Results 31 to 40 of about 2,499 (218)
The UniProt Knowledgebase UniProtKB is a comprehensive, high-quality, and freely accessible resource of protein sequences and functional annotation that covers genomes and proteomes from tens of thousands of taxa, including a broad range of plants and ...
Marc Feuermann +18 more
doaj +1 more source
RCSB Protein Data bank: Tools for visualizing and understanding biological macromolecules in 3D
Abstract Now in its 52nd year of continuous operations, the Protein Data Bank (PDB) is the premiere open‐access global archive housing three‐dimensional (3D) biomolecular structure data. It is jointly managed by the Worldwide Protein Data Bank (wwPDB) partnership.
Stephen K. Burley +40 more
wiley +1 more source
Biocuration Virtual Issue 2012 [PDF]
Curated databases are a cornerstone of research in the life sciences providing essential encyclopedic-like reference information on genes, their products and interactions, nomenclature standards, reference genome sequences and their annotations. Research laboratories and experimental techniques rely on resources such as databases and bioinformatics ...
Gaudet, Pascale, Mazumder, Raja
openaire +2 more sources
Exploring Manually Curated Annotations of Intrinsically Disordered Proteins with DisProt
Abstract DisProt is the major repository of manually curated data for intrinsically disordered proteins collected from the literature. Although lacking a stable three‐dimensional structure under physiological conditions, intrinsically disordered proteins carry out a plethora of biological functions, some of them directly arising from their flexible ...
Federica Quaglia +4 more
wiley +1 more source
ECO-CollecTF: A Corpus of Annotated Evidence-Based Assertions in Biomedical Manuscripts
Analysis of high-throughput experiments in the life sciences frequently relies upon standardized information about genes, gene products, and other biological entities.
Elizabeth T. Hobbs +14 more
doaj +1 more source
Intrinsically disordered regions (IDRs) are abundant in the SARS‐CoV‐2 spike glycoprotein S1 subunit and nucleoprotein. Mutations occurring in the 13 main variants, including Omicron, correlate with these IDRs and play a role in immune evasion. Moreover, IDRs in the major antigenic site of the spike glycoprotein suggest a role of intrinsic disorder in ...
Federica Quaglia +5 more
wiley +1 more source
GOing Forward With the Cardiac Conduction System Using Gene Ontology
The cardiac conduction system (CCS) comprises critical components responsible for the initiation, propagation, and coordination of the action potential. Aberrant CCS development can cause conduction abnormalities, including sick sinus syndrome, accessory
Kan Yan Chloe Li +3 more
doaj +1 more source
Abstract Introduction Plasma proteins affect biological processes and are common drug targets but their role in the development of Alzheimer's disease and related dementias remains unclear. We examined associations between 4953 plasma proteins and cognitive decline and risk of dementia in two cohort studies with 20‐year follow‐ups.
Joni V. Lindbohm +14 more
wiley +1 more source
John D. Westbrook Jr (1957–2021)
John Westbrook is remembered.John Westbrook is remembered.
Christine Zardecki, Stephen K. Burley
wiley +1 more source
An Evidence‐Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine
Clinical annotations are one of the most popular resources available on the Pharmacogenomics Knowledgebase (PharmGKB). Each clinical annotation summarizes the association between variant‐drug pairs, shows relevant findings from the curated literature, and is assigned a level of evidence (LOE) to indicate the strength of support for that association ...
Michelle Whirl‐Carrillo +6 more
wiley +1 more source

