Results 11 to 20 of about 352,777 (258)

Esperanto for histones : CENP-A, not CenH3, is the centromeric histone H3 variant [PDF]

, 2013
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease.
A. D. McAinsh, A. Desai, A. F. Straight, A. Losada, A. Musacchio, B. A. Sullivan, B. E. Black, B. G. Mellone, B. R. Brinkley, BA Sullivan, C. E. Sunkel, C. E. Walczak, CJ Lawrence, D. Foltz, D. M. Glover, D. W. Cleveland, D. W. Gerlich, DK Palmer, DR Foltz, E. D. Salmon, ES Alnemri, G. J. Gorbsky, G. J. P. L. Kops, G. Karpen, G. P. Copenhaver, H. F. Willard, H. Maiato, H. Masumoto, I. M. Cheeseman, J Ohzeki, J. G. DeLuca, J. R. Swedlow, K. Bloom, K. C. Scott, K. F. Sullivan, K. H. A. Choo, K. Luger, K. Oegema, K. Yoda, KF Sullivan, L. E. T. Jansen, L. Wordeman, M. A. Lampson, M. Fitzgerald-Hayes, M. Yanagida, MD Blower, P. E. Warburton, P. Heun, P. Meraldi, P. S. Maddox, P. T. Stukenberg, PB Talbert, R. C. Allshire, R. Gassmann, R. J. O’Neill, R. L. Margolis, S Ando, S Henikoff, S Stoler, S. C. Harrison, S. Diekmann, S. Erhardt, S. M. Lens, S. Westermann, SA Ribeiro, T Hori, T Nishino, T. Fukagawa, T. Hirota, T. J. Yen, W. Brown, W. C. Earnshaw, WC Earnshaw   +72 more
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p53 Mediates Vast Gene Expression Changes That Contribute to Poor Chemotherapeutic Response in a Mouse Model of Breast Cancer

Translational Oncology, 2018
p53 is a transcription factor that regulates expression of genes involved in cell cycle arrest, senescence, and apoptosis. TP53 harbors mutations that inactivate its transcriptional activity in roughly 30% of breast cancers, and these tumors are much ...
Crystal Tonnessen-Murray, Nathan A. Ungerleider, Sonia G. Rao, Amanda R. Wasylishen, Wesley D. Frey, James G. Jackson   +5 more
doaj   +1 more source

Bibliometric analysis of evolutionary trends and hotspots of super-enhancers in cancer

Frontiers in Pharmacology, 2023
Introduction: In the past decade, super-enhancer (SE) has become a research hotspot with increasing attention on cancer occurrence, development, and prognosis.
Zhen-Chu Tang, Zhen-Chu Tang, Qiang Qu, Qiang Qu, Qiang Qu, Qiang Qu, Xin-Qi Teng, Hai-Hui Zhuang, Wei-Xin Xu, Jian Qu   +9 more
doaj   +1 more source

Signal Integration of IFN-I and IFN-II With TLR4 Involves Sequential Recruitment of STAT1-Complexes and NFκB to Enhance Pro-inflammatory Transcription

Frontiers in Immunology, 2019
Atherosclerosis is a chronic inflammatory disease of the blood vessels, characterized by atherosclerotic lesion formation. Vascular Smooth Muscle Cells (VSMC), macrophages (MΦ), and dendritic cells (DC) play a crucial role in vascular inflammation and ...
Anna Piaszyk-Borychowska, Lajos Széles, Attila Csermely, Hsin-Chien Chiang, Joanna Wesoły, Chien-Kuo Lee, Laszlo Nagy, Laszlo Nagy, Hans A. R. Bluyssen   +8 more
doaj   +1 more source

Selenoprotein gene nomenclature [PDF]

