Results 111 to 120 of about 164,527 (299)
The Role of biotransformation in drug development
This book provides the basic concepts of biotransformation and its applications in the fields of pharmaceutical and food industries, as well as in drug development.
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Statistical Procedures for Finding Distribution Fits over Datasets with Applications in Biochemistry [PDF]
Bioautomation, 2009 A common problem in statistics is finding a distribution that fits to a certain dataset. Many theoretical distributions have been developed to give a good description of the empirical observations, and consequently, theory offers a variety of algorithms ...
Daniela S. Toneva +2 more
doaj
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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, 2021 Friday, October 8, 2021, 3:00 p.m.; Chem 200; Dr. Surya Banks, Assistant Professor, Department of Chemistry & Biochemistry, The College of St. ScholasticaThe extent of synthetic organic chemistry is pervasive in every aspect of our society today. However,
Banks, Surya +1 more
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FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
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Effects of intensive mariculture on sediment biochemistry
, 2007 The exponential growth of off-shore mariculture that has occurred worldwide over the last 10 years has raised concern about the impact of the waste produced by this industry on the ecological integrity of the sea bottom.
DANOVARO R. +6 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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Applications of sequence coevolution in membrane protein biochemistry
, 2018 Recently, protein sequence coevolution analysis has matured into a predictive powerhouse for protein structure and function. Direct methods, which use global statistical models of sequence coevolution, have enabled the prediction of membrane and ...
Rachelle Gaudet +3 more
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