Results 71 to 80 of about 23,670 (299)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

BIOBANKS: GOVERNANCE IN COMPARATIVE PERSPECTIVE

, 2008
List of contributors -- Acknowledgements -- List of abbreviations -- Pt. 1. Conceptualizing biobanks -- 1. Biobanks and governance: an introduction / Herbert Gottweis and Alan Petersen -- 2.

core  

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Role of biobanks in the study of population immunity

Журнал инфектологии, 2018
Review focuses on estimation of population immunity and  effectiveness of vaccination against socially significant influenza  infection. Long-term observations of the population immunity,  including post-vaccine seroprevalence to influenza are an ...
O. S. Konshina, M. Yu. Eropkin, I. Yu. Nikonorov, M. G. Pozdnyakova   +3 more
doaj   +1 more source

ETHICAL ISSUES IN GOVERNING BIOBANKS: GLOBAL PERSPECTIVES

, 2008
Notes on the contributors -- Acknowledgements -- 1. Introduction: biobanks, genomics, and research a nightmare for public policy makers? / Alex Mauron -- Pt. 1. Research biobanks: current status and debates -- 2.

core  

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Inalienably Yours? The new case for an inalienable property right in human biological material: Empowerment of sample donors or a recipe for a tragic Anti-Commons?

SCRIPTed: A Journal of Law, Technology & Society, 2004
Modern biomedical research into the genetic component of common diseases calls for broad access to existing and novel collections of samples of human biological material, aka Biobanks.
Jasper A. Bovenberg
doaj  

CYP2D6 Metabolizer Status and Mortality in Metoprolol Users

Clinical and Translational Science
Numerous pharmacogenomic (PGx) associations of pharmacokinetics and pharmacodynamics of commonly prescribed medications have been reported. Yet, the evidence supporting their association on survival remains underexamined.
Simon deDenus, Essaïd Oussaïd, Maxime Meloche, Antoine‐Xavier Bertrand, Grégoire Leclair, Marie‐Christyne Cyr, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean‐Claude Tardif, Marie‐Pierre Dubé   +11 more
doaj   +1 more source

Exosomal delivery of CRISPR/Cas9 complexes for targeted editing of KRAS^G12D in pancreatic cancer: prerequisites for clinical surgical application

Український журнал клінічної хірургії
Objective. To evaluate exosomes obtained from patients with ductal adenocarcinoma of the pancreas as carriers of CRISPR/Cas9 complexes for targeted editing of KRAS^G12D in pancreatic cancer and to test their stability, editing efficiency, and ...
S. M. Gramatyuk, Yu. V. Ivanova, I. M. Mamontov, I. A. Kryvoruchko, E. Hubbard, K. Sargsyan   +5 more
doaj   +1 more source