Results 71 to 80 of about 171,678 (355)

Ethics and biobanks [PDF]

British Journal of Cancer, 2008
Biobank research has been the focus of great interest of scholars and regulatory bodies who have addressed different ethical issues. On the basis of a review of the literature it may be concluded that, regarding some major themes in this discussion, a consensus seems to emerge on the international scene after the regular exchange of arguments in ...
openaire   +2 more sources

Multi-biobank Mendelian randomization analyses identify opposing pathways in plasma low-density lipoprotein-cholesterol lowering and gallstone disease

European Journal of Epidemiology
Plasma low-density lipoprotein (LDL)-cholesterol is positively associated with coronary artery disease risk while biliary cholesterol promotes gallstone formation.
BM Guoyi Yang, PhD Amy M Mason, PhD Dipender Gill, PhD Mary Schooling, PhD Stephen Burgess   +4 more
semanticscholar   +1 more source

Accurate rare variant phasing of whole-genome and whole-exome sequencing data in the UK Biobank

bioRxiv, 2022
Phasing involves distinguishing the two parentally inherited copies of each chromosome into haplotypes. Here, we introduce SHAPEIT5, a new phasing method that quickly and accurately processes large sequencing datasets and applied it to UK Biobank (UKB ...
R. Hofmeister, D. Ribeiro, S. Rubinacci, O. Delaneau   +3 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Uppsala Clinical Research Center—development of a platform to promote national and international clinical science

Upsala Journal of Medical Sciences, 2019
Uppsala Clinical Research Center (UCR) is a non-profit organization that provides service for clinical research aiming for development and improvement of health care in Sweden and worldwide. UCR was started in 2001 with the ambition to shift the focus of
Lars Wallentin, Bertil Lindahl
doaj   +1 more source

Development of the myocite biobank: Cost-efficient model of public sector investigator-driven biobank for idiopathic inflammatory myositis

Indian Journal of Rheumatology, 2020
Background: Biobanking refers to the cryopreservation of the various biologic samples for future research. In the era of omics, biobanking has emerged as a vital process to aid research, more so for rare diseases.
R Naveen, Anamika Kumari Anuja, Mohit Kumar Rai, Vikas Agarwal, Latika Gupta   +4 more
doaj   +1 more source

Prospective study design and data analysis in UK Biobank

Science Translational Medicine
Population-based prospective studies, such as UK Biobank, are valuable for generating and testing hypotheses about the potential causes of human disease.
Naomi E. Allen, Ben Lacey, D. A. Lawlor, Jill P. Pell, John Gallacher, L. Smeeth, P. Elliott, P. Matthews, R. Lyons, Anthony D. Whetton, Anneke Lucassen, M. Hurles, Michael Chapman, A. Roddam, N. Fitzpatrick, Anna L. Hansell, Rebecca Hardy, R. Marioni, Valerie B. O’Donnell, Julie Williams, Cecilia M. Lindgren, Mark Effingham, J. Sellors, John Danesh, R. Collins   +24 more
semanticscholar   +1 more source

Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank

bioRxiv, 2017
UK Biobank is a large-scale prospective epidemiological study with all data accessible to researchers worldwide. It is currently in the process of bringing back 100,000 of the original participants for brain, heart and body MRI, carotid ultrasound and ...
F. Alfaro-Almagro, M. Jenkinson, N. Bangerter, J. Andersson, L. Griffanti, G. Douaud, S. Sotiropoulos, S. Jbabdi, Moisés Hernández-Fernández, Emmanuel Vallée, D. Vidaurre, Matthew A. Webster, P. McCarthy, C. Rorden, Alessandro Daducci, D. Alexander, Hui Zhang, I. Dragonu, P. Matthews, K. Miller, Stephen M. Smith   +20 more
semanticscholar   +1 more source

The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions

Nature Communications, 2020
UK Biobank is a population-based cohort of half a million participants aged 40–69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world’s largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to ...
T. Littlejohns, J. Holliday, L. Gibson, Steve Garratt, N. Oesingmann, F. Alfaro-Almagro, J. Bell, Chris Boultwood, R. Collins, Megan C. Conroy, N. Crabtree, N. Doherty, Alejandro F Frangi, N. Harvey, P. Leeson, K. Miller, S. Neubauer, Steffen Erhard Petersen, J. Sellors, Simon Sheard, Stephen M. Smith, C. Sudlow, P. Matthews, N. Allen   +23 more
semanticscholar   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source