Results 61 to 70 of about 7,742 (179)

SemiSynBio: A new era for neuromorphic computing

Synthetic and Systems Biotechnology
Neuromorphic computing has the potential to achieve the requirements of the next-generation artificial intelligence (AI) systems, due to its advantages of adaptive learning and parallel computing. Meanwhile, biocomputing has seen ongoing development with
Ruicun Liu, Tuoyu Liu, Wuge Liu, Boyu Luo, Yuchen Li, Xinyue Fan, Xianchao Zhang, Wei Cui, Yue Teng   +8 more
doaj   +1 more source

Measuring local-directional resolution and local anisotropy in cryo-EM maps

Nature Communications, 2020
It is important to analyse the local resolution of cryo-EM maps. Here the authors present MonoDir, a fully automatic and parameter free method for the directional local resolution analysis of cryo-EM maps that requires only the final map as input and ...
Jose Luis Vilas, Hemant D. Tagare, Javier Vargas, Jose Maria Carazo, Carlos Oscar S. Sorzano   +4 more
doaj   +1 more source

AlphaFold2 and ESMFold: A large-scale pairwise model comparison of human enzymes upon Pfam functional annotation

Computational and Structural Biotechnology Journal
AlphaFold2 predicts protein structures from structural and functional knowledge. Alternatively, ESMFold does the same adopting protein language models. Here, we map available Pfam domains on pairs of models of the human reference proteome computed with ...
Matteo Manfredi, Gabriele Vazzana, Castrense Savojardo, Pier Luigi Martelli, Rita Casadio   +4 more
doaj   +1 more source

Germline contamination and leakage in whole genome somatic single nucleotide variant detection

BMC Bioinformatics, 2018
Background The clinical sequencing of cancer genomes to personalize therapy is becoming routine across the world. However, concerns over patient re-identification from these data lead to questions about how tightly access should be controlled.
Dorota H. Sendorek, Cristian Caloian, Kyle Ellrott, J. Christopher Bare, Takafumi N. Yamaguchi, Adam D. Ewing, Kathleen E. Houlahan, Thea C. Norman, Adam A. Margolin, Joshua M. Stuart, Paul C. Boutros   +10 more
doaj   +1 more source

Biomanufacturing and Scale‐Up: Pathways to Biochemicals, Biofuels, and Biomaterials

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
Carolina A. Barcelos, Pavel Dvořák, Charles J. Foster, Juan Nogales, Juan L. Ramos, Shamlan M. S. Reshamwala, Davinia Salvachúa   +6 more
wiley   +1 more source

Pathways to cellular supremacy in biocomputing

Nature Communications, 2019
Synthetic biology uses cells as its computing substrate, often based on the genetic circuit concept. In this Perspective, the authors argue that existing synthetic biology approaches based on classical models of computation limit the potential of ...
Lewis Grozinger, Martyn Amos, Thomas E. Gorochowski, Pablo Carbonell, Diego A. Oyarzún, Ruud Stoof, Harold Fellermann, Paolo Zuliani, Huseyin Tas, Angel Goñi-Moreno   +9 more
doaj   +1 more source

Pathway-based subnetworks enable cross-disease biomarker discovery

Nature Communications, 2018
Accurate and actionable biomarkers that integrate diverse molecular, functional and clinical information hold great promise in precision medicine. Here, the authors develop SIMMS, a method for pathway-based cross-disease biomarker discovery.
Syed Haider, Cindy Q. Yao, Vicky S. Sabine, Michal Grzadkowski, Vincent Stimper, Maud H. W. Starmans, Jianxin Wang, Francis Nguyen, Nathalie C. Moon, Xihui Lin, Camilla Drake, Cheryl A. Crozier, Cassandra L. Brookes, Cornelis J. H. van de Velde, Annette Hasenburg, Dirk G. Kieback, Christos J. Markopoulos, Luc Y. Dirix, Caroline Seynaeve, Daniel W. Rea, Arek Kasprzyk, Philippe Lambin, Pietro Lio’, John M. S. Bartlett, Paul C. Boutros   +24 more
doaj   +1 more source

Criticality in Biocomputation.

, 2017
Complexity in biological computation is one of the recognised means by which biological systems manage to function in a complex chaotic world. The ability to function and solve problems irrespective of scale and relative complexity, including higher-order interactions, is essential to the efficacy of biological systems. However, it has been unclear how
openaire   +2 more sources

Engineering intercellular communication using M13 phagemid and CRISPR-based gene regulation for multicellular computing in Escherichia coli

Nature Communications
Engineering multicellular consortia, where information processing is distributed across specialized cell types, offers a promising strategy for implementing sophisticated biocomputing systems. However, a major challenge remains in establishing orthogonal
Hadiastri Kusumawardhani, Florian Zoppi, Roberto Avendaño, Yolanda Schaerli   +3 more
doaj   +1 more source

CoCoNat: A Deep Learning–Based Tool for the Prediction of Coiled-coil Domains in Protein Sequences

Bio-Protocol
Coiled-coil domains (CCDs) are structural motifs observed in proteins in all organisms that perform several crucial functions. The computational identification of CCD segments over a protein sequence is of great importance for its functional ...
Matteo Manfredi, Castrense Savojardo, Pier Luigi Martelli, Rita Casadio   +3 more
doaj   +1 more source