Results 81 to 90 of about 1,093 (175)
iScience, 2020 Summary: Tool use is a striking aspect of animal behavior, but it is hard to infer how the capacity for different types of tool use emerged across animal taxa.
Iain G. Johnston, Ellen C. Røyrvik
doaj +1 more source
Protein–ligand binding affinity prediction with edge awareness and supervised attention
iScience, 2023 Summary: Accurate prediction of protein–ligand binding affinity is crucial in structure-based drug design but remains some challenges even with recent advances in deep learning: (1) Existing methods neglect the edge information in protein and ligand ...
Yuliang Gu +9 more
doaj +1 more source
Function vs. Taxonomy: The Case of Fungi Mitochondria ATP Synthase Genes [PDF]
, 2020 We studied the relations between triplet composition of the family of mitochondrial atp6, atp8 and atp9 genes, their function, and taxonomy of the bearers. The points in 64-dimensional metric space corresponding to genes have been clustered. It was found
Колесникова, Анна Дмитриевна +4 more
core +1 more source
Engineered Bacteria as Living Biosensors in Dermal Tattoos
Advanced Science, Volume 11, Issue 30, August 14, 2024.Tattoo based biosensors are systems that use skin as a diagnostic interface for biomarker monitoring. In this article, engineered bacteria biosensors are interfaced into dermal tattoos through the embedding of bacteria into microgels generated through microfluidics.
Matthew E. Allen +6 more
wiley +1 more source
ACKR3 in olfactory glia cells shapes the immune defense of the olfactory mucosa
Glia, Volume 72, Issue 6, Page 1183-1200, June 2024.Main Points Olfactory sustentacular cells express the atypical chemokine receptor ACKR3. ACKR3 cKO increases the expression of immune defense genes in sustentacular cells and Bowman’s glands. ACKR3 cKO leads to leukocyte recruitment to the olfactory mucosa.
André Dietz, Katja Senf, Eva M. Neuhaus
wiley +1 more source
FEBS Open Bio, Volume 14, Issue 4, Page 655-674, April 2024.Enzyme kinetic studies of rat multifunctional enzyme, type‐1 (RnMFE1) (monomeric, two active sites: ECH, HAD) and human 3S‐hydroxyacyl‐CoA dehydrogenase (HsHAD) (dimeric, one active site: HAD) show that RnMFE1 is a slower dehydrogenase than HsHAD. It is discussed that the different assembly and predicted different flexibility properties of MFE1 (curved
Shruthi Sridhar +4 more
wiley +1 more source
FEBS Letters, Volume 598, Issue 6, Page 621-634, March 2024.In recent years, there is increasing evidence to suggest that matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI‐MSI) technology could offer support in clinical decision‐making processes. Here, we discuss some of the recent technical developments underpinning this progress and outline some of the more promising clinical ...
Isabella Piga +2 more
wiley +1 more source
Tissue niches and immunopathology through the lens of spatial tissue profiling techniques
European Journal of Immunology, Volume 54, Issue 2, February 2024.Spatial tissue profiling techniques identify a large number of proteins and/or genes within tissues, enabling in situ cell type and cell state identification and cell communication analysis. From a spatial immunology perspective, these techniques may reveal the role of distinct tissue niches in modulating local immune responses and directing tissue ...
Anna Pascual‐Reguant +2 more
wiley +1 more source
DNA logic programming: From concept to construction
VIEW, Volume 5, Issue 1, February 2024.DNA logic gates in the application domain of DNA nanostructures play a crucial role in discerning and quantifying the authenticity of events, thereby establishing self‐driven control over event feedback. Building upon this foundation, DNA logic circuits, which integrate multiple independent DNA logic gates, enable autonomous assessment of complex ...
Yi Zhang, Ning Hu, Jiajie Xu, Zhen Wang
wiley +1 more source
The FEBS Journal, Volume 291, Issue 4, Page 705-721, February 2024.The plant pathogen Xanthomonas campestris is characterized by a complex membrane lipid composition with various headgroups and fatty acids (FA). Bacteria incorporate FAs into membrane lipids through a two‐step acylation of glycerol‐3‐phosphate to phosphatidic acid, with PlsC enzymes driving the second acylation.
Georgios Vasilopoulos +10 more
wiley +1 more source