Results 81 to 90 of about 9,513 (205)
Computational and Structural Biotechnology JournalAlphaFold2 predicts protein structures from structural and functional knowledge. Alternatively, ESMFold does the same adopting protein language models. Here, we map available Pfam domains on pairs of models of the human reference proteome computed with ...
Matteo Manfredi +4 more
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Germline contamination and leakage in whole genome somatic single nucleotide variant detection
BMC Bioinformatics, 2018 Background The clinical sequencing of cancer genomes to personalize therapy is becoming routine across the world. However, concerns over patient re-identification from these data lead to questions about how tightly access should be controlled.
Dorota H. Sendorek +10 more
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Biocomputing 2017:Proceedings of the Pacific Symposium
, 2017 The Pacific Symposium on Biocomputing (PSB) 2017 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance ...
Russ B Altman +5 more
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"Going back to our roots": second generation biocomputing
, 2006 Researchers in the field of biocomputing have, for many years, successfully used the natural world as inspiration for developing systems that are robust, adaptable and capable of generating novel and even "creative" solutions to human-defined problems ...
Timmis, Jon +3 more
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International, interdisziplinär und interaaktiv: Der VSNS-Kurs über BioComputing
, 1997 Fuellen G, Giegerich R. International, interdisziplinär und interaaktiv: Der VSNS-Kurs über BioComputing. In: Proceedings: Virtueller Campus.
Fuellen, Georg, Giegerich, Robert
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Nature CommunicationsEngineering multicellular consortia, where information processing is distributed across specialized cell types, offers a promising strategy for implementing sophisticated biocomputing systems. However, a major challenge remains in establishing orthogonal
Hadiastri Kusumawardhani +3 more
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Pathway-based subnetworks enable cross-disease biomarker discovery
Nature Communications, 2018 Accurate and actionable biomarkers that integrate diverse molecular, functional and clinical information hold great promise in precision medicine. Here, the authors develop SIMMS, a method for pathway-based cross-disease biomarker discovery.
Syed Haider +24 more
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Criticality in Biocomputation.
, 2017 Complexity in biological computation is one of the recognised means by which biological systems manage to function in a complex chaotic world. The ability to function and solve problems irrespective of scale and relative complexity, including higher-order interactions, is essential to the efficacy of biological systems. However, it has been unclear how
openaire +2 more sources
CoCoNat: A Deep Learning–Based Tool for the Prediction of Coiled-coil Domains in Protein Sequences
Bio-ProtocolCoiled-coil domains (CCDs) are structural motifs observed in proteins in all organisms that perform several crucial functions. The computational identification of CCD segments over a protein sequence is of great importance for its functional ...
Matteo Manfredi +3 more
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Evaluation of the structural models of the human reference proteome: AlphaFold2 versus ESMFold
Current Research in Structural BiologyThe human reference proteome is routinely modelled with predictive tools such as AlphaFold2. We recently released a database in which, for each human protein, the AlphaFold2 model is paired with its ESMFold counterpart.
Matteo Manfredi +3 more
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