Results 51 to 60 of about 352,777 (258)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Molecular Targeting and Rational Chemotherapy in Acute Myeloid Leukemia

Journal of Experimental Pharmacology, 2020
Fatemeh Pourrajab,1,2 Mohamad Reza Zare-Khormizi,3 Seyedhossein Hekmatimoghaddam,4,5 Azam Sadat Hashemi4,6 1Nutrition and Food Security Research Centre, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; 2Department of Clinical Biochemistry and ...
Pourrajab F, Zare-Khormizi MR, Hekmatimoghaddam S, Hashemi AS   +3 more
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Insights into avian molecular cytogenetics—with reptilian comparisons

Molecular Cytogenetics
In the last 100 years or so, much information has been accumulated on avian karyology, genetics, physiology, biochemistry and evolution. The chicken genome project generated genomic resources used in comparative studies, elucidating fundamental ...
Darren K. Griffin, Rafael Kretschmer, Kornsorn Srikulnath, Worapong Singchat, Rebecca E. O’Connor, Michael N. Romanov   +5 more
doaj   +1 more source

Obesity and Hypertension in Students of Jahangirnagar University: Alarming Issues [PDF]

, 2015
The prevalence of obesity and hypertension (HTN) in university students of Bangladesh has not reported yet. Considering the proper health maintenance of this population in mind, the study was aimed to determine the prevalence of obesity and HTN as well ...
Biswas, P. (Puja), Hossain, M. S. (Md), Paul, S. (Sudip), Saha, M. (Moumoni), Solayman, M. (Md)   +4 more
core  

Yeasts [PDF]

, 2018
Yeasts are a group of eukaryotic microfungi with a well-defined cell wall whose growth is either entirely unicellular or a combination of hyphal and unicellular reproduction. The approximately 1500 known yeast species belong to two distinct fungal phyla,
Lachance, Marc-Andre, Walker, Graeme M.
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Students’ perspectives and expectations on the planning phase of elective postings in phase III of the MBBS program [PDF]

Research and Development in Medical Education
Background: The National Medical Council (NMC) in its new Curriculum Based Medical Education (CBME) has mandated four weeks of elective postings for phase III part II MBBS students of 2019 batch. Each student will undergo two weeks of training in block-1
Dhivya Manickam, Jeevithan Shanmugam, Sridhar MG, Blesson S. Fogarty, Akshay Kumar   +4 more
doaj   +1 more source

Reduction [PDF]

, 2016
Reduction and reductionism have been central philosophical topics in analytic philosophy of science for more than six decades. Together they encompass a diversity of issues from metaphysics and epistemology.
Hüttemann, Andreas, Love, Alan
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source