Results 91 to 100 of about 352,777 (258)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A European database of Fusarium graminearum and F. culmorum trichothecene genotypes

Frontiers in Microbiology, 2016
Fusarium species, particularly Fusarium graminearum and F. culmorum, are the main cause of trichothecene type B contamination in cereals. Data on the distribution of Fusarium trichothecene genotypes in cereals in Europe are scattered in time and space ...
Matias ePasquali, Marco eBeyer, Antonio eLogrieco, Kris eAudenaert, Virgilio eBalmas, Ryan eBasler, Anne-Laure eBoutigny, Jana eChrpová, Elżbieta eCzembor, Tatiana eGagkaeva, María Teresa eGonzález-Jaén, Ingerd Skow eHofgaard, Nagehan Desen eKöycü, Lucien eHoffmann, Jelena eLević, Patricia Marín eGarcía, Thomas eMiedaner, Quirico eMigheli, Antonio eMoretti, Marina Elsa Herta eMüller, Françoise eMunaut, Päivi eParikka, Marine ePallez-Barthel, Jonathan ePiec, Jonathan eScauflaire, Barbara eScherm, Slavica eStanković, Ulf eThrane, Silvio eUhlig, Adriaan eVanheule, Tapani eYli-Mattila, Susanne eVogelgsang   +31 more
doaj   +1 more source

Beyond DNA: Epigenetics and Proteomics in Forensic Science [PDF]

, 2016
The use of genetic evidence in criminal cases is well established and has improved the public opinion and credibility of forensic science. However, several shortcomings associated with current genetic profiling techniques exist. Scientific research aimed
Eilerts, Diane F
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment

Genome Medicine
Background Monocytes are recruited to tumors and undergo transcriptional reprogramming resulting in tumor-promoting functions. Epigenomic features, such as post-translational modification of histones and chromatin accessibility, are key determinants of ...
Máté Kiss, Laszlo Halasz, Eva Hadadi, Wilhelm K. Berger, Petros Tzerpos, Szilard Poliska, Daliya Kancheva, Aurélie Gabriel, Romina Mora Barthelmess, Ayla Debraekeleer, Jan Brughmans, Yvon Elkrim, Liesbet Martens, Yvan Saeys, Bence Daniel, Zsolt Czimmerer, Damya Laoui, Laszlo Nagy, Jo A. Van Ginderachter   +18 more
doaj   +1 more source

Sustainability and groundwater in the context of Water-Energy-Food Nexus: a review of the literature

Derbyana
The sustainability of groundwater is contingent upon the Water-Energy-Food Nexus. In this context, the article aimed to analyze the state of the art in this field by using the Scopus database and the following keywords: “Sustainability”, “Nexus”, and ...
Sandra Milena Vélez Echeverry, Adriana Marques, Sueli Yoshinaga Pereira   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Targeting ubiquitin-specific protease 14 reduces metastatic potential and metabolic activity in cervical cancer via direct modulation of monocarboxylate transporter-4

Journal of Translational Medicine
Background Cervical cancer (CC) remains a major health burden in low- and middle-income countries, where HPV vaccination coverage is suboptimal. Ubiquitin-specific peptidase 14 (USP14), a proteasome-associated deubiquitinase, has emerged as a potential ...
Ravi Chauhan, Gunjan Dagar, Lakshay Malhotra, Ashna Gupta, Anju Surendranath, Harshul Kapoor, Hemant Yadav, Rajat Ujjainiya, Suraja Kumar Das, Sameer Mirza, Mukesh Tanwar, Pranay Tanwar, Abdul S. Ethayathulla, Archana Singh, Muzafar A. Macha, Shahab Uddin, Ammira S. Al-Shabeeb Akil, Sandeep Mathur, Tej K. Pandita, Ajaz A. Bhat, Mayank Singh   +20 more
doaj   +1 more source