Results 61 to 70 of about 171,678 (355)

Lipoprotein(a) concentrations and incident atherosclerotic cardiovascular disease: new insights from a large national biobank

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Supplemental Digital Content is available in the text. Objective: Lp(a) (lipoprotein[a]) concentrations are associated with atherosclerotic cardiovascular disease (ASCVD), and new therapies that enable potent and specific reduction are in development. In
A. Patel, Minxian Wang, J. Pirruccello, P. Ellinor, Kenney Ng, S. Kathiresan, A. Khera   +6 more
semanticscholar   +1 more source

Commercialisation fears and preferred forms of governance: a mixed methods investigation to identify a trusted Australian genomics repository

Frontiers in Public Health
This study aimed to identify operating conditions and governance mechanisms that would help to facilitate trust in, and willingness to donate to, a hypothetical Australian national genomic repository for health research where commercial use of data is ...
Brad Elphinstone, Jarrod Walshe, Dianne Nicol, Mark Taylor   +3 more
doaj   +1 more source

Investigating the need for antibiotic supplementation to the extender used for semen cryopreservation in collared peccaries

Frontiers in Veterinary Science, 2022
The objective was to investigate the effects of semen freezing extender supplementation with antibiotics on bacterial load of semen samples, sperm functional and morphological metrics in the collared peccary.
Samara S. J. Moreira, Caio S. Santos, Thibério S. Castelo, Luana G. P. Bezerra, Érica C. G. Praxedes, Tayná M. Matos, João B. F. Souza-Junior, Francisco M. C. Feijó, Pierre Comizzoli, Alexandre R. Silva   +9 more
doaj   +1 more source

Access to Biobanks: Harmonization Across Biobank Initiatives [PDF]

Biopreservation and Biobanking, 2014
The current study investigates whether access arrangements relevant for biobanking contain clear information on key access conditions. It furthermore assesses the extent to which these access conditions are harmonized across biobank initiatives.A comparative analysis was conducted of access arrangements developed by 26 organizations, 36 biobank ...
Michiel, Verlinden, Herman, Nys, Nadine, Ectors, Isabelle, Huys   +3 more
openaire   +3 more sources

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Validation of Self-reported Medical Condition in the Taiwan Biobank

Journal of Epidemiology
Background: This study aimed to validate self-reported medical conditions in the Taiwan Biobank (TWBB), in which participants were inquired about 30 disease conditions, by comparing them with claims records from Taiwan’s National Health Insurance (NHI ...
Chi-Shin Wu, Le-Yin Hsu, Chen-Yang Shen, Wei J. Chen, Shi-Heng Wang   +4 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Pan-UK Biobank GWAS improves discovery, analysis of genetic architecture, and resolution into ancestry-enriched effects

medRxiv
Large biobanks, such as the UK Biobank (UKB), enable massive phenome by genome-wide association studies that elucidate genetic etiology of complex traits.
K. Karczewski, R. Gupta, M. Kanai, W. Lu, K. Tsuo, Y. Wang, R. Walters, P. Turley, S. Callier, N. Baya, D. S. Palmer, J. Goldstein, G. Sarma, M. Solomonson, N. Cheng, S. Bryant, C. Churchhouse, C. Cusick, T. Poterba, J. Compitello, D. King, W. Zhou, C. Seed, H. Finucane, M. Daly, B. Neale, E. Atkinson, A. Martin   +27 more
semanticscholar   +1 more source

Egy konkrét biobank alkalmazás megvalósítása Java technológiával [PDF]

, 2011
A dolgozatban egy konkrét biobank alkalmazás létrehozásához szükséges technológiák, eszközök kerülnek bemutatásra. Ismertetésre kerülnek továbbá a hozott döntések ok-okozati kérdései is, illetve az, hogy az adott technológiák, eszközök milyen céllal ...
Nagy, István Zoltán
core  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source