Results 91 to 100 of about 360,147 (291)

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Mutations, Differential Gene Expression, and Chimeric Transcripts in Esophageal Squamous Cell Carcinoma Show High Heterogeneity

Translational Oncology, 2018
Esophageal squamous cell carcinoma (ESCC) is a frequent and lethal neoplasia. As recent advances in targeted therapy have not improved ESCC prognosis, characterization of molecular alterations associated to this tumor is of foremost relevance.
Paulo Thiago de Souza-Santos, Sheila Coelho Soares Lima, Pedro Nicolau-Neto, Mariana Boroni, Nathalia Meireles Da Costa, Lilian Brewer, Albert Nobre Menezes, Carolina Furtado, Miguel Angelo Martins Moreira, Hector N. Seuanez, Tatiana de Almeida Simão, Luis Felipe Ribeiro Pinto   +11 more
doaj   +1 more source

Translational control 1995–2015: unveiling molecular underpinnings and roles in human biology

RNA: A publication of the RNA Society, 2015
The last 20 years have seen tremendous progress in deciphering the fundamental mechanisms of protein synthesis and molecular pathways of translational control, and in implicating these processes in development, neurobiology, and etiologyof human diseases.
A. Hinnebusch
semanticscholar   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

A European database of Fusarium graminearum and F. culmorum trichothecene genotypes

Frontiers in Microbiology, 2016
Fusarium species, particularly Fusarium graminearum and F. culmorum, are the main cause of trichothecene type B contamination in cereals. Data on the distribution of Fusarium trichothecene genotypes in cereals in Europe are scattered in time and space ...
Matias ePasquali, Marco eBeyer, Antonio eLogrieco, Kris eAudenaert, Virgilio eBalmas, Ryan eBasler, Anne-Laure eBoutigny, Jana eChrpová, Elżbieta eCzembor, Tatiana eGagkaeva, María Teresa eGonzález-Jaén, Ingerd Skow eHofgaard, Nagehan Desen eKöycü, Lucien eHoffmann, Jelena eLević, Patricia Marín eGarcía, Thomas eMiedaner, Quirico eMigheli, Antonio eMoretti, Marina Elsa Herta eMüller, Françoise eMunaut, Päivi eParikka, Marine ePallez-Barthel, Jonathan ePiec, Jonathan eScauflaire, Barbara eScherm, Slavica eStanković, Ulf eThrane, Silvio eUhlig, Adriaan eVanheule, Tapani eYli-Mattila, Susanne eVogelgsang   +31 more
doaj   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Sustainability and groundwater in the context of Water-Energy-Food Nexus: a review of the literature

Derbyana
The sustainability of groundwater is contingent upon the Water-Energy-Food Nexus. In this context, the article aimed to analyze the state of the art in this field by using the Scopus database and the following keywords: “Sustainability”, “Nexus”, and ...
Sandra Milena Vélez Echeverry, Adriana Marques, Sueli Yoshinaga Pereira   +2 more
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment

Genome Medicine
Background Monocytes are recruited to tumors and undergo transcriptional reprogramming resulting in tumor-promoting functions. Epigenomic features, such as post-translational modification of histones and chromatin accessibility, are key determinants of ...
Máté Kiss, Laszlo Halasz, Eva Hadadi, Wilhelm K. Berger, Petros Tzerpos, Szilard Poliska, Daliya Kancheva, Aurélie Gabriel, Romina Mora Barthelmess, Ayla Debraekeleer, Jan Brughmans, Yvon Elkrim, Liesbet Martens, Yvan Saeys, Bence Daniel, Zsolt Czimmerer, Damya Laoui, Laszlo Nagy, Jo A. Van Ginderachter   +18 more
doaj   +1 more source