Results 41 to 50 of about 7,742 (179)

Characterization and Crystal Structure Elucidation of the l‐Homoserine O‐Succinyltransferase MetXS From Cupriavidus necator H16

ChemBioChem, Volume 27, Issue 20, 28 October 2026.
This study reports the identification, heterologous production, and in vitro characterization of the homoserine O‐succinyltransferase from C. necator (CnMetXS). Several biochemical parameters, including the pH and temperature optima, thermostability, substrate scope, and kinetic parameters, are determined, and a high‐resolution X‐ray structure of ...
Hannah Pia Franziska Meier, Rick Oerlemans, Henrik Terholsen, Matthew R. Groves, Lars Lauterbach, Sandy Schmidt   +5 more
wiley   +1 more source

Engineering a protein homodimer from a heterodimer: A chimeric DBHS protein

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Drosophila behavior/human splicing (DBHS) proteins are involved at nearly every stage of the RNA lifecycle. There are three paralogues in mammals—SFPQ, NONO and PSPC1—which form both homodimer and heterodimers. It is likely that the non‐redundant and overlapping roles of the different DBHS paralogues emerge from their dynamic and combinatorial
Andrew C. Marshall, Isabelle Mohnen, Alejandro Villa Gomez, Archa H. Fox, Gavin J. Knott, Charles S. Bond   +5 more
wiley   +1 more source

FSC-Q: a CryoEM map-to-atomic model quality validation based on the local Fourier shell correlation

Nature Communications, 2021
Here, the authors present a cryo-EM validation method for the local analysis of the map-to-model fit and introduce FSC-Q as a quality measure. FSC-Q provides a quantitative estimation of how much of the model is supported by the signal content of the map.
Erney Ramírez-Aportela, David Maluenda, Yunior C. Fonseca, Pablo Conesa, Roberto Marabini, J. Bernard Heymann, Jose Maria Carazo, Carlos Oscar S. Sorzano   +7 more
doaj   +1 more source

Co‐phylogeny and biogeography of the myrmecophilous beetle Paussus favieri (Carabidae, Paussinae) and its host ant Pheidole pallidula (Hymenoptera, Myrmicinae)

Insect Science, Volume 33, Issue 5, Page 2210-2226, October 2026.
Strict patterns of co‐divergence have rarely been documented other than among organisms and their symbionts. In this paper, using a molecular approach, we inferr the population‐level phylogenies of a Mediterranean ant species Pheidole pallidula and its nest parasite, the obligate myrmecophilous beetle Paussus favieri. We then investigate the role of co‐
Davide Bergamaschi, Wendy Moore, Andrea Di Giulio   +2 more
wiley   +1 more source

Mechanism of action of “cistanche deserticola–Polygala” in treating Alzheimer's disease based on network pharmacology methods and molecular docking analysis

IET Systems Biology
This article used network pharmacology, molecular docking, GEO analysis, and Gene Set Enrichment Analysis to obtain 38 main chemical components and 66 corresponding targets involved in Alzheimer's disease (AD) treatment in "Cistanche deserticola‐Polygala"
Shaoqiang Wang, Yifan Wang
doaj   +1 more source

SENSIBLE: SEquestered aNd SynergIstic BLockchain Ecosystem

Engineering Reports, 2023
Health care interoperability unfolds the way for personalized health care services at a reduced cost. Furthermore, a decentralized system holds the promise to prevent compromises such as cyber‐attacks due to data breaches.
Meghana Kshirsagar, Gauri Vaidya, Yao Yao, Smita Kasar, Conor Ryan   +4 more
doaj   +1 more source

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

Molecular Microbiology, Volume 126, Issue 4, Page 412-432, October 2026.
During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol, Dominik Šťastný, J. Pedro Fernandez‐Murray, Christopher R. McMaster, Peter Griač, Dave Richard   +5 more
wiley   +1 more source

General Artificial Intelligence needs Consciousness

Studium: Filosofía y Teología
Human-like, Artificial General Intelligence (AGI) must autonomously explore reality, set its own goals, and demonstrate genuine creativity, such as making original scientific discoveries. Creativity in humans is rooted in high-level consciousness and the
George Zarkadakis
doaj   +1 more source

Mechanistic Understanding of Protein–MOF Integration Through Surfactant‐Driven Interfacial Design

Advanced Science, Volume 13, Issue 52, 18 September 2026.
This study reveals how surfactant‐driven interfacial design governs the assembly and stability of protein@MOF composites. Using lipid‐based nonionic surfactants, we modulate protein–MOF interactions to improve encapsulation efficiency, MOF crystallization, and catalytic performance.
Ehsan Rashidniyaghi, Mohammad Khavani, Carlie Coerver, Ruibin Liang, Raheleh Ravanfar   +4 more
wiley   +1 more source

Optimization and expansion of non-negative matrix factorization

BMC Bioinformatics, 2020
Background Non-negative matrix factorization (NMF) is a technique widely used in various fields, including artificial intelligence (AI), signal processing and bioinformatics.
Xihui Lin, Paul C. Boutros
doaj   +1 more source