Results 31 to 40 of about 133,000 (268)

T2D-Db: An integrated platform to study the molecular basis of Type 2 diabetes

BMC Genomics, 2008
Background Type 2 Diabetes Mellitus (T2DM) is a non insulin dependent, complex trait disease that develops due to genetic predisposition and environmental factors.
Sriram S, Lakshmi S Sai, Udayakumar K, Nathan Prasanthi, Dimitrova Nevenka, Agrawal Shipra, Manjusha N, Sengupta Urmi   +7 more
doaj   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

CAR-T-Cell Therapy in Multiple Myeloma: B-Cell Maturation Antigen (BCMA) and Beyond

Vaccines, 2023
Significant progress has been achieved in the realm of therapeutic interventions for multiple myeloma (MM), leading to transformative shifts in its clinical management.
Abhinava K. Mishra, Ashna Gupta, Gunjan Dagar, Dayasagar Das, Abhijit Chakraborty, Shabirul Haque, Chandra Prakash Prasad, Archana Singh, Ajaz A. Bhat, Muzafar A. Macha, Moez Benali, Kamal S. Saini, Rebecca Ann Previs, Deepak Saini, Dwaipayan Saha, Preyangsee Dutta, Aseem Rai Bhatnagar, Mrinalini Darswal, Abhishek Shankar, Mayank Singh   +19 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Analysis of the meiotic segregation in intergeneric hybrids of tilapias [PDF]

, 2012
Tilapia species exhibit a large ecological diversity and an important propensity to interspecific hybridisation. This has been shown in the wild and used in aquaculture.
Chevassus-Au-Louis, Bernard, Baroiller, Jean-Francois, Rognon, Xavier, X, Gharbi, Karim, Bezault, Etienne, Rognon, Xavier,, Rognon, François, Chevassus, Bernard, Rognon, Xavier, Clota, Frederic   +9 more
core   +1 more source

Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications

, 2023
As recreational use of cannabis is being decriminalized in many places and medical use widely sanctioned, there are growing concerns about increases in cannabis use disorder (CanUD), which is associated with numerous medical comorbidities.
Hougaard, David M., Cooke, Megan, Kranzler, Henry R, Empke, Stefany L. L., Wendt, Frank, Bhattacharya, Arjun, Hougaard, David, Agrawal, Arpana, Empke, Stefany, Harrington, Kelly M, Edenberg, Howard, Wendt, Frank R, Kranzler, Henry R., Smoller, Jordan W., Polimanti, Renato, Koller, Dora, Gandal, Michael J, Gandal, Michael J., Stein, Murray, Harrington, Kelly M., Wendt, Frank R., Demontis, Ditte, Nunez, Yaira, Edenberg, Howard J., Johnson, Emma C., Deak, Joseph D., Gaziano, J Michael, Gandal, Michael, Stein, Murray B., Stein, Murray B, Børglum, Anders, Børglum, Anders D., Johnson, Emma, Smoller, Jordan W, Levey, Daniel F., Nunez, Yaira Z., Deak, Joseph, Rajagopal, Veera M., Rajagopal, Veera, Veterans Affairs Million Veteran Program, Deak, Joseph D, Lam, Max, Kranzler, Henry, Edenberg, Howard J, Harrington, Kelly, Gaziano, J, Zhou, Hang, Smoller, Jordan, Galimberti, Marco, Levey, Daniel F, Empke, Stefany L L, Quaden, Rachel, Nunez, Yaira Z, Levey, Daniel, Gupta, Priya, Lencz, Todd, Hougaard, David M, Biradar, Mahantesh, Gaziano, J. Michael, Børglum, Anders D, Johnson, Emma C, Rajagopal, Veera M, Gelernter, Joel   +62 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A new vector system for targeted integration and overexpression of genes in the crop pathogen Fusarium solani

Fungal Biology and Biotechnology, 2019
Background Besides their ability to produce several interesting bioactive secondary metabolites, members of the Fusarium solani species complex comprise important pathogens of plants and humans.
Mikkel Rank Nielsen, Anna Karolina Rilana Holzwarth, Emmett Brew, Natalia Chrapkova, Samba Evelyne Kabemba Kaniki, Kenneth Kastaniegaard, Trine Sørensen, Klaus Ringsborg Westphal, Reinhard Wimmer, Teis Esben Sondergaard, Jens Laurids Sørensen   +10 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Out of the Curricular Shadows: Revolutionizing Undergraduate Immunology Education

Frontiers in Immunology, 2019
Immunology has its developmental roots in understanding protection of the host from pathogens, leading to the development of vaccines and subsequently identification of soluble and cellular components of the immune system.
Heather A. Bruns, Jill Deaver, Louis B. Justement   +2 more
doaj   +1 more source