Results 91 to 100 of about 368,095 (294)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Mutations, Differential Gene Expression, and Chimeric Transcripts in Esophageal Squamous Cell Carcinoma Show High Heterogeneity

Translational Oncology, 2018
Esophageal squamous cell carcinoma (ESCC) is a frequent and lethal neoplasia. As recent advances in targeted therapy have not improved ESCC prognosis, characterization of molecular alterations associated to this tumor is of foremost relevance.
Paulo Thiago de Souza-Santos, Sheila Coelho Soares Lima, Pedro Nicolau-Neto, Mariana Boroni, Nathalia Meireles Da Costa, Lilian Brewer, Albert Nobre Menezes, Carolina Furtado, Miguel Angelo Martins Moreira, Hector N. Seuanez, Tatiana de Almeida Simão, Luis Felipe Ribeiro Pinto   +11 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

A European database of Fusarium graminearum and F. culmorum trichothecene genotypes

Frontiers in Microbiology, 2016
Fusarium species, particularly Fusarium graminearum and F. culmorum, are the main cause of trichothecene type B contamination in cereals. Data on the distribution of Fusarium trichothecene genotypes in cereals in Europe are scattered in time and space ...
Matias ePasquali, Marco eBeyer, Antonio eLogrieco, Kris eAudenaert, Virgilio eBalmas, Ryan eBasler, Anne-Laure eBoutigny, Jana eChrpová, Elżbieta eCzembor, Tatiana eGagkaeva, María Teresa eGonzález-Jaén, Ingerd Skow eHofgaard, Nagehan Desen eKöycü, Lucien eHoffmann, Jelena eLević, Patricia Marín eGarcía, Thomas eMiedaner, Quirico eMigheli, Antonio eMoretti, Marina Elsa Herta eMüller, Françoise eMunaut, Päivi eParikka, Marine ePallez-Barthel, Jonathan ePiec, Jonathan eScauflaire, Barbara eScherm, Slavica eStanković, Ulf eThrane, Silvio eUhlig, Adriaan eVanheule, Tapani eYli-Mattila, Susanne eVogelgsang   +31 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

High - and low-impact citation measures: empirical applications [PDF]

This paper contains the first empirical applications of a novel methodology for comparing the citation distributions of research units working in the same homogeneous field.
Ignacio Ortuño, Javier Ruiz-Castillo, Pedro Albarrán   +2 more
core   +3 more sources

Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment

Genome Medicine
Background Monocytes are recruited to tumors and undergo transcriptional reprogramming resulting in tumor-promoting functions. Epigenomic features, such as post-translational modification of histones and chromatin accessibility, are key determinants of ...
Máté Kiss, Laszlo Halasz, Eva Hadadi, Wilhelm K. Berger, Petros Tzerpos, Szilard Poliska, Daliya Kancheva, Aurélie Gabriel, Romina Mora Barthelmess, Ayla Debraekeleer, Jan Brughmans, Yvon Elkrim, Liesbet Martens, Yvan Saeys, Bence Daniel, Zsolt Czimmerer, Damya Laoui, Laszlo Nagy, Jo A. Van Ginderachter   +18 more
doaj   +1 more source