Results 41 to 50 of about 9,513 (205)

SeqBMC: Single‐cell data processing using iterative block matrix completion algorithm based on matrix factorisation

IET Systems Biology
With the development of high‐throughput sequencing technology, the analysis of single‐cell RNA sequencing data has become the focus of current research.
Gong Lejun, Yu Like, Wei Xinyi, Zhou Shehai, Xu Shuhua   +4 more
doaj   +1 more source

Open and remotely accessible Neuroplatform for research in wetware computing

Frontiers in Artificial Intelligence
Wetware computing and organoid intelligence is an emerging research field at the intersection of electrophysiology and artificial intelligence. The core concept involves using living neurons to perform computations, similar to how Artificial Neural ...
Fred D. Jordan, Martin Kutter, Jean-Marc Comby, Flora Brozzi, Ewelina Kurtys   +4 more
doaj   +1 more source

Cryo‐EM structure of GH43 β‐Xylosidase from Enterobacter cloacae provides insights into substrate specificity and the role of an auxiliary domain in enzymatic activity

The FEBS Journal, EarlyView.
Xylan, the second most abundant plant cell wall polysaccharide, is degraded by β‐xylanases and β‐xylosidases. Here, we present the 2.65 Å cryo‐EM structure of Enterobacter cloacae β‐xylosidase (EcXyl43, GH43) and the 2.4 Å X‐ray structure of its inactive F507A mutant.
Lorenzo Briganti, Andre Schutzer Godoy, Caio Cesar Mello Capetti, Rafaela Sachetto Fernandes, Vanessa O. A. Pellegrini, Ornella M. Ontañon, Eleonora Campos, Rodrigo V. Portugal, Igor Polikarpov   +8 more
wiley   +1 more source

iGATTLDA: Integrative graph attention and transformer‐based model for predicting lncRNA‐Disease associations

IET Systems Biology
Long non‐coding RNAs (lncRNAs) have emerged as significant contributors to the regulation of various biological processes, and their dysregulation has been linked to a variety of human disorders.
Biffon Manyura Momanyi, Sebu Aboma Temesgen, Tian‐Yu Wang, Hui Gao, Ru Gao, Hua Tang, Li‐Xia Tang   +6 more
doaj   +1 more source

Large-scale prediction and analysis of protein sub-mitochondrial localization with DeepMito

BMC Bioinformatics, 2020
Background The prediction of protein subcellular localization is a key step of the big effort towards protein functional annotation. Many computational methods exist to identify high-level protein subcellular compartments such as nucleus, cytoplasm or ...
Castrense Savojardo, Pier Luigi Martelli, Giacomo Tartari, Rita Casadio   +3 more
doaj   +1 more source

Quantitative insights into the spatio‐temporal variation of Atlantic salmon (Salmo salar) biomass in a river catchment using eDNA metabarcoding

Journal of Fish Biology, EarlyView.
Abstract Effective species conservation and management requires comprehensive biomonitoring, enhanced by combining traditional and newer methodologies, such as environmental DNA (eDNA) analyses. A seasonal pulse of spawning adult Atlantic salmon (Salmo salar) was detected by normalised eDNA 12S reads from metabarcoding, which facilitated estimation of ...
William Bernard Perry, Nigel Milner, Ifan Bryn Jâms, Mark de Bruyn, Steve J. Ormerod, Kristy Deiner, Holly M. Bik, Gary Carvalho, John Colbourne, Bernard Jack Cosby, Isabelle Durance, Simon Creer   +11 more
wiley   +1 more source

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

Molecular Microbiology, EarlyView.
During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol, Dominik Šťastný, J. Pedro Fernandez‐Murray, Christopher R. McMaster, Peter Griač, Dave Richard   +5 more
wiley   +1 more source

Probing the molecular determinants of emission enhancement in RNA aptamer–metal complex systems

Photochemistry and Photobiology, EarlyView.
Light up aptamer: fluorophore pairs are widely used in sensing and imaging, with coordination complex fluorophores providing specific benefits due to their long‐lived emission. Here, we examined key structural and electronic features of these metal complexes to identify the requirements for productive engagement with an RNA aptamer.
Sarah M. Kriger, Joseph Spiconardi, Nathan Ennist, Edith C. Glazer   +3 more
wiley   +1 more source

UWB-Biocomputing/GraphSystemsAnalysis: Horrible Horrible Hippo

, 2022
This is being released only to generate a DOI on Zenodo.
Dev Mathur, Emily Hsu, Smriti Singh, Michael Stiber   +3 more
core   +1 more source

Red‐to‐Near‐Infrared Fluorescence Resonance Energy Transfer Reporters for Dual Imaging Applications

Small Methods, Volume 10, Issue 15, 7 August 2026.
Genetically encoded FRET biosensors reveal dynamic signaling in living cells, but overlapping spectra have limited the simultaneous monitoring of multiple pathways. We introduce a red‐to‐near infrared FRET pair, mRuby2/miRFP670nano3, compatible with existing reporters and enabling dual FLIM‐FRET without bleed‐through.
Van Thi‐Hong Tran, Frans Ek, Hasan Yassine, Rajalaxmi Behera, Vesa P. Hytönen, James R. W. Conway   +5 more
wiley   +1 more source