Results 41 to 50 of about 23,670 (299)

Inter- and Intra-Biobank Networks: Classification of Biobanks [PDF]

Pathobiology, 2010
<i>Background:</i> Many biobanks have struggled to deliver on the high expectations and claims made for them because of insufficient samples, inadequate infrastructure, cost of establishing and maintaining a large enough resource over the long term, and satisfying legal, ethics and governance requirements. Increasingly, networks have formed
Darren, Shickle, Marcus, Griffin, Karen, El-Arifi   +2 more
openaire   +2 more sources

The Geographical Distribution of Global Biobanks [PDF]

Cell Journal
This study aimed to comprehensively review the global biobanks to visualize their geographical distribution. The protocolfor this review consisted of the following steps: i.
Farzad Parvizpour, Sarvenaz Salahi, Mohammad Amin Mahmanzar, Karim Rahimian, Neda Esfandiari, Zahra Fatahi, Niousha Khoshdast, Reyhaneh Yarmohammadi, Mohamad Amir Amirkhani, Arefeh Jafarian   +9 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Integrating population-based biobanks: Catalyst for advances in precision health

Computational and Structural Biotechnology Journal
Precision health extends beyond the scope of precision medicine and involves a broader range of activities, including the prediction, prevention, treatment, and management of diseases.
Jui-Chu Lin, Yi-Lien Liu, Wesley Wei-Wen Hsiao, Chien-Te Fan   +3 more
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

“Adiós sui generis” : A Study of the legal Feasibility of the Sui Generis Right in the Context of Research Biobanks [PDF]

, 2013
The European protection of databases has been criticized for having a negative impact on the scientific development and the process of discovery. In the paper it is checked whether one of the most important research infrastructures, such as biobanks ...
Ducato, R., Ducato, Rossana
core  

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Clinical trials and the importance of biobanks in rare diseases [PDF]

Scripta Medica, 2018
Rare diseases ('orphan diseases') (RDs) count for 5000-8000 diseases with low prevalence and most commonly of genetic origin. Although most of rare diseases are manifested in early childhood, many are diagnosed in adults, even in elderly.
Nežić Lana, Vujić-Aleksić Vesna, Dukić Marina, Đeri Aleksandra   +3 more
doaj  

From pharmacogenetics to pharmaco-omics: Milestones and future directions

HGG Advances, 2022
The origins of pharmacogenetics date back to the 1950s, when it was established that inter-individual differences in drug response are partially determined by genetic factors.
Chiara Auwerx, Marie C. Sadler, Alexandre Reymond, Zoltán Kutalik   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source