Results 31 to 40 of about 220,549 (336)
American Journal of Epidemiology, 2017 The UK Biobank cohort is a population-based cohort of 500,000 participants recruited in the United Kingdom (UK) between 2006 and 2010. Approximately 9.2 million individuals aged 40–69 years who lived within 25 miles (40 km) of one of 22 assessment ...
A. Fry +7 more
semanticscholar +1 more source
Rare variant associations with plasma protein levels in the UK Biobank
Nature, 2023 Integrating human genomics and proteomics can help elucidate disease mechanisms, identify clinical biomarkers and discover drug targets^ 1 – 4 . Because previous proteogenomic studies have focused on common variation via genome-wide association studies ...
R. Dhindsa +100 more
semanticscholar +1 more source
The Geographical Distribution of Global Biobanks [PDF]
Cell JournalThis study aimed to comprehensively review the global biobanks to visualize their geographical distribution. The protocolfor this review consisted of the following steps: i.
Farzad Parvizpour +9 more
doaj +1 more source
Biobank quality management in the BBMRI.be network [PDF]
, 2019 From as early as 2005, different guidelines and quality standards covering biobank activities and sample handling methods have been developed to improve and guarantee the reproducibility of biomarker research.
Bekaert, Sofie +6 more
core +2 more sources
Genetics of 35 blood and urine biomarkers in the UK Biobank
Nature Genetics, 2020 Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n = 363,228 individuals).
Nasa Sinnott-Armstrong +19 more
semanticscholar +1 more source
Accurate Genomic Prediction Of Human Height [PDF]
, 2017 We construct genomic predictors for heritable and extremely complex human quantitative traits (height, heel bone density, and educational attainment) using modern methods in high dimensional statistics (i.e., machine learning).
Avery, Steven G. +5 more
core +1 more source
Frontiers in Medicine, 2020 The low reproducibility of biomarker research is a major holdback for the translation of research results to the bedside. Sample integrity has been identified as a key factor that contributes to improved reproducibility. The key mission of biobanks is to
Loes Linsen +2 more
doaj +1 more source
PRSice-2: Polygenic Risk Score software for biobank-scale data
GigaScience, 2019 Background Polygenic risk score (PRS) analyses have become an integral part of biomedical research, exploited to gain insights into shared aetiology among traits, to control for genomic profile in experimental studies, and to strengthen causal inference,
S. Choi, P. O’Reilly
semanticscholar +1 more source
A national registry for juvenile dermatomyositis and other paediatric idiopathic inflammatory myopathies: 10 years' experience; the Juvenile Dermatomyositis National (UK and Ireland) Cohort Biomarker Study and Repository for Idiopathic Inflammatory Myopathies [PDF]
, 2011 Objectives: The paediatric idiopathic inflammatory myopathies (IIMs) are a group of rare chronic inflammatory disorders of childhood, affecting muscle, skin and other organs.
Bohan +50 more
core +1 more source
Frontiers in Neurology, 2021 Background: The German research networks DescribePSP and ProPSP prospectively collect comprehensive clinical data, imaging data and biomaterials of patients with a clinical diagnosis of progressive supranuclear palsy.
Gesine Respondek +3 more
doaj +1 more source