Results 61 to 70 of about 20,995 (307)

Biobank networking and globalisation: perspectives and practices of Australian biobanks

Australian Health Review, 2020
Objective This study examined the practices and attitudes of Australian biobanks regarding access to samples and data, as well as local and global networking with other biobanks. Methods This was a mixed-methods study, including an ...
Edwina Light, Miriam Wiersma, Lisa Dive, Ian Kerridge, Wendy Lipworth, Cameron Stewart, Emma Kowal, Paula Marlton, Christine Critchley   +8 more
openaire   +6 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Rethinking scale in AI-driven genomic medicine – The role of small biobanks

Frontiers in Genetics
Artificial intelligence is rapidly advancing genomic medicine, but its clinical trustworthiness cannot be secured by larger datasets alone. This perspective argues that small biobanks, including national, regional, hospital-linked and disease-focused ...
Laura Grech, Laura Grech, Nikolai Paul Pace, Nikolai Paul Pace   +3 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Evolutionary concepts in biobanking - the BC BioLibrary

Journal of Translational Medicine, 2009
Background Medical research to improve health care faces a major problem in the relatively limited availability of adequately annotated and collected biospecimens.
Hegele Richard G, Png Adrian, Giesz Sara C, Barnes Rebecca O, Wilson-McManus Janet E, Watson Peter H, Brinkman Jacquelyn N, Mackenzie Ian R, Huntsman David G, Junker Anne, Gilks Blake, Skarsgard Erik, Burgess Michael, Aparicio Samuel, McManus Bruce M   +14 more
doaj   +1 more source

Respondents’ main role related to biobanks and types of biobanks.

, 2019
Respondents’ main role related to biobanks and types of biobanks.
Martin Boeckhout (7400720), Lars Ursin (7400708), Liis Leitsalu (3686728), Gillian Martin (6451223), Anna Durnová (7400711), Marialuisa Lavitrano (485800), Sara Casati (7400717), Michaela Th. Mayrhofer (7400723), Melanie Goisauf (7400699), Deborah Mascalzoni (76505), Isabelle Budin-Ljøsne (7400705), Heidi Beate Bentzen (7400702), Katharine Smith (7400714)   +12 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Role of biobanks in the study of population immunity

Журнал инфектологии, 2018
Review focuses on estimation of population immunity and  effectiveness of vaccination against socially significant influenza  infection. Long-term observations of the population immunity,  including post-vaccine seroprevalence to influenza are an ...
O. S. Konshina, M. Yu. Eropkin, I. Yu. Nikonorov, M. G. Pozdnyakova   +3 more
doaj   +1 more source