Results 41 to 50 of about 768 (137)

SCING: Inference of robust, interpretable gene regulatory networks from single cell and spatial transcriptomics

iScience, 2023
Summary: Gene regulatory network (GRN) inference is an integral part of understanding physiology and disease. Single cell/nuclei RNA-seq (scRNA-seq/snRNA-seq) data has been used to elucidate cell-type GRNs; however, the accuracy and speed of current ...
Russell Littman, Michael Cheng, Ning Wang, Chao Peng, Xia Yang   +4 more
doaj   +1 more source

Quantifying the impact of physical activity on future glucose trends using machine learning

iScience, 2022
Summary: Prevention of hypoglycemia (glucose
Nichole S. Tyler, Clara Mosquera-Lopez, Gavin M. Young, Joseph El Youssef, Jessica R. Castle, Peter G. Jacobs   +5 more
doaj   +1 more source

miRSCAPE - inferring miRNA expression from scRNA-seq data

iScience, 2022
Summary: Our understanding of miRNA activity at cellular resolution is thwarted by the inability of standard scRNA-seq protocols to capture miRNAs. We introduce a novel tool, miRSCAPE, to infer miRNA expression in a sample from its RNA-seq profile.
Gulden Olgun, Vishaka Gopalan, Sridhar Hannenhalli   +2 more
doaj   +1 more source

Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation

iScience
Summary: Toxicogenomic data provide key insights into molecular mechanisms underlying drug-induced organ toxicities. To simplify transcriptomic data interpretation, we applied weighted gene co-expression network analysis (WGCNA) to rat kidney ...
Steven J. Kunnen, Giulia Callegaro, Jeffrey J. Sutherland, Panuwat Trairatphisan, Hugo W. van Kessel, Lukas S. Wijaya, Git Chung, Keith Pye, Keith M. Goldstein, Claire R. Teague, Ciaran P. Fisher, Julio Saez-Rodriguez, Colin Brown, Susan A. Elmore, Kathleen M. Heinz-Taheny, James L. Stevens, Bob van de Water   +16 more
doaj   +1 more source

Robust deep learning model for prognostic stratification of pancreatic ductal adenocarcinoma patients

iScience, 2021
Summary: A major challenge for treating patients with pancreatic ductal adenocarcinoma (PDAC) is the unpredictability of their prognoses due to high heterogeneity.
Jie Ju, Leonoor V. Wismans, Dana A.M. Mustafa, Marcel J.T. Reinders, Casper H.J. van Eijck, Andrew P. Stubbs, Yunlei Li   +6 more
doaj   +1 more source

Electroactive Proteinoid–Quantum Dot Systems

Small Science, Volume 5, Issue 12, December 2025.
Proteinoid‐quantum dot conjugates form toroidal nanostructures (145.2 nm outer diameter, 102.3 nm cavity) via glutamic acid‐phenylalanine‐aspartic acid‐cysteine cross‐linking with sulfo‐SMCC (sulfosuccinimidyl 4‐(N‐maleimidomethyl)cyclohexane‐1‐carboxylate).
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source

KRAS Ubiquitination at Lysine 104 Retains Exchange Factor Regulation by Dynamically Modulating the Conformation of the Interface

iScience, 2020
Summary: RAS proteins function as highly regulated molecular switches that control cellular growth. In addition to regulatory proteins, RAS undergoes a number of posttranslational modifications (PTMs) that regulate its activity.
Guowei Yin, Jerry Zhang, Vinay Nair, Vinh Truong, Angelo Chaia, Johnny Petela, Joseph Harrison, Alemayehu A. Gorfe, Sharon L. Campbell   +8 more
doaj   +1 more source

Technology for biocomputational devices based on molecular motors [PDF]

, 2019
For many multivariable problems there are no efficient algorithms for finding solutions. To this day, conventional electronic computers mainly solve problems in a sequential manner.
Lindberg, Frida
core  

A Semiautomated Structure-Based Method To Predict Substrates of Enzymes via Molecular Docking: A Case Study with Candida antarctica Lipase B

, 2016
The discovery of unique substrates is important for developing potential applications of enzymes. However, the experimental procedures for substrate identification are laborious, time-consuming, and expensive.
Zhiqiang Yao (3136368), Lujia Zhang (790750), Bei Gao (59773), John Z. H. Zhang (477768), Xiao He (223527), Dongzhi Wei (59777), Dongbing Cui (3136371), Fengqing Wang (191668)   +7 more
core   +1 more source

Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma

iScience, 2022
Summary: Microenvironment cells (MCs) play a critical role in tumor proliferation, progression, and metastasis. However, it has not been adequately addressed whether MCs could be used as a reliable prognostic marker in glioblastoma (GBM).
Hao Zhang, Nan Zhang, Wantao Wu, Zeyu Wang, Ziyu Dai, Xisong Liang, Liyang Zhang, Yun Peng, Peng Luo, Jian Zhang, Zaoqu Liu, Quan Cheng, Zhixiong Liu   +12 more
doaj   +1 more source