Results 101 to 110 of about 133,000 (268)

Translational research methods: Basics of renal molecular biology

, 2015
Molecular biology has developed between years 1940s and 1960s as a branch of science that spans from genetics to cell biology and biochemistry with the goal of understanding the interactions by which DNA, RNA, and protein synthesis operate into cells [1].
Bruschi M., Sanna-Cherchi S., Ghiggeri G. M.   +2 more
core   +1 more source

Targeting ubiquitin-specific protease 14 reduces metastatic potential and metabolic activity in cervical cancer via direct modulation of monocarboxylate transporter-4

Journal of Translational Medicine
Background Cervical cancer (CC) remains a major health burden in low- and middle-income countries, where HPV vaccination coverage is suboptimal. Ubiquitin-specific peptidase 14 (USP14), a proteasome-associated deubiquitinase, has emerged as a potential ...
Ravi Chauhan, Gunjan Dagar, Lakshay Malhotra, Ashna Gupta, Anju Surendranath, Harshul Kapoor, Hemant Yadav, Rajat Ujjainiya, Suraja Kumar Das, Sameer Mirza, Mukesh Tanwar, Pranay Tanwar, Abdul S. Ethayathulla, Archana Singh, Muzafar A. Macha, Shahab Uddin, Ammira S. Al-Shabeeb Akil, Sandeep Mathur, Tej K. Pandita, Ajaz A. Bhat, Mayank Singh   +20 more
doaj   +1 more source

Economic Evaluation of Multiple-Pharmacogenes Testing for the Prevention of Adverse Drug Reactions in People Living with HIV

ClinicoEconomics and Outcomes Research, 2022
Saowalak Turongkaravee,1 Naiyana Praditsitthikorn,2 Thundon Ngamprasertchai,3 Jiraphun Jittikoon,4 Surakameth Mahasirimongkol,5 Chonlaphat Sukasem,6– 9 Wanvisa Udomsinprasert,4 Olivia Wu,10 Usa Chaikledkaew11,12 1Social, Economic and Administrative ...
Turongkaravee S, Praditsitthikorn N, Ngamprasertchai T, Jittikoon J, Mahasirimongkol S, Sukasem C, Udomsinprasert W, Wu O, Chaikledkaew U   +8 more
doaj  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Dispersal and genetic variability of Sonchus oleraceus L. in relation to its resistance to ALS-inhibiting herbicides.

, 2011
The work described in this thesis investigates the existence and level of acetolactate synthase (ALS)-inhibiting herbicide resistance in Sonchus oleraceus in Australia. It further discusses the sensitivity of different S.
St. John-Sweeting, Robin S.
core  

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Population genetics of bottlenose dolphins (Tursiops truncatus) from an Anglo-Saxon archaeological site in comparison with modern populations. [PDF]

, 2004
Bottlenose dolphins {Tursiops truncatus) exhibit a cosmopolitan distribution, being found in temperate and tropical oceans throughout the world. Members of this species in the waters surrounding Britain are the most northerly populations and show a ...
Nichols, Courtney Dawn
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Studies in neuraminidases [PDF]

In this thesis, the work undertaken in an attempt to gain insight into the catalytic function of neuraminidase is described. The history, properties and importance of neuraminidases are reviewed in Chapter One.
Kabayo, John P.
core