Nicole M Probst-Hensch, Imboden, Medea, Medea Imboden, Probst-Hensch, Nicole M.   +3 more
core   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Biobank@VITO: Biobanking the General Population in Flanders

Frontiers in Medicine, 2020
During the last 15 years, VITO has established an infrastructure for biobanking a collection of biological samples from the general population in Flanders (Belgium). This biobank was set up to contribute to future, yet unspecified, research questions in the field of environment and health.
Rosette Van Den Heuvel, Elly Den Hond, Ann Colles, Vera Nelen, Karen Van Campenhout, Greet Schoeters   +5 more
openaire   +3 more sources

Inflammatory Bowel Disease (IBD)—A Textbook Case for Multi-Centric Banking of Human Biological Materials

Frontiers in Medicine, 2019
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory condition affecting mainly the gastro-intestinal tract with two main entities: Crohn's disease (CD) and ulcerative colitis (UC).
Isabelle Cleynen, Loes Linsen, Sare Verstockt, Bram Verstockt, Vera Ballet, Eline Vandeput, Gert Van Assche, Marc Ferrante, Marc Ferrante, Kristel Van Landuyt, Séverine Vermeire, Séverine Vermeire, Nadine Ectors   +12 more
doaj   +1 more source

Development of the myocite biobank: Cost-efficient model of public sector investigator-driven biobank for idiopathic inflammatory myositis

Indian Journal of Rheumatology, 2020
Background: Biobanking refers to the cryopreservation of the various biologic samples for future research. In the era of omics, biobanking has emerged as a vital process to aid research, more so for rare diseases.
R Naveen, Anamika Kumari Anuja, Mohit Kumar Rai, Vikas Agarwal, Latika Gupta   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Importance of Human Faecal Biobanking: From Collection to Storage

Postępy Mikrobiologii
The freezing and storage conditions of faecal samples in biobanks influence the preservation of the integrity and stability of genetic material and play a crucial role in scientific and clinical research quality.
Lewandowska Izabela, Grzech Katarzyna, Krzysztoń-Russjan Jolanta   +2 more
doaj   +1 more source

How the world of biobanking is changing with artificial intelligence

Frontiers in Digital Health
Artificial Intelligence is increasingly shaping the practice of biobanking by influencing how biobanks evolve and operate, especially when it concerns their relationship to data.
Michaela Th. Mayrhofer, Michaela Th. Mayrhofer   +1 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source