Results 51 to 60 of about 768 (137)

Synaptic Function in Memristor Devices for Neuromorphic Circuit Applications

Advanced Electronic Materials, Volume 11, Issue 14, September 4, 2025.
Discover how neuromorphic devices mimic brain‐like learning: this article explores how ionic and electronic conduction processes enable artificial synapses to adapt across time scales. Uncover the essential ingredients—state‐variable dynamics, rectification, and memory—and how they can be probed through nonlinear diagnostics to engineer smarter, more ...
Juan Bisquert, Wooyoung Shim, So‐Yeon Kim, Bernabe Linares‐Barranco   +3 more
wiley   +1 more source

Modeling foot sole cutaneous afferents: FootSim

iScience, 2023
Summary: While walking and maintaining balance, humans rely on cutaneous feedback from the foot sole. Electrophysiological recordings reveal how this tactile feedback is represented in neural afferent populations, but obtaining them is difficult and ...
Natalija Katic, Rodrigo Kazu Siqueira, Luke Cleland, Nicholas Strzalkowski, Leah Bent, Stanisa Raspopovic, Hannes Saal   +6 more
doaj   +1 more source

Rapid Structural Characterization of Human Antibody-Antigen Complexes through Experimentally Validated Computational Docking

, 2010
If we understand the structural rules governing antibody (Ab)-antigen (Ag) interactions in a given virus, then we have the molecular basis to attempt to design and synthesize new epitopes to be used as vaccines or optimize the antibodies themselves for ...
CALZOLAI Luigi, VARANI Luca, BELTRAMELLO Martina, SIMONELLI L., YUDINA Zinaida, MACAGNO Annalisa   +5 more
core   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, Volume 15, Issue 8, Page 1192-1208, August 2025.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

The dynamics of prion spreading is governed by the interplay between the non-linearities of tissue response and replication kinetics

iScience
Summary: Prion diseases, or transmissible spongiform encephalopathies (TSEs), are neurodegenerative disorders caused by the accumulation of misfolded conformers (PrPSc) of the cellular prion protein (PrPC).
Basile Fornara, Angélique Igel, Vincent Béringue, Davy Martin, Pierre Sibille, Laurent Pujo-Menjouet, Human Rezaei   +6 more
doaj   +1 more source

A Kmer-based paired-end read de novo assembler and genotyper for canine MHC class I genotyping

iScience, 2023
Summary: The major histocompatibility complex class I (MHC-I) genes are highly polymorphic. MHC-I genotyping is required for determining the peptide epitopes available to an individual’s T-cell repertoire.
Yuan Feng, Paul R. Hess, Stephen M. Tompkins, William H. Hildebrand, Shaying Zhao   +4 more
doaj   +1 more source

Structural aspects of the Huntingtin protein investigated by biocomputing methods

, 2011
Huntington’s disease (HD) is a neurodegenerative disorder which leads to death within a couple of decades. It causes uncontrolled movements, loss of intellectual faculties and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in a specific gene, the HTT gene. This gene provides the genetic information for a
openaire   +2 more sources

Multistable Physical Neural Networks

Advanced Intelligent Systems, Volume 7, Issue 6, June 2025.
This article presents the integration of mechanical bistability into physical neural networks (PNNs), enabling memory retention and bridging computation with physical action. By mapping the equilibrium states of bistable, liquid‐filled chambers, it explores stability and introduces global and local training algorithms.
Ben‐Haim Eran, Givli Sefi, Or Yizhar, Gat D. Amir   +3 more
wiley   +1 more source

Using active learning methodologies to teach sequence analysis and molecular phylogeny

Biochemistry and Molecular Biology Education, Volume 53, Issue 1, Page 21-32, January/February 2025.
Abstract The great development of high‐throughput molecular biology techniques and the consequent generation of massive data have made Bioinformatics essential for undergraduate Bioscience students. The importance of this scientific discipline is evidenced by the huge number of specialized publications, tools, and databases available.
Inmaculada Ortiz Martín, Ángel Del Espino Pérez, Estefanía García Luque, Enrique Viguera Mínguez   +3 more
wiley   +1 more source

See the small lesions: Frequency-guided spatial debiasing GAN for multimodal medical image fusion

iScience
Summary: Multimodal medical image fusion uses these features from different modalities to generate fused images with richer information for diagnosis. However, in medical images, the lesion area only constitutes a small portion, and feature extraction is
Tao Zhou, Jiaqi Wang, Huiling Lu, Mingzhe Zhang, Zhe Zhang, Hongqiang Yu, Pengfei Zheng   +6 more
doaj   +1 more source