Results 31 to 40 of about 352,777 (258)

Towards Developmental Models of Psychiatric Disorders in Zebrafish

Frontiers in Neural Circuits, 2013
Psychiatric disorders are a diverse set of diseases that affect all aspects of mental function including social interaction, thinking, feeling and mood.
William Howard James Norton
doaj   +1 more source

CAR-T-Cell Therapy in Multiple Myeloma: B-Cell Maturation Antigen (BCMA) and Beyond

Vaccines, 2023
Significant progress has been achieved in the realm of therapeutic interventions for multiple myeloma (MM), leading to transformative shifts in its clinical management.
Abhinava K. Mishra, Ashna Gupta, Gunjan Dagar, Dayasagar Das, Abhijit Chakraborty, Shabirul Haque, Chandra Prakash Prasad, Archana Singh, Ajaz A. Bhat, Muzafar A. Macha, Moez Benali, Kamal S. Saini, Rebecca Ann Previs, Deepak Saini, Dwaipayan Saha, Preyangsee Dutta, Aseem Rai Bhatnagar, Mrinalini Darswal, Abhishek Shankar, Mayank Singh   +19 more
doaj   +1 more source

Evolution of substrate specificity in a retained enzyme driven by gene loss. [PDF]

, 2017
The connection between gene loss and the functional adaptation of retained proteins is still poorly understood. We apply phylogenomics and metabolic modeling to detect bacterial species that are evolving by gene loss, with the finding that ...
Babnigg, Gyorgy, Barona-Gómez, Francisco, Carrillo-Tripp, Mauricio, Edirisinghe, Janaka N, Endres, Michael, Henry, Christopher S, Joachimiak, Andrzej, Juárez-Vázquez, Ana Lilia, Medina-Ruíz, Sofía, Michalska, Karolina, Noda-García, Lianet, Santoyo-Flores, Julián, Ton-That, Hung, Verduzco-Castro, Ernesto A, Wu, Chenggang   +14 more
core   +1 more source

T2D-Db: An integrated platform to study the molecular basis of Type 2 diabetes

BMC Genomics, 2008
Background Type 2 Diabetes Mellitus (T2DM) is a non insulin dependent, complex trait disease that develops due to genetic predisposition and environmental factors.
Sriram S, Lakshmi S Sai, Udayakumar K, Nathan Prasanthi, Dimitrova Nevenka, Agrawal Shipra, Manjusha N, Sengupta Urmi   +7 more
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

A new vector system for targeted integration and overexpression of genes in the crop pathogen Fusarium solani

Fungal Biology and Biotechnology, 2019
Background Besides their ability to produce several interesting bioactive secondary metabolites, members of the Fusarium solani species complex comprise important pathogens of plants and humans.
Mikkel Rank Nielsen, Anna Karolina Rilana Holzwarth, Emmett Brew, Natalia Chrapkova, Samba Evelyne Kabemba Kaniki, Kenneth Kastaniegaard, Trine Sørensen, Klaus Ringsborg Westphal, Reinhard Wimmer, Teis Esben Sondergaard, Jens Laurids Sørensen   +10 more
doaj   +1 more source

Educating the educators: Incorporating bioinformatics into biological science education in Malaysia [PDF]

, 2012
Bioinformatics can be defined as a fusion of computational and biological sciences. The urgency to process and analyse the deluge of data created by proteomics and genomics studies has caused bioinformatics to gain prominence and importance. However, its
Hussein, Huszalina, Mohd. Hashim, Siti Zaiton, Salim, Naomie, Shamsir, Mohd. Shahir   +3 more
core  

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Out of the Curricular Shadows: Revolutionizing Undergraduate Immunology Education

Frontiers in Immunology, 2019
Immunology has its developmental roots in understanding protection of the host from pathogens, leading to the development of vaccines and subsequently identification of soluble and cellular components of the immune system.
Heather A. Bruns, Jill Deaver, Louis B. Justement   +2 more
doaj   +1 more source