Results 21 to 30 of about 768 (137)
Efficient trace reconstruction in DNA storage systems using bidirectional beam search [PDF]
iScienceSummary: As DNA data storage gains popularity, efficient trace reconstruction algorithms are crucial for fast decoding of data from noisy sequenced reads (or “traces”).
Zhenhao Gu +5 more
doaj +2 more sources
dotears: Scalable and consistent directed acyclic graph estimation using observational and interventional data [PDF]
iScienceSummary: New assays such as Perturb-seq link parallel CRISPR interventions to transcriptomic readouts, providing insight into gene regulatory networks.
Albert Xue +3 more
doaj +2 more sources
Exploitation of Biocomputational Approaches for siRNA-Mediated Gene Silencing of HPV: A Novel Therapeutic Strategy for Cervical Cancer. [PDF]
Cancer Rep (Hoboken)ABSTRACT Background With recurrent high‐risk human papillomavirus (HPV) infections, especially HPV16 and HPV18, cervical cancer is the fourth most common disease among women. The functional alterations of the E6 and E7 proteins are essential to the oncogenic process of high‐risk HPVs and cervical cancer development.
Masum MHU +4 more
europepmc +2 more sources
Low-Input Assay for Transposase-Accessible Chromatin Identifies Epigenetic Signatures of Liver Group 1 Innate Lymphoid Cells. [PDF]
Eur J ImmunolAssessing chromatin accessibility in rare cell populations within tissue remains a key challenge. To address this, we present a low‐input ATAC workflow optimized for liver ILCs. The protocol is validated across cell numbers, Tn5 ratios, and library preparation steps and unveils unique epigenetic features of liver NK cells and ILC1s.
Schmid K, Schenk RP, Wiedemann GM.
europepmc +2 more sources
iScience, 2023 Summary: The hippocampus plays a vital role in navigation, learning, and memory, and is affected in Alzheimer’s disease (AD). This study investigated the classification of AD-transgenic rats versus wild-type littermates using electrophysiological ...
Faraz Moradi +6 more
doaj +1 more source
iScience, 2021 Summary: In terms of genome and particle sizes, viruses exhibit great diversity. With the discovery of several nucleocytoplasmic large DNA viruses (NCLDVs) and jumbo phages, the relationship between particle and genome sizes has emerged as an important ...
Harshali V. Chaudhari +2 more
doaj +1 more source
2D effects enhance precision of gradient-based tissue patterning
iScience, 2023 Summary: Robust embryonic development requires pattern formation with high spatial accuracy. In epithelial tissues that are patterned by morphogen gradients, the emerging patterns achieve levels of precision that have recently been explained by a simple ...
Yuchong Long, Roman Vetter, Dagmar Iber
doaj +1 more source
The computational rules of cross-modality suppression in the visual posterior sylvian area
iScience, 2023 Summary: The macaque visual posterior sylvian area (VPS) is an area with neurons responding selectively to heading direction in both visual and vestibular modalities, but how VPS neurons combined these two sensory signals is still unknown. In contrast to
Bin Zhao +4 more
doaj +1 more source
Predicting Human Clinical Outcomes Using Mouse Multi-Organ Transcriptome
iScience, 2020 Summary: Approximately 90% of pre-clinically validated drugs fail in clinical trials owing to unanticipated clinical outcomes, costing over several hundred million US dollars per drug.
Satoshi Kozawa +5 more
doaj +1 more source
iScience, 2022 Summary: Single-cell transcriptomics enables the definition of diverse human immune cell types across multiple tissues and disease contexts. Further deeper biological understanding requires comprehensive integration of multiple single-cell omics ...
Congmin Xu +5 more
doaj +1 more source