Results 81 to 90 of about 352,777 (258)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Bibliometric analysis of publication trends on ocular hygiene and infections in the past two decades

GMS Hygiene and Infection Control
Background: Ocular hygiene encompasses a spectrum of measures to initiate and maintain adequate ocular cleanliness to prevent eye infections and their further transmission.
Ali, Mohsan, Naseer, Bisal, Insaf Ahmed, Rawal Alias, Talha, Muhammad, Saqib, Moeez, Anwar, Amar   +5 more
doaj   +1 more source

The Algorithmic Origins of Life [PDF]

, 2012
Although it has been notoriously difficult to pin down precisely what it is that makes life so distinctive and remarkable, there is general agreement that its informational aspect is one key property, perhaps the key property.
Cairns-Smith AG, Campbell DT, Cline DB, Davies PCW, Davies PCW, Ellis GFR, Gesteland RF, Hofstadter D, Kauffman S, Kolmogorov AN, Küppers BO, Paul C. W. Davies, Pearl J, Poundstone W, Sara Imari Walker, Schrödinger E, Segré D, Shaprio R, von Neumann J, Walker SI, Whitesides G   +20 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The skewness of science in 219 sub-fields and a number of aggregates [PDF]

This paper studies evidence from Thomson Scientific about the citation process of 3.7 million articles published in the period 1998-2002 in 219 Web of Science categories, or sub-fields.
Ignacio Ortuño, Javier Ruiz-Castillo, Juan A. Crespo, Pedro Albarrán   +3 more
core   +3 more sources

Florida marine biotechnology: research, development and training capabilities to advance science and commerce [PDF]

, 2001
The level of activity and interest in “marine biotechnology” among Florida university faculty and allied laboratory scientists is reported in this document.
Seaman, William, Whitehouse, Jacquelyn H.   +1 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mutations, Differential Gene Expression, and Chimeric Transcripts in Esophageal Squamous Cell Carcinoma Show High Heterogeneity

Translational Oncology, 2018
Esophageal squamous cell carcinoma (ESCC) is a frequent and lethal neoplasia. As recent advances in targeted therapy have not improved ESCC prognosis, characterization of molecular alterations associated to this tumor is of foremost relevance.
Paulo Thiago de Souza-Santos, Sheila Coelho Soares Lima, Pedro Nicolau-Neto, Mariana Boroni, Nathalia Meireles Da Costa, Lilian Brewer, Albert Nobre Menezes, Carolina Furtado, Miguel Angelo Martins Moreira, Hector N. Seuanez, Tatiana de Almeida Simão, Luis Felipe Ribeiro Pinto   +11 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source