Results 51 to 60 of about 1,282,096 (340)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Artificial intelligence driven innovations in biochemistry: A review of emerging research frontiers

Biomolecules & Biomedicine
Artificial intelligence (AI) has become a powerful tool in biochemistry, greatly enhancing research capabilities by enabling the analysis of complex datasets, predicting molecular interactions, and accelerating drug discovery. As AI continues to evolve,
Mohammed Abdul Lateef Junaid
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Assessment of changes in clinical and biochemical indicators of saliva at caries according to monitoring [PDF]

Саратовский научно-медицинский журнал, 2013
The research goal was to determine the variability in the salivary characteristics, depending on the season, identifying the most important indicators of the salivary characteristics at different degrees of intensity of caries process and the ...
Albitskaya J.N., Bulkina N.V., Vulakh N.A., Kropotina A.Yu., Polosukhina E.N., Guseva O.Yu., Parfyonova S.V.   +6 more
doaj  

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

Biological Reviews of The Cambridge Philosophical Society, 2014
The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism. The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide and amino acid biosynthesis, to provide reducing molecules for anabolism ...
Anna Stincone, A. Prigione, T. Cramer, M. Wamelink, Kate Campbell, E. Cheung, V. Olin-Sandoval, Nana-Maria Grüning, Antje Krüger, M. Alam, M. Keller, M. Breitenbach, K. Brindle, J. Rabinowitz, M. Ralser   +14 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Radial variation in biochemical composition of the bovine caudal intervertebral disc

JOR Spine, 2019
Bovine caudal discs have been widely used in spine research due to their increased availability, large size, and mechanical and biochemical properties that are comparable to healthy human discs. However, despite their extensive use, the radial variations
Semih E. Bezci, Benjamin Werbner, Minhao Zhou, Katerina G. Malollari, Gabriel Dorlhiac, Carlo Carraro, Aaron Streets, Grace D. O'Connell   +7 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Assessing the stability of uncentrifuged serum and plasma analytes at various post-collection intervals

Journal of Laboratory Medicine
Our study aimed to assess the stability of 26 biochemistry analytes in serum or plasma samples separated from blood samples centrifuged at different time intervals after collection, simulating sample transport via despatch delivery systems.
Mokhsin Atiqah, Subramaniam Poonaresi, Sivaneson Sivasooriar, Nheu Nelson, Ramaloo Gobhy, Hanifah Azana S., Mahathevan Sumitha B., Nadarajah Mohanaraja, Sampasivam Gayathiri, Mohd Ismail Aletza, Abdul Rahman Thuhairah   +10 more
doaj   +1 more source