Results 141 to 150 of about 47,461 (243)

Harnessing Non‐Covalent Protein–Protein Interaction Domains for Production of Biocatalytic Materials Systems

Advanced Functional Materials, Volume 36, Issue 11, 5 February 2026.
Non‐covalent protein–protein interactions mediated by SH3, PDZ, or GBD domains enable the self‐assembly of stable and biocatalytically active hydrogel materials. These soft materials can be processed into monodisperse foams that, once dried, exhibit enhanced mechanical stability and activity and are easily integrated into microstructured flow ...
Julian S. Hertel, Maria Alessandra Martini, Marius Stoeckle, Annika J. Weber, Kersten S. Rabe, Christof M. Niemeyer   +5 more
wiley   +1 more source

LDI, A Lipid Droplet Inhibitor, Disrupts Lipid Accumulation and Modulates Hepatic Lipid Profiles in Fatty Liver

Advanced Materials, Volume 38, Issue 7, 2 February 2026.
The lipid droplet inhibitor (LDI), templated with large‐pore mesoporous silica and functionalized with PKCα C1A and lipase, targets lipid degradation in fatty liver. The LDI maintains stable association with lipid droplets, thereby suppressing their formation and expansion.
Seunghee Kim, Yeojin Kim, Sanjita Paudel, In Young Kang, Suyeon Kim, Jeesoo Kim, Sunmi Park, Seung‐Hoi Koo, Hyun Sung Kim, Dae Won Jun, Jinyoung Park, Hyunbeom Lee, Joonseok Lee   +12 more
wiley   +1 more source

Phase Engineering of Nanogold: Non‐Close Packed Square Planes in A′B′ Stacking with a 0.5 Å Channel

Advanced Materials, Volume 38, Issue 8, 6 February 2026.
Gold is well known to adopt the face‐centered‐cubic (fcc) structure. This work presents an unusual non‐close‐packed phase attained in a 40‐atom gold nanocluster, which is in contrast with the close‐packed fcc quasi‐isomer. The non‐compact structure exhibits exclusive square planes in a layer‐by‐layer stacking, hence, possessing a unique 0.5 Å channel ...
Yitong Wang, Zhongyu Liu, Christopher G. Gianopoulos, Wei Zhang, Dominic Alfonso, Guiying He, Kristin Kirschbaum, Meng Zhou, Rongchao Jin   +8 more
wiley   +1 more source

Structure of the imine reductase from Ajellomyces dermatitidis in three crystal forms. Corrigendum. [PDF]

Acta Crystallogr F Struct Biol Commun
Sharma M, Cuetos A, Williams A, González-Martínez D, Grogan G.   +4 more
europepmc   +1 more source

Biocatalytic Asymmetric Michael Addition of Thiols to α,β‐Unsaturated Aldehydes via Enzyme‐Bound Iminium Ion Intermediates

Advanced Synthesis &Catalysis, Volume 368, Issue 3, 3 February 2026.
Biocatalytic stereo‐controlled C–S bond formation unlocked! Engineered, cofactor‐independent 4‐oxalocrotonate tautomerase variants catalyze enantioselective thia‐Michael additions of aliphatic thiols to cinnamaldehyde, affording (R)‐β‐thioenals with up to 99% conversion and high enantiopurity (up to 95:5 e.r.).
Michele Crotti, Pieter G. Tepper, Thim de Jong, Gerrit J. Poelarends   +3 more
wiley   +1 more source

Diazirines Beyond Photoaffinity Labeling: A Comprehensive Overview of Applications in Biological Sciences, Materials Chemistry, and NMR‐Spectroscopy

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
Diazirines are three‐membered, nitrogen‐containing heterocycles that decompose under light or heat to generate carbenes. For the past two decades, they have served mainly as minimally invasive tags in photoaffinity labeling (PAL). More recently, their value as versatile carbene precursors has been recognized.
Dominik Schnalzer, Viktor Savic, Clemens Cziegler, Michael Schnürch, Marko D. Mihovilovic   +4 more
wiley   +2 more sources

Complex Coacervate Emulsions as a Strategy to Stabilize Enzymes for Catalysis in Organic Solvents. [PDF]

ACS Macro Lett
Penido JA, Le SP, Varadarajan A, Thayumanavan S, Perry SL, Loh W.   +5 more
europepmc   +1 more source

First‐Principles Structure–Activity Relationship Insights Into Phenolic Scaffolds: QSAR Modeling and Drug‐Likeness Screening

Advanced Theory and Simulations, Volume 9, Issue 2, February 2026.
Integrated machine learning framework for phenolic derivatives: classification (toxicity) and regression (logP) models identify top drug‐like compounds. Random Forest outperformed for toxicity, while Linear Regression best predicted logP. A weighted scoring approach prioritized five safe, lipophilicity‐optimized candidates, supporting rational ...
Houria Nacer, Sridhar Priyankha, Gopal Hema, Anouar Zerouali, Hamza Haddag, Muneerah Mogren Al Mogren, Muthuramalingam Prakash, Majdi Hochlaf   +7 more
wiley   +1 more source

Advances and Challenges in Bioprocess Optimization for the Synthesis of Sugar Nucleotides. [PDF]

Chembiochem
Roberts TL, Cosgrove SC, Miller GJ.
europepmc   +1 more source

Surface Engineered Biomolecular Condensates for Targeted Cell Cytotoxicity

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Interfacial engineering of biomolecular condensates with a decanoic acid (DA) membrane enables molecular‐weight‐gated enzyme localization. Small biomolecules (≤60 kDa) enrich internally, while high‐molecular‐weight alkaline phosphatase (ALP) localizes at the interface.
Chengying Yin, Cheng Wu, Xinran Yu, Yifeng Zhu, Baohu Wu, Yue Wang, Liangfei Tian   +6 more
wiley   +1 more source