Results 61 to 70 of about 368,095 (294)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Students’ perspectives and expectations on the planning phase of elective postings in phase III of the MBBS program [PDF]

Research and Development in Medical Education
Background: The National Medical Council (NMC) in its new Curriculum Based Medical Education (CBME) has mandated four weeks of elective postings for phase III part II MBBS students of 2019 batch. Each student will undergo two weeks of training in block-1
Dhivya Manickam, Jeevithan Shanmugam, Sridhar MG, Blesson S. Fogarty, Akshay Kumar   +4 more
doaj   +1 more source

Beyond DNA: Epigenetics and Proteomics in Forensic Science [PDF]

, 2016
The use of genetic evidence in criminal cases is well established and has improved the public opinion and credibility of forensic science. However, several shortcomings associated with current genetic profiling techniques exist. Scientific research aimed
Eilerts, Diane F
core   +1 more source

A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms [PDF]

, 2004
We describe a genetic variation map for the chicken genome containing 2.8 million single-nucleotide polymorphisms ( SNPs). This map is based on a comparison of the sequences of three domestic chicken breeds ( a broiler, a layer and a Chinese silkie) with
Aerts, Andrea, Andersson, Björn, Andersson, Leif, Bartley, Neil, Boardman, Paul E, Bovenhuis, Henk, Brandström, Mikael, Bumstead, Nat, Burt, David W, Chen, Chen, Chen, Jie, Cheng, Hans H, Consortium, International Chicken Polymorphism Map, Crooijmans, Richard P M A, Dai, Mingtao, de Koning, Dirk-Jan, Dong, Le, Dong, Wei, Ellegren, Hans, Glavina, Tijana, Gordon, Laurie, Groenen, Martien A M, Gunnarsson, Ulrika, Hao, Bailin, He, Dandan, He, Ximiao, Hillier, Ladeana W, Hocking, Paul M, Hu, Songnian, Huang, Xiangang, Huang, Yanqing, Hubbard, Simon J, Hunt, Henry, Kaiser, Pete, Kaufman, Jim, Kindlund, Ellen, Lamont, Susan J, Lan, Fengdi, Law, Andy, Li, Dawei, Li, Guangyuan, Li, Guoqing, Li, Heng, Li, Jun, Li, Ning, Li, Ruiqiang, Li, Shengting, Li, Songgang, Li, Wenjie, Li, Yuanzhe, Lin, Wei, Liu, Bin, Lucas, Susan, Meng, Qingshun, Morrice, David, Ni, Peixiang, Ovcharenko, Ivan, Overton, Ian M, Ponting, Chris, Qi, Qiuhui, Ran, Longhua, Rogers, Sally, Rothwell, Lisa, Ruan, Jue, Shi, Jianping, Stubbs, Lisa, Sun, Yongqiao, Tammi, Martti T, Tang, Haizhou, Tong, Wei, van der Poel, Jan J, van Hateren, Andy, Wahlberg, Per, Walker, Brian A, Wang, Jian, Wang, Jianjun, Wang, Jing, Wang, Jun, Wang, Miaoheng, Wang, Pei, Wang, Xiaoling, Warren, Wesley C, Webber, Caleb, Wei, Dong Qing, Wei, Ning, Wilson, Richard K, Wilson, Stuart A, Wong, Gane Ka-Shu, Xi, Yan, Xie, Fei, Yang, Huanming, Yang, Ning, Yang, Shiaw-Pyng, Yang, Xu, Yang, Zheng, Ye, Chen, Ye, Jia, Young, John R, Yu, Jun, Yu, Yingpu, Zeng, Changqing, Zhang, Jianguo, Zhang, Jingjing, Zhang, Xiaowei, Zhang, Yunze, Zhang, Zengjin, Zhang, Zhenpeng, Zhang, Zhi-Yong, Zhao, Wenming, Zhao, Yiqiang, Zheng, Hongkun, Zheng, Weimou, Zhou, Huaijun, Zhou, Jun, Zhou, Yan   +114 more
core   +3 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

A bibliometric study on Sordariales fungi covering genetic diversity, ecological interactions and biotechnological applications [PDF]

Global Journal of Environmental Science and Management
The kingdom fungi, with its vast diversity and applications, is crucial in maintaining ecosystem balance and supporting industries like food production and environmental protection.
N.F. Wulandari, A.R. Syam, L. Alhamd, B. Gunadi, Yosmaniar ,, E. Widjaja, B.N. Utomo, S. Wahyuwardani, R. Widiastuti, T. Kadarini, D. Safar   +10 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism

Neoplasia: An International Journal for Oncology Research, 2019
SIRT3 is a major mitochondrial deacetylase, which regulates various metabolic pathways by deacetylation; however, the effect of SIRT3 on proline metabolism is not reported.
Shuaiyi Chen, Xin Yang, Miao Yu, Zhe Wang, Boya Liu, Minghui Liu, Lu Liu, Mengmeng Ren, Hao Qi, Junhua Zou, Ivana Vucenik, Wei-Guo Zhu, Jianyuan Luo   +12 more
doaj   +1 more source

RGC1/RGC2 deletions cause increased sensitivity to oxidative stress in Saccharomyces cerevisiae, which can be overcome by constitutive nuclear Yap1 expression [PDF]

, 2016
Oxidative stress mechanism in yeast presents an innovative pathway to understand in creating the next generation of antifungal drugs. Rgc1 and Rgc2 are paralogous proteins that regulate the Fps1 glycerol channel in hyperosmotic stress.
Tsai, Michelle
core   +1 more source