Results 71 to 80 of about 1,905,672 (358)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Understanding biochemical recurrence after radical prostatectomy: trust biology, not a number [PDF]

, 2023
Simone Albisinni, Romain Diamand
openalex   +1 more source

The Impact of Experience on the Risk of Surgical Margins and Biochemical Recurrence after Robot-Assisted Radical Prostatectomy: A Learning Curve Study.

Journal of Urology, 2019
PURPOSE Improved cancer control with increasing surgical experience (the learning curve) has been demonstrated for open and laparoscopic prostatectomy.
C. Bravi, A. Tin, E. Vertosick, E. Mazzone, A. Martini, P. Dell’Oglio, A. Stabile, G. Gandaglia, N. Fossati, N. Suardi, A. Gallina, A. Briganti, F. Montorsi, A. Vickers   +13 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Salvage conformal radiotherapy for biochemical recurrent prostate cancer after radical prostatectomy

International Brazilian Journal of Urology, 2006
OBJECTIVE: Assess the results of salvage conformal radiotherapy in patients with biochemical failure after radical prostatectomy and identify prognostic factors for biochemical recurrence and toxicity of the treatment.
Carlos R. Monti, Ricardo A. Nakamura, Robson Ferrigno, Aristides Rossi Jr, Neusa S. Kawakami, Felipe A. Trevisan   +5 more
doaj   +1 more source

Time without PSA recurrence after radical prostatectomy as a predictor of future biochemical recurrence, metastatic disease and prostate cancer death: a prospective Scandinavian cohort study

BMJ Open, 2022
Objective Although surveillance after radical prostatectomy routinely includes repeated prostate specific antigen (PSA)-testing for many years, biochemical recurrence often occurs without further clinical progression.
Mats Steinholtz Ahlberg, Hans-Olov Adami, Hans Garmo, Lars Holmberg, Anna Bill-Axelson, Ove Andren, Gunnar Steineck, Jan-Erik Johansson   +7 more
doaj   +1 more source

Supplementary Tables S1-S4 from Higher Expression of the Androgen-Regulated Gene <i>PSA/HK3</i> mRNA in Prostate Cancer Tissues Predicts Biochemical Recurrence-Free Survival [PDF]

, 2023
Joseph R. Sterbis, Chunling Gao, Bungo Furusato, Yongmei Chen, Syed Shaheduzzaman, Lakshmi Ravindranath, David Osborn, Inger L. Rosner, Albert Dobi, David G. McLeod, Isabell A. Sesterhenn, Shiv Srivastava, Jennifer Cullen, György Petrovics   +13 more
openalex   +1 more source

A qualitative transcriptional signature for predicting the biochemical recurrence risk of prostate cancer patients after radical prostatectomy

The Prostate, 2020
The qualitative transcriptional characteristics, the within‐sample relative expression orderings (REOs) of genes, are highly robust against batch effects and sample quality variations.
Xiang Li, Haiyan Huang, Jiahui Zhang, Fengle Jiang, Yating Guo, Yidan Shi, Zheng Guo, Lu Ao   +7 more
semanticscholar   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

A Prospective Study on 18F-DCFPyL PSMA PET/CT Imaging in Biochemical Recurrence of Prostate Cancer

Journal of Nuclear Medicine, 2019
18F-DCFPyL (2-(3-{1-carboxy-5-[(6-18F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid), a prostate-specific membrane antigen–targeting radiotracer, has shown promise as a prostate cancer imaging radiotracer.
Étienne Rousseau, Donald A. Wilson, F. Lacroix-Poisson, A. Krauze, K. Chi, M. Gleave, M. Mckenzie, S. Tyldesley, S. Goldenberg, F. Bénard   +9 more
semanticscholar   +1 more source