Results 21 to 30 of about 10,988,700 (173)

A geometric framework for understanding dynamic information integration in context-dependent computation

iScience, 2021
Summary: The prefrontal cortex (PFC) plays a prominent role in performing flexible cognitive functions and working memory, yet the underlying computational principle remains poorly understood.
Xiaohan Zhang, Shenquan Liu, Zhe Sage Chen   +2 more
doaj   +1 more source

Inferring Disease-Associated MicroRNAs Using Semi-supervised Multi-Label Graph Convolutional Networks

iScience, 2019
Summary: MicroRNAs (miRNAs) play crucial roles in biological processes involved in diseases. The associations between diseases and protein-coding genes (PCGs) have been well investigated, and miRNAs interact with PCGs to trigger them to be functional. We
Xiaoyong Pan, Hong-Bin Shen
doaj   +1 more source

ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response

iScience, 2020
Summary: The unfolded protein response (UPR) pathway senses unfolded proteins and regulates proteostasis and cell fate through activity of the transcription factors ATF4, ATF6, and XBP1 within a complex network of three main branches.
Huan Yang, Marije Niemeijer, Bob van de Water, Joost B. Beltman   +3 more
doaj   +1 more source

MRI-based deep learning model predicts distant metastasis and chemotherapy benefit in stage II nasopharyngeal carcinoma

iScience, 2023
Summary: Chemotherapy remains controversial for stage II nasopharyngeal carcinoma because of its considerable prognostic heterogeneity. We aimed to develop an MRI-based deep learning model for predicting distant metastasis and assessing chemotherapy ...
Yu-Jun Hu, Lin Zhang, You-Ping Xiao, Tian-Zhu Lu, Qiao-Juan Guo, Shao-Jun Lin, Lan Liu, Yun-Bin Chen, Zi-Lu Huang, Ya Liu, Yong Su, Li-Zhi Liu, Xiao-Chang Gong, Jian-Ji Pan, Jin-Gao Li, Yun-Fei Xia   +15 more
doaj   +1 more source

Pan-genomic matching statistics for targeted nanopore sequencing

iScience, 2021
Summary: Nanopore sequencing is an increasingly powerful tool for genomics. Recently, computational advances have allowed nanopores to sequence in a targeted fashion; as the sequencer emits data, software can analyze the data in real time and signal the ...
Omar Ahmed, Massimiliano Rossi, Sam Kovaka, Michael C. Schatz, Travis Gagie, Christina Boucher, Ben Langmead   +6 more
doaj   +1 more source

Insect-Inspired Sequential Inspection Strategy Enables an Artificial Network of Four Neurons to Estimate Numerosity

iScience, 2019
Summary: Varying levels of numerical cognition have been found in several animal species. Bees, in particular, have been argued to be able to count up to four items and solve complex numerical tasks.
Vera Vasas, Lars Chittka
doaj   +1 more source

Inferring direction of associations between histone modifications using a neural processes-based framework

iScience, 2023
Summary: Current technologies do not allow predicting interactions between histone post-translational modifications (HPTMs) at a system-level. We describe a computational framework, imputation-followed-by-inference, to predict directed association ...
Ananthakrishnan Ganesan, Denis Dermadi, Laurynas Kalesinskas, Michele Donato, Rosalie Sowers, Paul J. Utz, Purvesh Khatri   +6 more
doaj   +1 more source

RetroSnake: A modular pipeline to detect human endogenous retroviruses in genome sequencing data

iScience, 2022
Summary: Human endogenous retroviruses (HERVs) integrated into the human genome as a result of ancient exogenous infections and currently comprise ∼8% of our genome.
Renata Kabiljo, Harry Bowles, Heather Marriott, Ashley R. Jones, Clement R. Bouton, Richard J.B. Dobson, John P. Quinn, Ahmad Al Khleifat, Chad M. Swanson, Ammar Al-Chalabi, Alfredo Iacoangeli   +10 more
doaj   +1 more source

COOBoostR: An Extreme Gradient Boosting-Based Tool for Robust Tissue or Cell-of-Origin Prediction of Tumors

Life, 2022
We present here COOBoostR, a computational method designed for the putative prediction of the tissue- or cell-of-origin of various cancer types. COOBoostR leverages regional somatic mutation density information and chromatin mark features to be applied ...
Sungmin Yang, Kyungsik Ha, Woojeung Song, Masashi Fujita, Kirsten Kübler, Paz Polak, Eiso Hiyama, Hidewaki Nakagawa, Hong-Gee Kim, Hwajin Lee   +9 more
doaj   +1 more source

The role of antigen expression in shaping the repertoire of HLA presented ligands

iScience, 2022
Summary: Human leukocyte antigen (HLA) presentation of peptides is a prerequisite of T cell immune activation. The understanding of the rules defining this event has large implications for our knowledge of basic immunology and for the rational design of ...
Heli M. Garcia Alvarez, Zeynep Koşaloğlu-Yalçın, Bjoern Peters, Morten Nielsen   +3 more
doaj   +1 more source