Results 21 to 30 of about 133,000 (268)

Application of a new dual localization-affinity purification tag reveals novel aspects of protein kinase biology in Aspergillus nidulans.

PLoS ONE, 2014
Filamentous fungi occupy critical environmental niches and have numerous beneficial industrial applications but devastating effects as pathogens and agents of food spoilage.
Colin P De Souza, Shahr B Hashmi, Aysha H Osmani, Stephen A Osmani   +3 more
doaj   +1 more source

Integration of CRISPR/Cas9 with artificial intelligence for improved cancer therapeutics

Journal of Translational Medicine, 2022
Gene editing has great potential in treating diseases caused by well-characterized molecular alterations. The introduction of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)–based gene-editing tools ...
Ajaz A. Bhat, Sabah Nisar, Soumi Mukherjee, Nirmalya Saha, Nageswari Yarravarapu, Saife N. Lone, Tariq Masoodi, Ravi Chauhan, Selma Maacha, Puneet Bagga, Punita Dhawan, Ammira Al-Shabeeb Akil, Wael El-Rifai, Shahab Uddin, Ravinder Reddy, Mayank Singh, Muzafar A. Macha, Mohammad Haris   +17 more
doaj   +1 more source

Spotlight on Exosomal Non-Coding RNAs in Breast Cancer: An In Silico Analysis to Identify Potential lncRNA/circRNA-miRNA-Target Axis [PDF]

, 2022
Breast cancer (BC) has recently become the most common cancer type worldwide, with metastatic disease being the main reason for disease mortality. This has brought about strategies for early detection, especially the utilization of minimally invasive ...
Alwan, Nisreen, Nasr, Rihab, Ayman Al Shoukari, Chamandi, Ghada, Nasr, Rihab R., Samira Abdallah, Alwan, Nisreen H., Shoukari, Ayman Al, Ghada Chamandi, Choubassy, Hayat, Abdul Rahman S. Itani, Rihab Nasr, Nisreen Alwan, Ohanes Ashekyan, Abdallah, Samira, Ashekyan, Ohanes, Chamandi, Ghada K., Itani, Abdul Rahman S., Itani, Abdulrahman S., Hayat Choubassy   +19 more
core   +1 more source

COVID-19 associated coagulopathy: A bibliometric investigation

Heliyon, 2023
Infection with SARS-CoV-2 initiates an immune-hemostatic response. While both systems are intimately connected and necessary for an efficient immune response to contain the infection, excessive coagulation activation might exceed the valuable benefits by
Nahla A. Alshaikh
doaj   +1 more source

Biochemistry, molecular biology, and genetics of the oligosaccharyltransferase

, 2008
Asparagine-linked glycosylation is a highly conserved protein modification reaction that occurs in all eukaryotes. The initial stage in the biosynthesis of N-linked glycoproteins, catalyzed by the enzyme oligosaccharyltransferase (OST), involves the ...
Gilmore, Reid, Silberstein, Susana
core   +1 more source

A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes [PDF]

