Results 171 to 180 of about 1,010,901 (298)

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Magnetic Resonance Imaging-Based Artificial Intelligence in Predicting Prostate Cancer Biochemical Recurrence: Systematic Review and Meta-Analysis. [PDF]

J Med Internet Res
Jin Y, Yuan T, Chen Z.
europepmc   +1 more source

Biochemical Recurrence Irradiation or Observation (BRIO) in patients with prostate cancer: protocol for a randomised control trial. [PDF]

BJU Int
Wei N, Phillips RM, Kwon E, Stish BJ, Ehman EC, Lucien F, O'Byrne J, Bobek O, Shi Q, Andrews JR, Boorjian SA, Park SS, Orme JJ, Sharma V.   +13 more
europepmc   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Plasma Proteomic Profiling Was Used to Discover a Biochemical Recurrence Prediction Model for Prostate Cancer. [PDF]

Mol Cell Proteomics
Xu N, Zhang L, Yao Z, Li L, Cai M, Wang Y, Wang X, Tan S, Li K, Lyu J, Wang H, Qin Z, Feng J, Dai B, Zhu Y, Xiang H, Qin X, Lin G, Gu Y, Ding F, Zhao J, Qu Y, Ding C, Ye D, Yang W.   +24 more
europepmc   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Divergent effects of PLA2G7 on prostate cancer biochemical recurrence in European American and African American men. [PDF]

J Natl Cancer Inst
Paller CJ, Wei S, Schumacher M, Rabizadeh D, Hsu YC, Lu C, Chen Y, Jing Y, Trock BJ, Kanayama M, Ambs S, Stafforini DM, Isaacs WB, Netto GJ, Lotan TL, De Marzo AM, Platz EA, Luo J.   +17 more
europepmc   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Salvage Radiotherapy Confers an Overall Survival Advantage in Biochemical Recurrence of Prostate Cancer: Evidence from the International PROMISE Registry. [PDF]

J Nucl Med
Guberina N, Karpinski MJ, Guberina M, Hoberück S, Miederer M, Hölscher T, Rauscher I, Eiber M, Nguyen A, Theus L, Bauckneht M, Scholtissek H, Rahbar K, Miksch J, Pizzuto DA, Goffin K, Civan C, Reinwand SF, Stang A, Kleesiek J, Merkel-Jens A, Umutlu L, Santangelo A, Soeterik TFW, Beintner-Skawran S, Vondrak A, Bjartell A, Evangelista L, Rasul S, Miszczyk M, Holzgreve A, Sheikh GT, Di Giorgio A, Farolfi A, Herrmann K, Hadaschik B, Fendler WP, Stuschke M.   +37 more
europepmc   +1 more source