Inferring Disease-Associated MicroRNAs Using Semi-supervised Multi-Label Graph Convolutional Networks [PDF]
iScience, 2019 Summary: MicroRNAs (miRNAs) play crucial roles in biological processes involved in diseases. The associations between diseases and protein-coding genes (PCGs) have been well investigated, and miRNAs interact with PCGs to trigger them to be functional. We
Xiaoyong Pan, Hong-Bin Shen
doaj +2 more sources
The journey towards clinical adoption of MALDI-MS-based imaging proteomics: from current challenges to future expectations [PDF]
FEBS Letters, Volume 598, Issue 6, Page 621-634, March 2024., 2023 Among the spatial omics techniques available, mass spectrometry imaging (MSI) represents one of the most promising owing to its capability to map the distribution of hundreds of peptides and proteins, as well as other classes of biomolecules, within a ...
Magni F, Smith A., Piga I
core +2 more sources
iScience, 2019 Summary: Varying levels of numerical cognition have been found in several animal species. Bees, in particular, have been argued to be able to count up to four items and solve complex numerical tasks.
Vera Vasas, Lars Chittka
doaj +2 more sources
iScience, 2021 Summary: The identification of proteins at the single-molecule level would open exciting new venues in biological research and disease diagnostics.
Carlos de Lannoy +3 more
doaj +3 more sources
Evaluation of the Anticancer Properties of Lamellar Alkaloid Drivatives Extracted from the Tunicate <i>Didemnum abradatum</i> (Moucha Island Sea, Djibouti): Pharmacological and Computational Approach. [PDF]
MoleculesThis study aimed to evaluate the anticancer activity of lamellar alkaloid derivatives extracted from the tunicate Didemnum abradatum from Moucha Island (Djibouti), focusing on their antiviability against human cell lines and using biocomputational ...
Abdoul-Latif FM +7 more
europepmc +2 more sources
GCCVision: An integrated toolkit for calculating and visualizing parental genome contribution in breeding populations [PDF]
iScienceSummary: Tracking parental genome contributions in segregating populations is crucial for accelerating genetic gain in plant breeding. We introduce GCCVision (Genome Contribution Calculator and Visualizer), an integrated bioinformatics toolkit to ...
Enhui Shen +4 more
doaj +2 more sources
ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response
iScience, 2020 Summary: The unfolded protein response (UPR) pathway senses unfolded proteins and regulates proteostasis and cell fate through activity of the transcription factors ATF4, ATF6, and XBP1 within a complex network of three main branches.
Huan Yang +3 more
doaj +3 more sources
Neural network-assisted RNA velocity imputation for empowering transcript dynamics-based analyses [PDF]
iScienceSummary: Existing RNA velocity estimation tools often fail to calculate velocities for a substantial portion of genes due to technical limitations or model assumptions, thereby restricting downstream analyses that rely on velocity estimations.
Riku Egami +4 more
doaj +2 more sources
iScience, 2021 Summary: The prefrontal cortex (PFC) plays a prominent role in performing flexible cognitive functions and working memory, yet the underlying computational principle remains poorly understood.
Xiaohan Zhang +2 more
doaj +3 more sources
iScience, 2019 Summary: Long non-coding RNA (lncRNA) play critical roles in the occurrence and development of various diseases. The determination of the lncRNA-disease associations thus would contribute to provide new insights into the pathogenesis of the disease, the ...
Zhen-Hao Guo +4 more
doaj +3 more sources