Results 61 to 70 of about 1,229,349 (338)
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
The study of biochemistry, particularly the exploration of biomolecules and metabolic pathways, stands at the crossroads of various scientific disciplines, including biology, chemistry, and medicine. This book, Biomolecules and Metabolic Pathways: Fundamentals, Bioenergetics, and Genetic Information Processing, is an effort to synthesise the vast and ...
Dr. Sanjeev kumar +4 more
openaire +2 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Characterisation of the bacterial biosensor GMG in E-coli BL21 (DE3)
Engineering Biology, 2018 In this work, a gold biosensor has been constructed and characterised in Escherichia coli (E. coli). Though gold biosensors have been previously reported, a NOT gate gold biosensing genetic circuit was constructed using an orthogonal inverter system as ...
Rashmi Rajasabhai +2 more
doaj +1 more source
Clinica Chimica Acta, 2020 Infertility affects approximately 186 million people worldwide and 8-12% of couples of reproductive age. Therefore, a comprehensive diagnostic evaluation of infertility is crucial to achieving improvements in targeted prevention and treatment outcomes.
T. Wasilewski +3 more
openaire +3 more sources
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Evolution des acides aminés libres dans le moût de raisin sous l'action des levures de fleur
OENO One, 1974 La connaissance des composés azotés du moût de raisin, en parti¬ culier celle des acides aminés, présente un grand intérêt en raison de leur rôle nutritionnel vis-à-vis des levures qui effectuent la fermentation alcoolique ; ils sont également les ...
M.C. POLO, C. LLAGUNO
doaj +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Biological Reviews of The Cambridge Philosophical Society, 2014 The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism. The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide and amino acid biosynthesis, to provide reducing molecules for anabolism ...
Anna Stincone +14 more
semanticscholar +1 more source