Results 61 to 70 of about 768 (137)
Ymir: A 3D structural affinity model for multi-epitope vaccine simulations
iScience, 2021 Summary: Vaccine development is challenged by the hierarchy of immunodominance between target antigen epitopes and the emergence of antigenic variants by pathogen mutation.
Philippe A. Robert +2 more
doaj +1 more source
, 2021 Introduction: Amputees may be eligible to use a socket or osseointegrated (OI) prosthesis after losing a limb. A lot is known about the stump-socket interface in transtibial (TT) amputees.
van den Broek, Annemiek (author)
core
Molecular Nutrition &Food Research, Volume 68, Issue 24, December 2024.Human milk (HM) is a complex fluid rich in nutrients and bioactive compounds. This study analysed the HM metabolite profile of 123 healthy women and detected 432 different metabolites. These metabolites were clustered into three distinct groups, mainly driven by differences in triglyceride concentrations. C‐section, breastfeeding practices and maternal
Joaquim Calvo‐Lerma +7 more
wiley +1 more source
Molecular Oncology, Volume 18, Issue 10, Page 2524-2540, October 2024.The machinery that carries out maturation of RNA, the spliceosome, is severely altered in pancreatic ductal adenocarcinoma. Decreased expression of two splicing factors, PRPF8 and RBMX, is linked to aggressiveness features and poor survival, while their rescue improves cell behavior.
Emilia Alors‐Pérez +19 more
wiley +1 more source
Database of recurrent mutations, an unbiased web resource to browse recurrent mutations in cancers
iScienceSummary: Existing cancer-associated variant databases contain biases arising from duplicate entries and the inclusion of targeted sequencing panels, which interfere with accurate estimation somatic mutation frequency in cancer cohorts.
Deepankar Chakroborty +5 more
doaj +1 more source
Protein–ligand binding affinity prediction with edge awareness and supervised attention
iScience, 2023 Summary: Accurate prediction of protein–ligand binding affinity is crucial in structure-based drug design but remains some challenges even with recent advances in deep learning: (1) Existing methods neglect the edge information in protein and ligand ...
Yuliang Gu +9 more
doaj +1 more source
Cancer Science, Volume 115, Issue 9, Page 2893-2907, September 2024.Our study successfully identified a specific signature for CAFs within prostate cancer (PCa). We established that CAFs are linked to PCa progression, higher Gleason scores, and CRPC. The significance of CAFs in PCa was further underscored by their maintenance of high signal output post‐ADT and the stable gene signature.
Shen Pan +5 more
wiley +1 more source
Engineered Bacteria as Living Biosensors in Dermal Tattoos
Advanced Science, Volume 11, Issue 30, August 14, 2024.Tattoo based biosensors are systems that use skin as a diagnostic interface for biomarker monitoring. In this article, engineered bacteria biosensors are interfaced into dermal tattoos through the embedding of bacteria into microgels generated through microfluidics.
Matthew E. Allen +6 more
wiley +1 more source
ACKR3 in olfactory glia cells shapes the immune defense of the olfactory mucosa
Glia, Volume 72, Issue 6, Page 1183-1200, June 2024.Main Points Olfactory sustentacular cells express the atypical chemokine receptor ACKR3. ACKR3 cKO increases the expression of immune defense genes in sustentacular cells and Bowman’s glands. ACKR3 cKO leads to leukocyte recruitment to the olfactory mucosa.
André Dietz, Katja Senf, Eva M. Neuhaus
wiley +1 more source
iScience, 2020 Summary: Tool use is a striking aspect of animal behavior, but it is hard to infer how the capacity for different types of tool use emerged across animal taxa.
Iain G. Johnston, Ellen C. Røyrvik
doaj +1 more source