Results 11 to 20 of about 139,343 (219)

p53 Mediates Vast Gene Expression Changes That Contribute to Poor Chemotherapeutic Response in a Mouse Model of Breast Cancer

Translational Oncology, 2018
p53 is a transcription factor that regulates expression of genes involved in cell cycle arrest, senescence, and apoptosis. TP53 harbors mutations that inactivate its transcriptional activity in roughly 30% of breast cancers, and these tumors are much ...
Crystal Tonnessen-Murray, Nathan A. Ungerleider, Sonia G. Rao, Amanda R. Wasylishen, Wesley D. Frey, James G. Jackson   +5 more
doaj   +1 more source

Bibliometric analysis of evolutionary trends and hotspots of super-enhancers in cancer

Frontiers in Pharmacology, 2023
Introduction: In the past decade, super-enhancer (SE) has become a research hotspot with increasing attention on cancer occurrence, development, and prognosis.
Zhen-Chu Tang, Zhen-Chu Tang, Qiang Qu, Qiang Qu, Qiang Qu, Qiang Qu, Xin-Qi Teng, Hai-Hui Zhuang, Wei-Xin Xu, Jian Qu   +9 more
doaj   +1 more source

Signal Integration of IFN-I and IFN-II With TLR4 Involves Sequential Recruitment of STAT1-Complexes and NFκB to Enhance Pro-inflammatory Transcription

Frontiers in Immunology, 2019
Atherosclerosis is a chronic inflammatory disease of the blood vessels, characterized by atherosclerotic lesion formation. Vascular Smooth Muscle Cells (VSMC), macrophages (MΦ), and dendritic cells (DC) play a crucial role in vascular inflammation and ...
Anna Piaszyk-Borychowska, Lajos Széles, Attila Csermely, Hsin-Chien Chiang, Joanna Wesoły, Chien-Kuo Lee, Laszlo Nagy, Laszlo Nagy, Hans A. R. Bluyssen   +8 more
doaj   +1 more source

Citation and Altmetric Status of Research Outputs of Tehran University of Medical Sciences During 2006-2020

Payesh, 2021
Objective(s): The purpose of this study was to investigate the citation status and presence of research outputs of Tehran University of Medical Sciences in social media in five subjects during the years 2006-2020. Methods: The study applied scientometric
amir ghasemiyan, fereshte nojavan, arezou danae niya   +2 more
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Multicellularity in green algae: Upsizing in a walled complex.

Frontiers in Plant Science, 2014
Modern green algae constitute a large and diverse taxonomic assemblage that encompasses many multicellular phenotypes including colonial, filamentous and parenchymatous forms.
David S. Domozych, Catherine E. Domozych
doaj   +1 more source

Long Non-Coding RNAs ANRIL and HOTAIR Upregulation is Associated with Survival in Neonates with Sepsis in a Neonatal Intensive Care Unit

International Journal of General Medicine, 2022
Nouran B AbdAllah,1 Essam Al Ageeli,2 Abdullah Shbeer,3 Jawaher A Abdulhakim,4 Eman A Toraih,5,6 Doaa O Salman,6 Manal S Fawzy,7,8 Sanaa S Nassar1 1Department of Pediatrics, Faculty of Medicine, Suez Canal University, Ismailia, Egypt; 2Department of ...
AbdAllah NB, Al Ageeli E, Shbeer A, Abdulhakim JA, Toraih EA, Salman DO, Fawzy MS, Nassar SS   +7 more
doaj  

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Nature Communications, 2023
Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer protein alpha (PITPNA) stimulates activity of phosphatidylinositol (PtdIns) 4-OH kinase to produce
Yu-Te Yeh, Chandan Sona, Xin Yan, Yunxiao Li, Adrija Pathak, Mark I. McDermott, Zhigang Xie, Liangwen Liu, Anoop Arunagiri, Yuting Wang, Amaury Cazenave-Gassiot, Adhideb Ghosh, Ferdinand von Meyenn, Sivarajan Kumarasamy, Sonia M. Najjar, Shiqi Jia, Markus R. Wenk, Alexis Traynor-Kaplan, Peter Arvan, Sebastian Barg, Vytas A. Bankaitis, Matthew N. Poy   +21 more
doaj   +1 more source

Application of a new dual localization-affinity purification tag reveals novel aspects of protein kinase biology in Aspergillus nidulans.

PLoS ONE, 2014
Filamentous fungi occupy critical environmental niches and have numerous beneficial industrial applications but devastating effects as pathogens and agents of food spoilage.
Colin P De Souza, Shahr B Hashmi, Aysha H Osmani, Stephen A Osmani   +3 more
doaj   +1 more source

Integration of CRISPR/Cas9 with artificial intelligence for improved cancer therapeutics

Journal of Translational Medicine, 2022
Gene editing has great potential in treating diseases caused by well-characterized molecular alterations. The introduction of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)–based gene-editing tools ...
Ajaz A. Bhat, Sabah Nisar, Soumi Mukherjee, Nirmalya Saha, Nageswari Yarravarapu, Saife N. Lone, Tariq Masoodi, Ravi Chauhan, Selma Maacha, Puneet Bagga, Punita Dhawan, Ammira Al-Shabeeb Akil, Wael El-Rifai, Shahab Uddin, Ravinder Reddy, Mayank Singh, Muzafar A. Macha, Mohammad Haris   +17 more
doaj   +1 more source

COVID-19 associated coagulopathy: A bibliometric investigation

Heliyon, 2023
Infection with SARS-CoV-2 initiates an immune-hemostatic response. While both systems are intimately connected and necessary for an efficient immune response to contain the infection, excessive coagulation activation might exceed the valuable benefits by
Nahla A. Alshaikh
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