Results 31 to 40 of about 2,499 (218)

Diverse Taxonomies for Diverse Chemistries: Enhanced Representation of Natural Product Metabolism in UniProtKB

open access: yesMetabolites, 2021
The UniProt Knowledgebase UniProtKB is a comprehensive, high-quality, and freely accessible resource of protein sequences and functional annotation that covers genomes and proteomes from tens of thousands of taxa, including a broad range of plants and ...
Marc Feuermann   +18 more
doaj   +1 more source

RCSB Protein Data bank: Tools for visualizing and understanding biological macromolecules in 3D

open access: yesProtein Science, Volume 31, Issue 12, December 2022., 2022
Abstract Now in its 52nd year of continuous operations, the Protein Data Bank (PDB) is the premiere open‐access global archive housing three‐dimensional (3D) biomolecular structure data. It is jointly managed by the Worldwide Protein Data Bank (wwPDB) partnership.
Stephen K. Burley   +40 more
wiley   +1 more source

Biocuration Virtual Issue 2012 [PDF]

open access: yesDatabase, 2012
Curated databases are a cornerstone of research in the life sciences providing essential encyclopedic-like reference information on genes, their products and interactions, nomenclature standards, reference genome sequences and their annotations. Research laboratories and experimental techniques rely on resources such as databases and bioinformatics ...
Gaudet, Pascale, Mazumder, Raja
openaire   +2 more sources

Exploring Manually Curated Annotations of Intrinsically Disordered Proteins with DisProt

open access: yesCurrent Protocols, Volume 2, Issue 7, July 2022., 2022
Abstract DisProt is the major repository of manually curated data for intrinsically disordered proteins collected from the literature. Although lacking a stable three‐dimensional structure under physiological conditions, intrinsically disordered proteins carry out a plethora of biological functions, some of them directly arising from their flexible ...
Federica Quaglia   +4 more
wiley   +1 more source

ECO-CollecTF: A Corpus of Annotated Evidence-Based Assertions in Biomedical Manuscripts

open access: yesFrontiers in Research Metrics and Analytics, 2021
Analysis of high-throughput experiments in the life sciences frequently relies upon standardized information about genes, gene products, and other biological entities.
Elizabeth T. Hobbs   +14 more
doaj   +1 more source

SARS‐CoV‐2 variants preferentially emerge at intrinsically disordered protein sites helping immune evasion

open access: yesThe FEBS Journal, Volume 289, Issue 14, Page 4240-4250, July 2022., 2022
Intrinsically disordered regions (IDRs) are abundant in the SARS‐CoV‐2 spike glycoprotein S1 subunit and nucleoprotein. Mutations occurring in the 13 main variants, including Omicron, correlate with these IDRs and play a role in immune evasion. Moreover, IDRs in the major antigenic site of the spike glycoprotein suggest a role of intrinsic disorder in ...
Federica Quaglia   +5 more
wiley   +1 more source

GOing Forward With the Cardiac Conduction System Using Gene Ontology

open access: yesFrontiers in Genetics, 2022
The cardiac conduction system (CCS) comprises critical components responsible for the initiation, propagation, and coordination of the action potential. Aberrant CCS development can cause conduction abnormalities, including sick sinus syndrome, accessory
Kan Yan Chloe Li   +3 more
doaj   +1 more source

Plasma proteins, cognitive decline, and 20‐year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies

open access: yesAlzheimer's &Dementia, Volume 18, Issue 4, Page 612-624, April 2022., 2022
Abstract Introduction Plasma proteins affect biological processes and are common drug targets but their role in the development of Alzheimer's disease and related dementias remains unclear. We examined associations between 4953 plasma proteins and cognitive decline and risk of dementia in two cohort studies with 20‐year follow‐ups.
Joni V. Lindbohm   +14 more
wiley   +1 more source

John D. Westbrook Jr (1957–2021)

open access: yesActa Crystallographica Section D, Volume 77, Issue 11, Page 1475-1476, November 2021., 2021
John Westbrook is remembered.John Westbrook is remembered.
Christine Zardecki, Stephen K. Burley
wiley   +1 more source

An Evidence‐Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine

open access: yesClinical Pharmacology &Therapeutics, Volume 110, Issue 3, Page 563-572, September 2021., 2021
Clinical annotations are one of the most popular resources available on the Pharmacogenomics Knowledgebase (PharmGKB). Each clinical annotation summarizes the association between variant‐drug pairs, shows relevant findings from the curated literature, and is assigned a level of evidence (LOE) to indicate the strength of support for that association ...
Michelle Whirl‐Carrillo   +6 more
wiley   +1 more source

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