Results 141 to 150 of about 47,665 (229)

A Guide to Bayesian Optimization in Bioprocess Engineering

Biotechnology and Bioengineering, Volume 123, Issue 4, Page 805-830, April 2026.
ABSTRACT Bayesian optimization has become widely popular across various experimental sciences due to its favorable attributes: it can handle noisy data, perform well with relatively small data sets, and provide adaptive suggestions for sequential experimentation.
Maximilian Siska, Emma Pajak, Katrin Rosenthal, Antonio del Rio Chanona, Eric von Lieres, Laura M. Helleckes   +5 more
wiley   +1 more source

Structure of the imine reductase from Ajellomyces dermatitidis in three crystal forms. Corrigendum. [PDF]

Acta Crystallogr F Struct Biol Commun
Sharma M, Cuetos A, Williams A, González-Martínez D, Grogan G.   +4 more
europepmc   +1 more source

Extracellular and Membrane Protein: Structure, Biological Functions, Diseases, and an Emerging Modality for Drug Discovery

MedComm, Volume 7, Issue 4, April 2026.
Targeted protein degradation represents a paradigm shift from traditional protein inhibition to complete protein elimination. This is achieved through three main strategies for degrading extracellular and membrane proteins: recruitment of cell‐surface LTRs, engagement of intracellular proteins, and receptor‐independent mechanisms.
Mengqing Zhao, Wenhao Yin, Jianjian Han, Huimin Wang, Zheng Liu, Lilong Liu, Wuxiang Mao   +6 more
wiley   +1 more source

Advances and Challenges in Bioprocess Optimization for the Synthesis of Sugar Nucleotides. [PDF]

Chembiochem
Roberts TL, Cosgrove SC, Miller GJ.
europepmc   +1 more source

DNAzyme‐Based Nanostructures for Dynamic Cell Regulation and Sensing

ChemistryOpen, Volume 15, Issue 4, April 2026.
This review explores DNAzyme‐based nanostructures for dynamic cell regulation and sensing. By merging catalytic DNA with nanomaterials, they enable precise metal‐ion detection, programmable cell–cell interactions, and high‐resolution bioimaging. These advances open new routes to smart theranostic platforms and clinical translation in precision medicine.
Haoyu Fan, Xichen Du, Ruocan Qian
wiley   +1 more source

Complex Coacervate Emulsions as a Strategy to Stabilize Enzymes for Catalysis in Organic Solvents. [PDF]

ACS Macro Lett
Penido JA, Le SP, Varadarajan A, Thayumanavan S, Perry SL, Loh W.   +5 more
europepmc   +1 more source

Structural and evolutionary dissection of NADPH‐binding motifs in NADPH‐preferring ene‐reductases

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Ene‐reductases (ERs) catalyze nicotinamide‐dependent, stereoselective reductions of activated CC bonds. While their catalytic chemistry and applications are well‐explored, cosubstrate (NAD(P)H) binding remains poorly understood. Most ERs strongly prefer NADPH despite lacking canonical dinucleotide‐binding folds and instead employ flexible ...
Bianca Kerschbaumer, Eva M. Frießer, Silvia Wallner, Gustav Oberdorfer, Michael Friess, Rolf Breinbauer, Peter Macheroux, Aleksandar Bijelic   +7 more
wiley   +1 more source

Creation of a fungal production platform for biosurfactants by P450 engineering [PDF]

, 2015
De Vos, Gwen, Geys, Robin, Lemmens, Christophe, Soetaert, Wim, Van Bogaert, Inge   +4 more
core  

StabLyzeGraph: High‐throughput screening of combinatorial mutations using graph neural networks

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Engineering protein stability is a powerful strategy across biotechnology and medicine, supporting a broad range of applications such as atomic structure determination, discovery of therapeutic molecules, biomanufacturing, diagnostic reagents, industrial biocatalysis, etc.
Muhammad Waqas, Benito Natale, Michele Roggia, Prasenjit Prasad Saha, Mauro Mileni, Sandro Cosconati   +5 more
wiley   +1 more source

Advancing Biocatalysis Education: Sustaining the Future of Industrial Biotechnology. [PDF]

JACS Au
Weise NJ, France SP.
europepmc   +1 more source