Results 31 to 40 of about 768 (137)

Computational characterization of recombinase circuits for periodic behaviors

iScience, 2023
Summary: Recombinases are site-specific proteins found in nature that are capable of rearranging DNA. This function has made them promising gene editing tools in synthetic biology, as well as key elements in complex artificial gene circuits implementing ...
Judith Landau, Christian Cuba Samaniego, Giulia Giordano, Elisa Franco   +3 more
doaj   +1 more source

Identifying Transcription Factor Combinations to Modulate Circadian Rhythms by Leveraging Virtual Knockouts on Transcription Networks

iScience, 2020
Summary: The mammalian circadian systems consist of indigenous, self-sustained 24-h rhythm generators. They comprise many genes, molecules, and regulators. To decode their systematic controls, a robust computational approach was employed.
Debajyoti Chowdhury, Chao Wang, Aiping Lu, Hailong Zhu   +3 more
doaj   +1 more source

Estimation of Genome Size in the Endemic Species Reseda pentagyna and the Locally Rare Species Reseda lutea Using comparative Analyses of Flow Cytometry and K-Mer Approaches

, 2021
Genome size is one of the fundamental cytogenetic features of a species, which is critical for the design and initiation of any genome sequencing projects and can provide essential insights in studying taxonomy, cytogenetics, phylogenesis, and ...
Mohamed Tarroum, Naser B. Almarri, Norah S. Alfarraj, Fahad Al-Qurainy, Saleh Alansi, Abdel-Rhman Z. Gaafar, Aref M. Alshameri, Salim Khan, Mohammad Nadeem   +8 more
core   +1 more source

COOBoostR: An Extreme Gradient Boosting-Based Tool for Robust Tissue or Cell-of-Origin Prediction of Tumors

Life, 2022
We present here COOBoostR, a computational method designed for the putative prediction of the tissue- or cell-of-origin of various cancer types. COOBoostR leverages regional somatic mutation density information and chromatin mark features to be applied ...
Sungmin Yang, Kyungsik Ha, Woojeung Song, Masashi Fujita, Kirsten Kübler, Paz Polak, Eiso Hiyama, Hidewaki Nakagawa, Hong-Gee Kim, Hwajin Lee   +9 more
doaj   +1 more source

Measurement of eroded dentine tubule patency and roughness following novel dab-on or brushing abrasion [PDF]

, 2020
Objectives: To investigate the effect of dab-on or brushing of stannous-fluoride SnF2 or sodium-fluoride NaF dentifrice on eroded dentine tubule patency, surface and inter-tubular dentine roughness, using Confocal-Laser-Scanning-Microscopy (CLSM), Atomic-
Mohsen, Basim M., Alhaij, Sana, Appleton, Paul L., Olley, Ryan C.   +3 more
core   +1 more source

Smart DNA sensors‐based molecular identification for cancer subtyping

Smart Molecules, Volume 1, Issue 3, December 2023., 2023
Molecular subtyping of cancer is crucial for understanding the development of disease and predicting tumor behavior. This review focuses on the advanced strategies of molecular subtyping using DNA‐based biosensors for the identification of cancer subtypes based on different biomarkers, including cells, extracellular vesicles (EVs), and microRNAs ...
Yingying Gao, Mengyi Xiong, Chaonan Gong, Bo Wang, Longwei Bai, Xiao‐Bing Zhang   +5 more
wiley   +1 more source

MRI-based deep learning model predicts distant metastasis and chemotherapy benefit in stage II nasopharyngeal carcinoma

iScience, 2023
Summary: Chemotherapy remains controversial for stage II nasopharyngeal carcinoma because of its considerable prognostic heterogeneity. We aimed to develop an MRI-based deep learning model for predicting distant metastasis and assessing chemotherapy ...
Yu-Jun Hu, Lin Zhang, You-Ping Xiao, Tian-Zhu Lu, Qiao-Juan Guo, Shao-Jun Lin, Lan Liu, Yun-Bin Chen, Zi-Lu Huang, Ya Liu, Yong Su, Li-Zhi Liu, Xiao-Chang Gong, Jian-Ji Pan, Jin-Gao Li, Yun-Fei Xia   +15 more
doaj   +1 more source

Response of cancer to treatment by chemotherapy and electrochemical therapy using biocomputational modeling and simulation

, 2022
ilustraciones,Los modelos de electroporación y electroquimioterapia son esquemas teóricos que describen procesos electrofisiológicos basados en formulaciones matemáticas que ayudan a comprender y predecir el comportamiento de fenómenos de transporte y ...
Vélez Salazar, Fabián Mauricio
core   +1 more source

Inferring direction of associations between histone modifications using a neural processes-based framework

iScience, 2023
Summary: Current technologies do not allow predicting interactions between histone post-translational modifications (HPTMs) at a system-level. We describe a computational framework, imputation-followed-by-inference, to predict directed association ...
Ananthakrishnan Ganesan, Denis Dermadi, Laurynas Kalesinskas, Michele Donato, Rosalie Sowers, Paul J. Utz, Purvesh Khatri   +6 more
doaj   +1 more source

RetroSnake: A modular pipeline to detect human endogenous retroviruses in genome sequencing data

iScience, 2022
Summary: Human endogenous retroviruses (HERVs) integrated into the human genome as a result of ancient exogenous infections and currently comprise ∼8% of our genome.
Renata Kabiljo, Harry Bowles, Heather Marriott, Ashley R. Jones, Clement R. Bouton, Richard J.B. Dobson, John P. Quinn, Ahmad Al Khleifat, Chad M. Swanson, Ammar Al-Chalabi, Alfredo Iacoangeli   +10 more
doaj   +1 more source