Results 31 to 40 of about 225,988 (282)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Glucose limited feed strategy leads to increased production of fusicocca-2,10(14)-diene by Saccharomyces cerevisiae

AMB Express, 2018
Fusicocca-2,10(14)-diene (FCdiene) is a diterpene which is interesting as a precursor of the anti-cancer drug fusicoccin A and therefore for pharmaceutical applications. Production of FCdiene using a genetically modified Saccharomyces cerevisiae has been
Lisa Marie Halka, Christian Nowacki, Alica Kleinschmidt, Kevin Koenen, Rolf Wichmann   +4 more
doaj   +1 more source

Application of the Zimm-Bragg Model to the Removal of Azo Dyes with Pectin

Adsorption Science & Technology, 2021
In this work, the ability of pectin (Pec) to remove direct red 80 (DR80), Congo red (CR), methyl orange (MO), and methyl red (MR) was studied. The removal percentages under adequate pH and ionic strength conditions were as follows: DR80 (99.5%), CR (99.8%
Juan Antonio Lozano-Álvarez, Juan Jáuregui-Rincón, Iliana E. Medina-Ramírez, Rogelio Salinas-Gutiérrez, Jorge Martín Alférez Chávez, Guadalupe Javier Araiza-Arvilla   +5 more
doaj   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Routes to industrial scalability to maximise investment in engineering biology in the UK—A bioplastics small and medium‐sized enterprise perspective

Engineering Biology
Focus on engineering biology is at the forefront of the UK government's objectives, being one of their five critical technologies (the others being quantum technologies, artifical intelligence, semiconductors, and future telecommunications), with a ...
Amy Switzer, Laima Šusta, Paul Mines
doaj   +1 more source

Black glucose-releasing silicon elastomer rings for fed-batch operation allow measurement of the oxygen transfer rate from the top and optical signals from the bottom for each well of a microtiter plate

BMC Biotechnology, 2023
Background In industrial microbial biotechnology, fed-batch processes are frequently used to avoid undesirable biological phenomena, such as substrate inhibition or overflow metabolism.
Sarah Sparviero, Laura Barth, Timm Keil, Carl Dinter, Christoph Berg, Clemens Lattermann, Jochen Büchs   +6 more
doaj   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Shake flask methodology for assessing the influence of the maximum oxygen transfer capacity on 2,3-butanediol production

Microbial Cell Factories, 2019
Background Production of 2,3-butanediol from renewable resources is a promising measure to decrease the consumption of fossil resources in the chemical industry.
Benedikt Heyman, Robin Lamm, Hannah Tulke, Lars Regestein, Jochen Büchs   +4 more
doaj   +1 more source

Benchmarking biopharmaceutical process development and manufacturing cost contributions to R&D

mAbs, 2020
This study aims to benchmark and analyze the process development and manufacturing costs across the biopharmaceutical drug development cycle and their contribution to overall research and development (R&D) costs.
Suzanne S. Farid, Max Baron, Christos Stamatis, Wenhao Nie, Jon Coffman   +4 more
doaj   +1 more source