Results 11 to 20 of about 768 (137)

Pan-genomic matching statistics for targeted nanopore sequencing

iScience, 2021
Summary: Nanopore sequencing is an increasingly powerful tool for genomics. Recently, computational advances have allowed nanopores to sequence in a targeted fashion; as the sequencer emits data, software can analyze the data in real time and signal the ...
Omar Ahmed, Massimiliano Rossi, Sam Kovaka, Michael C. Schatz, Travis Gagie, Christina Boucher, Ben Langmead   +6 more
doaj   +3 more sources

The role of antigen expression in shaping the repertoire of HLA presented ligands

iScience, 2022
Summary: Human leukocyte antigen (HLA) presentation of peptides is a prerequisite of T cell immune activation. The understanding of the rules defining this event has large implications for our knowledge of basic immunology and for the rational design of ...
Heli M. Garcia Alvarez, Zeynep Koşaloğlu-Yalçın, Bjoern Peters, Morten Nielsen   +3 more
doaj   +3 more sources

Reinforcement learning in densely recurrent biological networks [PDF]

iScience
Summary: Training highly recurrent networks is a technical challenge: gradient-based methods suffer from exploding or vanishing gradients, while purely evolutionary searches converge slowly.
Miles Walter Churchland, Jordi Garcia-Ojalvo   +1 more
doaj   +2 more sources

An efficient framework for protein-protein interaction prediction by integrating stacked denoising autoencoders and random ferns [PDF]

iScience
Summary: Protein-protein interactions (PPIs) are crucial for understanding disease and discovering drug targets. To overcome the limitations of experimental methods, we propose SDAERFs, a computational framework that predicts PPIs from protein sequences.
Zheng Wang, Lei Wang, Yang Li, Zhu-Hong You, Yue-Chao Li   +4 more
doaj   +2 more sources

Endodermal cells use contact inhibition of locomotion to achieve uniform cell dispersal during zebrafish gastrulation [PDF]

iScience
Summary: The endoderm is one of the three primary germ layers that gives rise to the gastrointestinal and respiratory epithelia and other tissues. Prior to epithelium formation, endodermal cells are highly migratory with only transient interactions among
Jesselynn LaBelle, Tom Wyatt, Jaxson Ramirez, Stephanie Woo   +3 more
doaj   +2 more sources

Mixed Selectivity in Macaque Medial Parietal Cortex during Eye-Hand Reaching

iScience, 2020
Summary: The activity of neurons of the medial posterior parietal area V6A in macaque monkeys is modulated by many aspects of reach task. In the past, research was mostly focused on modulating the effect of single parameters upon the activity of V6A ...
Stefano Diomedi, Francesco E. Vaccari, Matteo Filippini, Patrizia Fattori, Claudio Galletti   +4 more
doaj   +3 more sources

Deep learning-enabled high-performance multiphoton fluorescence vascular imaging using clinically approved fluorescent probes [PDF]

iScience
Summary: Among various modalities, multiphoton fluorescence imaging (MPFI) stands out for its exceptionally high spatial resolution in deep tissue imaging.
Zhourui Xu, Haoran Luo, Ting Chen, Shoulong Yang, Junkang Peng, Yibin Zhang, Yi Gao, Yonghong Shao, Wing-Cheung Law, Ken-Tye Yong, Ke Wang, Gaixia Xu   +11 more
doaj   +2 more sources

Learning Representations to Predict Intermolecular Interactions on Large-Scale Heterogeneous Molecular Association Network

iScience, 2020
Summary: Molecular components that are functionally interdependent in human cells constitute molecular association networks. Disease can be caused by disturbance of multiple molecular interactions.
Hai-Cheng Yi, Zhu-Hong You, De-Shuang Huang, Zhen-Hao Guo, Keith C.C. Chan, Yangming Li   +5 more
doaj   +3 more sources

A single-cell and tissue-scale analysis suite resolves Mixl1’s role in heart development [PDF]

iScience
Summary: Perturbation studies using gene knockouts have become a key tool for understanding the roles of regulatory genes in development. However, large-scale studies dissecting the molecular role of development master regulators in every cell type ...
Magdalena E. Strauss, Mai-Linh Nu Ton, Samantha Mason, Jaana Bagri, Luke T.G. Harland, Ivan Imaz-Rosshandler, Nicola K. Wilson, Jennifer Nichols, Richard C.V. Tyser, Berthold Göttgens, John C. Marioni, Carolina Guibentif   +11 more
doaj   +2 more sources

A general approach for automatic segmentation of pneumonia, pulmonary nodule, and tuberculosis in CT images

iScience, 2023
Summary: Proposing a general segmentation approach for lung lesions, including pulmonary nodules, pneumonia, and tuberculosis, in CT images will improve efficiency in radiology.
Lu Wang, He Zhou, Nan Xu, Yuchan Liu, Xiran Jiang, Shu Li, Chaolu Feng, Hainan Xu, Kexue Deng, Jiangdian Song   +9 more
doaj   +3 more sources