Results 51 to 60 of about 20,995 (307)

The Public’s Awareness of and Attitude Toward Research Biobanks – A Regional German Survey

Frontiers in Genetics, 2018
Background: Biobanks have become an increasingly important means of biomedical research and innovation. However, they entail a variety of ethical, social and legal challenges, which need to be publicly discussed and managed collectively.
Sabine Bossert, Hannes Kahrass, Daniel Strech   +2 more
doaj   +1 more source

The UCLA ATLAS Community Health Initiative: Promoting precision health research in a diverse biobank

Cell Genomics, 2023
Summary: The UCLA ATLAS Community Health Initiative (ATLAS) has an initial target to recruit 150,000 participants from across the UCLA Health system with the goal of creating a genomic database to accelerate precision medicine efforts in California. This
Ruth Johnson, Yi Ding, Arjun Bhattacharya, Sergey Knyazev, Alec Chiu, Clara Lajonchere, Daniel H. Geschwind, Bogdan Pasaniuc   +7 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Lung cancer organoids: models for preclinical research and precision medicine

Frontiers in Oncology, 2023
Lung cancer is a malignancy with high incidence and mortality rates globally, and it has a 5-year survival rate of only 10%–20%. The significant heterogeneity in clinical presentation, histological features, multi-omics findings, and drug sensitivity ...
Yajing Liu, Yajing Liu, Yanbing Zhou, Pu Chen, Pu Chen   +4 more
doaj   +1 more source

Biobank@VITO: Biobanking the General Population in Flanders

Frontiers in Medicine, 2020
During the last 15 years, VITO has established an infrastructure for biobanking a collection of biological samples from the general population in Flanders (Belgium). This biobank was set up to contribute to future, yet unspecified, research questions in the field of environment and health.
Rosette Van Den Heuvel, Elly Den Hond, Ann Colles, Vera Nelen, Karen Van Campenhout, Greet Schoeters   +5 more
openaire   +3 more sources

Observational study on variability between biobanks in the estimation of DNA concentration

, 2009
There is little confidence in the consistency of estimation of DNA concentrations when samples move between laboratories. Evidence on this consistency is largely anecdotal.
Illig, T, Patton S, Wichmann H Erich, Päivi Laiho, Ring SM, Wichmann HE, Laiho, Päivi, Ollier WE, Foedinger, Manuela, Schmitz G, Bracegirdle, P, Krinka Dagni, Dixon, Katherine P, Krinka D, Ke X, Hardy, Matthew, Yuille MA, Donev Alexander N, Brown Jay, Hardy, M, Yuille, MA, Ring, SM, Donev, A.N., Donev, AN, Helen Stevens, Yuille, Martin A, Aslanidis C, Aslanidis Charalampos, Charalampos Aslanidis, Wichmann, H.-E., Bracegirdle P, Illig, T., Jay Brown, Alexander N Donev, Patton, S, Lagerberg, Camilla, Ke Xiayi, Illig Thomas, Laiho, P, McArdle Wendy, Xiayi Ke, Lagerberg, C, Laiho P, Schmitz Gerd, Schmitz, G., H Erich Wichmann, Gwilliam, R., Ring, S.M., Stevens, H., Gerd Schmitz, Brown, J, Wichmann, H Erich, Ring Susan M, Gwilliam Rhian, David H Lewis, Lewis DH, Krinka, D, Rhian Gwilliam, Ollier, William Er, Aslanidis, C, Patton, S., Ke, X., Gwilliam, Rhian, Brown, J., Foedinger M, Aslanidis, C., Lewis, DH, Pippa Bracegirdle, Susan M Ring, Laiho Päivi, Krinka, D., Dixon Katherine P, Dixon, KP, Yuille Martin A, Manuela Foedinger, Bracegirdle Pippa, Foedinger, M, Patton, Simon, Schmitz, G, Foedinger Manuela, Tybring G, Dagni Krinka, Aslanidis, Charalampos, Lewis, D.H., Ollier, WE, Martin A Yuille, Simon Patton, Stevens Helen, Stevens, Helen, McArdle, W., Bracegirdle, P., Schmitz, Gerd, Hardy Matthew, Dixon, K.P., Matthew Hardy, Ollier William ER, Wendy McArdle, Ollier, W.E., Lagerberg C, Gwilliam R, Donev AN, McArdle, W, Lewis David H, Tybring Gunnel, Bracegirdle, Pippa, Wichmann, H. Erich, Tybring, G, Tybring, Gunnel, Dixon, Katherine P., Donev, Alexander N., Gwilliam, R, Hardy, M., Donev, Alexander N, Yuille, Martin A.; id_orcid, Camilla Lagerberg, Patton Simon, Hardy M, Wichmann, HE, Ring, Susan M., Ke, Xiayi, McArdle, Wendy, Stevens H, Yuille, M.A., Illig T, Illig, Thomas, Lewis, David H, Krinka, Dagni, Katherine P Dixon, Foedinger, M., Thomas Illig, Tybring, G., Lagerberg Camilla, Ring, Susan M, Ollier, William E R, Dixon KP, William ER Ollier, Ke, X, Lagerberg, C., Laiho, P., McArdle W, Brown J, Stevens, H, Brown, Jay, Lewis, David H., Gunnel Tybring   +144 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Framework for setting up and operating biobanks.

, 2009
With regard to the use of bio materials, there is a great need for clarification of the legal ramifications. And since procuring and storing bio materials is becoming an increasingly important point for answering molecular-genetic questions within ...
Robienski, Jürgen, Simon, Jürgen
core   +1 more source