Results 81 to 90 of about 31,338 (290)

Visions and Challenges in Managing and Preserving Data to Measure Quality of Life

, 2018
Health-related data analysis plays an important role in self-knowledge, disease prevention, diagnosis, and quality of life assessment. With the advent of data-driven solutions, a myriad of apps and Internet of Things (IoT) devices (wearables, home ...
Estrada-Galinanes, Vero, Wac, Katarzyna
core   +1 more source

A comparative analysis of the requirements for the use of data in biobanks based in Finland, Germany, the Netherlands, Norway and the United Kingdom [PDF]

, 2014
To understand the causes of disease and improve diagnosis and treatment regimes, biomedical researchers need access to large numbers of well-characterized data and samples. Over the past decade, biobanks have been established across Europe to collect and
Hoppe, Nils, Kaye, Jane, Knoppers, Bartha M., Mitchell, Colin, Moraia, Lindaa Briceno, Soini, Sirpa, Tasse, Anne Marie, Wallace, Susan E., Øien, Morten   +8 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Penser le corps-marchandise avec Alfred Sohn-Rethel

Recherches Germaniques, 2020
This article analyzes the commodification of the human body with the help of Alfred Sohn-Rethel’s work, which clarifies two distinct processes. On the one hand, it shows that monetization is only possible by reducing reality to a quantity.
Fabrice Colomb
doaj   +1 more source

Applying metabolomics to cardiometabolic intervention studies and trials: past experiences and a roadmap for the future [PDF]

, 2016
Metabolomics and lipidomics are emerging methods for detailed phenotyping of small molecules in samples. It is hoped that such data will: (i) enhance baseline prediction of patient response to pharmacotherapies (beneficial or adverse); (ii) reveal ...
Preiss, David, Rankin, Naomi J., Sattar, Naveed, Welsh, Paul   +3 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Exosomal delivery of CRISPR/Cas9 complexes for targeted editing of KRAS^G12D in pancreatic cancer: prerequisites for clinical surgical application

Український журнал клінічної хірургії
Objective. To evaluate exosomes obtained from patients with ductal adenocarcinoma of the pancreas as carriers of CRISPR/Cas9 complexes for targeted editing of KRAS^G12D in pancreatic cancer and to test their stability, editing efficiency, and ...
S. M. Gramatyuk, Yu. V. Ivanova, I. M. Mamontov, I. A. Kryvoruchko, E. Hubbard, K. Sargsyan   +5 more
doaj   +1 more source

La marchandisation du corps à l’épreuve des biobanques

La Nouvelle Revue du Travail, 2019
The article views biobanking in France as one way of apprehending the commodification of the human body. It applies a Marxist understanding of commodities to analyse what happens to biological samples once they have been treated by biobanks.
Fabrice Colomb
doaj   +1 more source

The lady vanishes: what's missing from the stem cell debate [PDF]

, 2006
Most opponents of somatic cell nuclear transfer and embryonic stem cell technologies base their arguments on the twin assertions that the embryo is either a human being or a potential human being, and that it is wrong to destroy a human being or ...
A. Fagot-Largeault, A. Jacobs, A. M. Honore, A. Ryan, C. A. MacKinnon, C. McLeod, C. Pateman, C. Waldby, CCNE (Comite Consultatif National d’Ethique), CCNE (Comite Consultatif National d’Ethique) and Nationaler Ethikrat. Opinion no. 77, D. B. Resnik, D. Dickenson, D. Dickenson, D. Dickenson, D. Dickenson, D. Dickenson, D. Dickenson, D. Dickenson, Donna L. Dickenson, E. Marshall, G. A. Cohen, G. Meilander, G. W. F. Hegel, HUGO (Human Genome Organisation) Ethics Council, I. Schneider, J. Boyle, J. E. Penner, J. E. Penner, J. L. Schroeder, J. Locke, J. Mahoney, J. McHale, J. Montgomery, J. W. Harris, J. Waldron, K. E. Ferguson, K. Momberger, L. Brace, M. J. Radin, R. Macklin, R. R Faden, Royal College of Obstetricians and Gynaecologists (RCOG) Ethics Committee, S. Dodds, S. E. Lanzendorf, S. Holland, S. Holm, T. Grey, T. Harrison, T. Murray, W. E. Connolly, W. S. Hwang   +50 more
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source