Results 191 to 200 of about 63,325 (247)

Non-invasive visualization of pH changes within the tumor-micro-environment by positron emission tomography. [PDF]

EJNMMI Res
Brück J, Schauenburg D, Kuan SL, Göttert S, Klasen B, Frommberger V, Jalal KE, Boui N, Kwiatkowski A, Schake L, Bopp T, Bohn T, Weil T, Schreckenberger M, Miederer M.   +14 more
europepmc   +1 more source

Neutrophil‐Mimetic Nanoscavengers Target the Inflammatory Microenvironment to Eliminate NETs/ROS and Immunomodulate cGAS‐STING Signaling in Septic AKI

Advanced Science, EarlyView.
Sepsis‐associated acute kidney injury is driven by oxidative stress, NETs overproduction, and dysregulated innate immunity. Here, we develop neutrophil‐mimetic nanoscavengers that integrate ROS‐scavenging Mn3O4 nanozymes with DNase‐1‐mediated NETs degradation to suppress cGAS‐STING signaling, reprogram macrophage polarization, and effectively alleviate
Zening Zhang, Chenxi Zhang, Ranran Luo, Qiuchi Wu, Pengchen Ren, Xinyu Liu, Yingying Luo, Zhongsheng Xu, Xiaojing He, Yun Liu   +9 more
wiley   +1 more source

Central Nervous System Biodistribution and Pharmacokinetics of Radiolabeled Tofersen in Rodents, Nonhuman Primates, and Humans. [PDF]

J Nucl Med
Cook BE, McLaren DG, Sullivan JM, El Fakhri G, Yokell DL, Freeman MW, Currier N, Oestergaard ME, Dobson H, Hesterman J, Salem N, Nestorov I, Monine M, Martarello L, Evans KC, Fradette S, Ferguson TA, Graham D, Passamonti L.   +18 more
europepmc   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Biodistribution of the Bombesin Receptor-Targeted Radiopharmaceutical Precursor BBN/C1-C2 in a Prostate Cancer Model. [PDF]

Sovrem Tekhnologii Med
Beloborodov EA, Iurova EV, Dolgova DR, Ermakova AA, Sugak DE, Fomin AN, Saenko YV.   +6 more
europepmc   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Quantitative Assessment of Particulate Matter Biodistribution Using ¹⁴C-Nanotracing and Accelerator Mass Spectrometry. [PDF]

Environ Sci Technol
Song S, Lee GH, Oh MS, Lim S, Kim YK, Kim Y, Yu BY.   +6 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Modified tumor uptake and biodistribution of nanoparticles coated with small extracellular vesicle membranes derived from distinct tumor cell lines. [PDF]

Int J Hyperthermia
Jenkins SV, Carlton H, Scott B, Stahr SD, Vinson W, Fletcher G, Jamshidi-Parsian A, Hsu PC, Dings RPM, Huitink D, Griffin RJ.   +10 more
europepmc   +1 more source