Results 71 to 80 of about 26,930 (292)

Quantitative profiling of bacterial communities via full length 16S rRNA gene sequencing with internal controls: optimization and validation across diverse human microbiomes

BMC Microbiology
Background Accurate estimation of the microbial load is crucial for diagnosing infections and guiding treatment decisions. While traditional culture methods are informative, they are limited by their inability to grow all organisms.
Ezra Valido, Alessandro Bertolo, Jivko Stoyanov   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

New challenges in the biomedical science: biobanking problems and solutions

Acta Medica Lituanica, 2014
Background. A huge progress has been recently made in the field of biomedical research and personalized medicine. Despite the advances of biobanking, significant limitations remain that are restricting the impact of researches.
Živilė Gudlevičienė, Genovefa Chvatovič   +1 more
doaj   +1 more source

Biobanks in Europe: Prospects for Harmonisation and Networking [PDF]

, 2010
Biobanks (i.e. the organised collections consisting of biological samples and associated data, have gained great significance for research and personalised medicine) are increasingly recognised as a crucial infrastructure for research.
A. SCERRI Christian, BRAUN Anette, DESCHÊNES Mylène, FORTIER Isabel, IBARRETA RUIZ Dolores, LAAGE-HELLMAN Jens, PACI Daniele, RIJKERS-DEFRASNE Sylvie, SCHULTE IN DEN BÄUMEN Tobias, ZIKA Eleni   +9 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Introducing research initiatives into healthcare: What do doctors think? [PDF]

, 2014
Background: Current national and international policies emphasize the need to develop research initiatives within our health care system. Institutional biobanking represents a modern, large-scale research initiative that is reliant upon the support of ...
Hawkins, Nicholas J., Long, Janet, Smith, Sian, Ward, Robyn L., Wyld, Lucy   +4 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

biobank.cy: the Biobank of Cyprus past, present and future

Scientific Reports
The Cyprus Biobank collects biosamples, medical and lifestyle information with the aim of reaching 16,500 Cypriots aged ≥ 18-years, by year 2027, as part of a multitasked EU funded project. Volunteers are both from the general population and from disease
Eleni M. Loizidou, Maria Kyratzi, Maria A. Tsiarli, Andrea C. Kakouri, Georgia Charalambidou, Stella Antoniou, Stylianos Pieri, Panagiota Veloudi, Michaela Th. Mayrhofer, Andrea Wutte, Lukasz Kozera, Jens Habermann, Heimo Muller, Kurt Zatloukal, Karine Sargsyan, Alexandros Michaelides, Maria Papaioannou, Christos Schizas, Apostolos Malatras, Gregory Papagregoriou, Constantinos Deltas   +20 more
doaj   +1 more source

Evolving perspectives on broad consent for genomics research and biobanking in Africa. Report of the Second H3Africa Ethics Consultation Meeting, 11 May 2015. [PDF]

, 2016
A report on the Second H3Africa Ethics Consultation Meeting, which was held in Livingstone, Zambia on 11 May 2015. The meeting demonstrated considerable evolution by African Research Ethics Committees on thinking about broad consent as a consent option ...
de Vries, J, Littler, K, Matimba, A, McCurdy, S, Ouwe Missi Oukem-Boyer, O, Seeley, J, Tindana, P   +6 more
core   +1 more source

Biobanking Education [PDF]

Biopreservation and Biobanking, 2020
Marcos, Castellanos-Uribe, Emmanualle, Gormally, Hongkang, Zhou, Elisabeth, Matzke, Peter, H Watson   +4 more
openaire   +2 more sources