Results 51 to 60 of about 10,988,700 (173)
iScience, 2020 Summary: Molecular components that are functionally interdependent in human cells constitute molecular association networks. Disease can be caused by disturbance of multiple molecular interactions.
Hai-Cheng Yi +5 more
doaj +1 more source
iScience, 2023 Summary: Proposing a general segmentation approach for lung lesions, including pulmonary nodules, pneumonia, and tuberculosis, in CT images will improve efficiency in radiology.
Lu Wang +9 more
doaj +1 more source
Multistable Physical Neural Networks
Advanced Intelligent Systems, Volume 7, Issue 6, June 2025.This article presents the integration of mechanical bistability into physical neural networks (PNNs), enabling memory retention and bridging computation with physical action. By mapping the equilibrium states of bistable, liquid‐filled chambers, it explores stability and introduces global and local training algorithms.
Ben‐Haim Eran +3 more
wiley +1 more source
Ymir: A 3D structural affinity model for multi-epitope vaccine simulations
iScience, 2021 Summary: Vaccine development is challenged by the hierarchy of immunodominance between target antigen epitopes and the emergence of antigenic variants by pathogen mutation.
Philippe A. Robert +2 more
doaj +1 more source
Using active learning methodologies to teach sequence analysis and molecular phylogeny
Biochemistry and Molecular Biology Education, Volume 53, Issue 1, Page 21-32, January/February 2025.Abstract The great development of high‐throughput molecular biology techniques and the consequent generation of massive data have made Bioinformatics essential for undergraduate Bioscience students. The importance of this scientific discipline is evidenced by the huge number of specialized publications, tools, and databases available.
Inmaculada Ortiz Martín +3 more
wiley +1 more source
Molecular Nutrition &Food Research, Volume 68, Issue 24, December 2024.Human milk (HM) is a complex fluid rich in nutrients and bioactive compounds. This study analysed the HM metabolite profile of 123 healthy women and detected 432 different metabolites. These metabolites were clustered into three distinct groups, mainly driven by differences in triglyceride concentrations. C‐section, breastfeeding practices and maternal
Joaquim Calvo‐Lerma +7 more
wiley +1 more source
Protein–ligand binding affinity prediction with edge awareness and supervised attention
iScience, 2023 Summary: Accurate prediction of protein–ligand binding affinity is crucial in structure-based drug design but remains some challenges even with recent advances in deep learning: (1) Existing methods neglect the edge information in protein and ligand ...
Yuliang Gu +9 more
doaj +1 more source
Molecular Oncology, Volume 18, Issue 10, Page 2524-2540, October 2024.The machinery that carries out maturation of RNA, the spliceosome, is severely altered in pancreatic ductal adenocarcinoma. Decreased expression of two splicing factors, PRPF8 and RBMX, is linked to aggressiveness features and poor survival, while their rescue improves cell behavior.
Emilia Alors‐Pérez +19 more
wiley +1 more source
Cancer Science, Volume 115, Issue 9, Page 2893-2907, September 2024.Our study successfully identified a specific signature for CAFs within prostate cancer (PCa). We established that CAFs are linked to PCa progression, higher Gleason scores, and CRPC. The significance of CAFs in PCa was further underscored by their maintenance of high signal output post‐ADT and the stable gene signature.
Shen Pan +5 more
wiley +1 more source
Engineered Bacteria as Living Biosensors in Dermal Tattoos
Advanced Science, Volume 11, Issue 30, August 14, 2024.Tattoo based biosensors are systems that use skin as a diagnostic interface for biomarker monitoring. In this article, engineered bacteria biosensors are interfaced into dermal tattoos through the embedding of bacteria into microgels generated through microfluidics.
Matthew E. Allen +6 more
wiley +1 more source