, 2016
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis.
Arn\ue9r, Elias S., Berry, Marla J., Bruford, Elspeth A., Burk, Raymond F., Carlson, Bradley A., Castellano, Sergi, Chavatte, Laurent, Conrad, Marcus, Copeland, Paul R., Diamond, Alan M., Driscoll, Donna M., Ferreiro, Ana, Floh\ue9, Leopold, Gladyshev, Vadim N, Green, Fiona R., Guig\uf3, Roderic, Handy, Diane E., Hatfield, Dolph L., Hesketh, John, Hoffmann, Peter R., Holmgren, Arne, Hondal, Robert J., Howard, Michael T., Huang, Kaixun, K\uf6hrle, Josef, Kim, Hwa Young, Kim, Ick Young, Krol, Alain, Kryukov, Gregory V., Lee, Byeong Jae, Lee, Byung Cheon, Lei, Xin Gen, Lescure, Alain, Liu, Qiong, Lobanov, Alexei V., Loscalzo, Joseph, Maiorino, Matilde, Mariotti, Marco, Prabhu, K. Sandeep, Rayman, Margaret P., Regina, Brigelius Floh\ue9, Rozovsky, Sharon, Salinas, Gustavo, Schmidt, Edward E., Schomburg, Lutz, Schweizer, Ulrich, Simonovi\u107, Miljan, Sunde, Roger A., Tsuji, Petra A., Tweedie, Susan, Ursini, Fulvio, Whanger, Philip D., Zhang, Yan   +52 more
core   +3 more sources

Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops. [PDF]

, 2017
Synthesis-dependent strand annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory non-crossover outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity.
Ede, Christopher, Freudenthal, Bret D, Gore, Steven K, Heyer, Wolf-Dietrich, Jenkins, Shirin S, Liu, Jie, Todd Washington, M, Veaute, Xavier, Wright, William D   +8 more
core   +3 more sources

Citation and Altmetric Status of Research Outputs of Tehran University of Medical Sciences During 2006-2020

Payesh, 2021
Objective(s): The purpose of this study was to investigate the citation status and presence of research outputs of Tehran University of Medical Sciences in social media in five subjects during the years 2006-2020. Methods: The study applied scientometric
amir ghasemiyan, fereshte nojavan, arezou danae niya   +2 more
doaj  

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Nature Communications, 2023
Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer protein alpha (PITPNA) stimulates activity of phosphatidylinositol (PtdIns) 4-OH kinase to produce
Yu-Te Yeh, Chandan Sona, Xin Yan, Yunxiao Li, Adrija Pathak, Mark I. McDermott, Zhigang Xie, Liangwen Liu, Anoop Arunagiri, Yuting Wang, Amaury Cazenave-Gassiot, Adhideb Ghosh, Ferdinand von Meyenn, Sivarajan Kumarasamy, Sonia M. Najjar, Shiqi Jia, Markus R. Wenk, Alexis Traynor-Kaplan, Peter Arvan, Sebastian Barg, Vytas A. Bankaitis, Matthew N. Poy   +21 more
doaj   +1 more source

Multicellularity in green algae: Upsizing in a walled complex.

Frontiers in Plant Science, 2014
Modern green algae constitute a large and diverse taxonomic assemblage that encompasses many multicellular phenotypes including colonial, filamentous and parenchymatous forms.
David S. Domozych, Catherine E. Domozych
doaj   +1 more source

Stochastic Physics, Complex Systems and Biology [PDF]

, 2012
In complex systems, the interplay between nonlinear and stochastic dynamics, e.g., J. Monod's necessity and chance, gives rise to an evolutionary process in Darwinian sense, in terms of discrete jumps among attractors, with punctuated equilibrium ...
A Lasota, B Alberts, B E Shapiro, C Bustamante, D A Beard, D Hanahan, D-Q Jiang, E V Koonin, H D I Abarbanel, H Ge, H Ge, H Ge, H Ge, H Ge, H Haken, H Qian, H Qian, H Qian, H Qian, H Qian, H Qian, H Qian, H Tong, H V Westerhoff, I Prigogine, J J Hopfield, J Knight, J Monod, J Wang, J Wang, J Wang, L Bertalanffy Von, L Cai, L Onsager, M B Elowitz, M C Mackey, M W Kirschner, N Wax, P Ao, P Ao, P Ao, P B Moore, R F Fox, R Phillips, W J Ewens, X-J Zhang   +45 more
core   +2 more sources