Results 41 to 50 of about 10,988,700 (173)

Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation

iScience
Summary: Toxicogenomic data provide key insights into molecular mechanisms underlying drug-induced organ toxicities. To simplify transcriptomic data interpretation, we applied weighted gene co-expression network analysis (WGCNA) to rat kidney ...
Steven J. Kunnen, Giulia Callegaro, Jeffrey J. Sutherland, Panuwat Trairatphisan, Hugo W. van Kessel, Lukas S. Wijaya, Git Chung, Keith Pye, Keith M. Goldstein, Claire R. Teague, Ciaran P. Fisher, Julio Saez-Rodriguez, Colin Brown, Susan A. Elmore, Kathleen M. Heinz-Taheny, James L. Stevens, Bob van de Water   +16 more
doaj   +1 more source

Robust deep learning model for prognostic stratification of pancreatic ductal adenocarcinoma patients

iScience, 2021
Summary: A major challenge for treating patients with pancreatic ductal adenocarcinoma (PDAC) is the unpredictability of their prognoses due to high heterogeneity.
Jie Ju, Leonoor V. Wismans, Dana A.M. Mustafa, Marcel J.T. Reinders, Casper H.J. van Eijck, Andrew P. Stubbs, Yunlei Li   +6 more
doaj   +1 more source

Electroactive Proteinoid–Quantum Dot Systems

Small Science, Volume 5, Issue 12, December 2025.
Proteinoid‐quantum dot conjugates form toroidal nanostructures (145.2 nm outer diameter, 102.3 nm cavity) via glutamic acid‐phenylalanine‐aspartic acid‐cysteine cross‐linking with sulfo‐SMCC (sulfosuccinimidyl 4‐(N‐maleimidomethyl)cyclohexane‐1‐carboxylate).
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source

Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma

iScience, 2022
Summary: Microenvironment cells (MCs) play a critical role in tumor proliferation, progression, and metastasis. However, it has not been adequately addressed whether MCs could be used as a reliable prognostic marker in glioblastoma (GBM).
Hao Zhang, Nan Zhang, Wantao Wu, Zeyu Wang, Ziyu Dai, Xisong Liang, Liyang Zhang, Yun Peng, Peng Luo, Jian Zhang, Zaoqu Liu, Quan Cheng, Zhixiong Liu   +12 more
doaj   +1 more source

The dynamics of prion spreading is governed by the interplay between the non-linearities of tissue response and replication kinetics

iScience
Summary: Prion diseases, or transmissible spongiform encephalopathies (TSEs), are neurodegenerative disorders caused by the accumulation of misfolded conformers (PrPSc) of the cellular prion protein (PrPC).
Basile Fornara, Angélique Igel, Vincent Béringue, Davy Martin, Pierre Sibille, Laurent Pujo-Menjouet, Human Rezaei   +6 more
doaj   +1 more source

Modeling foot sole cutaneous afferents: FootSim

iScience, 2023
Summary: While walking and maintaining balance, humans rely on cutaneous feedback from the foot sole. Electrophysiological recordings reveal how this tactile feedback is represented in neural afferent populations, but obtaining them is difficult and ...
Natalija Katic, Rodrigo Kazu Siqueira, Luke Cleland, Nicholas Strzalkowski, Leah Bent, Stanisa Raspopovic, Hannes Saal   +6 more
doaj   +1 more source

Synaptic Function in Memristor Devices for Neuromorphic Circuit Applications

Advanced Electronic Materials, Volume 11, Issue 14, September 4, 2025.
Discover how neuromorphic devices mimic brain‐like learning: this article explores how ionic and electronic conduction processes enable artificial synapses to adapt across time scales. Uncover the essential ingredients—state‐variable dynamics, rectification, and memory—and how they can be probed through nonlinear diagnostics to engineer smarter, more ...
Juan Bisquert, Wooyoung Shim, So‐Yeon Kim, Bernabe Linares‐Barranco   +3 more
wiley   +1 more source

A Kmer-based paired-end read de novo assembler and genotyper for canine MHC class I genotyping

iScience, 2023
Summary: The major histocompatibility complex class I (MHC-I) genes are highly polymorphic. MHC-I genotyping is required for determining the peptide epitopes available to an individual’s T-cell repertoire.
Yuan Feng, Paul R. Hess, Stephen M. Tompkins, William H. Hildebrand, Shaying Zhao   +4 more
doaj   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, Volume 15, Issue 8, Page 1192-1208, August 2025.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Structural aspects of the Huntingtin protein investigated by biocomputing methods

, 2011
Huntington’s disease (HD) is a neurodegenerative disorder which leads to death within a couple of decades. It causes uncontrolled movements, loss of intellectual faculties and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in a specific gene, the HTT gene. This gene provides the genetic information for a
openaire   +2 more sources