, 2013
peer reviewedWe present an experimental and computational pipeline for the generation of kinetic models of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae. Starting from an approximate mathematical model, we employ a
Carroll, Kathleen M, Paton, Norman W, Mendes, Pedro, McCarthy, John E G, Carroll, K.M., Weichart, D., Broomhead, David S., Murabito, Ettore, Khan, Farid, Messiha, Hanan L.,, Dunn, Warwick B., Oliver, Stephen G,, Swainston, N., Broomhead, D. S., Dada, Joseph O., Oliver, Stephen G., Westerhoff, H.V.; id_orcid, Kell, Douglas B.,, Kell, D.B., Gaskell, Simon J, Winder, Catherine L., Malys, Naglis, Dada, J.O., Westerhoff, Hans V.,, Pir, P., Paton, N.W., Pendes, Pedro, Pir, Pınar,, Murabito, Ettore,, Messiha, H.L., Paton, Norman W., Westerhoff, Hans V., Gaskell, Simon J., Dunn, Warwick B.,, Simeonidis, E., Kell, Douglas B., Simeonidis, Evangelos,, Khan, Farid,, Jameson, Daniel; id_orcid, Gaskell, S.J., Jameson, Daniel, Dada, Joseph O, Carroll, Kathleen M.,, Spasić, I., Kell, Douglas B, Smallbone, K., Winder, Catherine L, Mendes, P., McCarthy, John E. G., Hayes, Neil W., Paton, Norman; id_orcid, Spasic, Irena, Weichart, Dieter, Pir, Pınar, Gaskell, S. J., Carroll, Kathleen M., Dunn, W.B., Jameson, Daniel,, Jameson, D., Gaskell, Simon J.,, Malys, N., Paton, Norman W.,, Malys, Naglis,, SIMEONIDIS, Vangelis, Smallbone, Kieran,, Simeonidis, Evangelos, Wishart, J., Messiha, Hanan L, Wishart, Jill,, Westerhoff, Hans V, McCarthy, John E G,, Murabito, E., Khan, F., Oliver, Stephen G, Wishart, Jill, Broomhead, David S, Messiha, Hanan L., Dunn, Warwick B, Winder, C.L., Jameson, D,, Dada, Joseph O.,, Swainston, Neil,, Weichart, Dieter,, Oliver, S. G., Hayes, N.W., Pir, Pinar, Spasić, Irena,, Broomhead, D.S., Mendes, Pedro,, Broomhead, David S.,, McCarthy, John E.G., Hayes, Neil W, Hayes, Neil W.,, Oliver, S.G., Swainston, Neil, Smallbone, Kieran, McCarthy, J.E.G., Winder, Catherine L.,, Westerhoff, H.V., Carroll, Kathleen M; id_orcid   +99 more
core   +1 more source

Distinct migratory and non-migratory ecotypes of an endemic New Zealand eleotrid (Gobiomorphus cotidianus) – implications for incipient speciation in island freshwater fish species [PDF]

, 2008
Background: Many postglacial lakes contain fish species with distinct ecomorphs. Similar evolutionary scenarios might be acting on evolutionarily young fish communities in lakes of remote islands.
Stoelting, K.N., Kai N Stölting, van den Heuvel, Michael, Clarke, Andrew C, Stevens, M.I., van den Heuvel, M.R., Brendan J Hicks, Meyer, Axel, Clarke, A.C., Stölting, Kai N, Hicks, Brendan J., Ray Tana, Stolting, Kai, Clarke, Andrew, Meyer, A., Tana, Raymond, Christian Michel, Heuvel, Michael R. van den, Tana, Ray, Michel, C., St�lting, Kai N, Hicks, B.J., Andrew C Clarke, Stevens, Mark I, van den Heuvel, Michael R, Mark I Stevens, Clarke, Andrew C., Hicks, Brendan, Tana, R., van den Heuvel, Michael R., Stevens, Mark Ian, Axel Meyer, Michael R van den Heuvel, Stevens, Mark I., Stölting, Kai N., Michel, Christian, Hicks, Brendan J   +36 more
core   +1 more source

Identification, Genome Sequencing, and Characterizations of Helicobacter pylori Sourced from Pakistan

Microorganisms, 2023
The stomach’s colonization by Helicobacter pylori (H. pylori) results in gastritis, ulcers, and stomach cancer. Frequently, pain is treated with medication, but resistant H. pylori infections are not.
Anees Fatima, Muhammad Ibrahim, Adil Naseer, Arshid Pervez, Muhammad Asad, Aamer Ali Shah, Fariha Hasan, Wadi B. Alonazi, Ifra Ferheen, Samiullah Khan   +9 more
doaj   +1 more source

Genomic and Biochemical Analysis of N Glycosylation in the Mushroom-Forming Basidiomycete Schizophyllum commune

, 2009
N-linked glycans of Schizophyllum commune consist of Man(5-9)GlcNAc(2) structures. Lack of further glycan maturation is explained by the absence of genes encoding such functions in this and other homobasidiomycetes.
de Jong, J.F., Jong, J.F., de, Wosten, H.A.B., Ohm, R.A., Bosch, G.B.M., van den, Molecular Microbiology, Lugones, L.G., Sub Molecular Microbiology, van den Bosch, G.B.M., Sub Membrane Biochemistry & Biophysics, Rouwendal, G.J.A., Bosch, D., Dep Scheikunde, Berends, E., Membrane Enzymology   +14 more
core   +1 more source

Towards Developmental Models of Psychiatric Disorders in Zebrafish

Frontiers in Neural Circuits, 2013
Psychiatric disorders are a diverse set of diseases that affect all aspects of mental function including social interaction, thinking, feeling and mood.
William Howard James Norton
doaj   +1 more source