Results 171 to 180 of about 85,054 (209)

Bioavailability and biodistribution of nanodelivered lutein

Food Chemistry, 2016
The aim of the study was to evaluate the ability of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NP) to enhance lutein bioavailability. The bioavailability of free lutein and PLGA-NP lutein in rats was assessed by determining plasma pharmacokinetics and deposition in selected tissues. Lutein uptake and secretion was also assessed in Caco-2 cells.
Alison, Kamil, Donald E, Smith, Jeffrey B, Blumberg, Carlos, Astete, Cristina, Sabliov, C-Y, Oliver Chen   +5 more
openaire   +2 more sources

Scintigraphic visualization of intrathecal liposome biodistribution [PDF]

Acta Anaesthesiologica Scandinavica, 1997
Background: Liposomes containing local anaesthetics have been administered intrathecally and in the epidural space. Poor attention has been given to the pharmacokinetics of liposomes as drug carriers. Therefore, we observed the biodistribution of liposomes after intrathecal injection in rats by scintigraphic imaging during 24 h.Methods: We administered
Umbrain, V, D'Haese, J, Alafandy, M, De Roover, E, Schoutens, A, Van Gansbeke, B, Albert, Adelin, Goffinet, Gerhard, Camu, F, Legros, F J   +9 more
openaire   +4 more sources

Biodistribution of phosphodiester and phosphorothioate siRNA

Bioorganic & Medicinal Chemistry Letters, 2004
Short interfering RNAs (siRNAs) are valuable tools for analyzing protein function in mammalian cell culture. This success has led to high expectations for in vivo and therapeutic applications. However, the pharmacokinetic properties of siRNA are not known.
Dwaine A, Braasch, Zain, Paroo, Anca, Constantinescu, Gang, Ren, Orhan K, Oz, Ralph P, Mason, David R, Corey   +6 more
openaire   +2 more sources

In VivoBiodistribution of Nanoparticles

Nanomedicine, 2011
Nanoparticles have potential applications in diagnostics, imaging, gene and drug delivery and other types of therapy. Iron oxide nanoparticles, gold nanoparticles and quantum dots have all generated substantial interest and their properties and applications have been thoroughly studied. Yet, metal-containing particles raise biodistribution and toxicity
Joao Paulo Mattos, Almeida, Allen L, Chen, Aaron, Foster, Rebekah, Drezek   +3 more
openaire   +2 more sources

Biodistribution and toxicity of gold nanoparticles

Nanotechnologies in Russia, 2011
This paper reviews data on the biodistribution and toxicity of five types of gold nanoparticles (GNPs) (atomic clusters and colloidal particles with diameters of 1 to 200 nm, gold nanorods (GNRs), silica/gold nanoshells (GNSs), hollow GNSs, and nanowires) in in vivo and in vitro experiments.
Lev Dykman, Nikolai Khlebtsov
openaire   +1 more source

Biodistribution and Shedding of AAV Vectors

2011
Determining the AAV vector biodistribution and shedding is central for the safety assessment of proposed early-phase clinical trials. It is especially crucial in the case of AAV vectors since they are injected directly in situ with no possibility of an intermediate ex vivo step, such as in retroviral-mediated approaches.
Caroline, Le Guiner, Phillipe, Moullier, Valder R, Arruda   +2 more
openaire   +2 more sources

Radioiodinated cyclosporin A: Preparation and biodistribution

The International Journal of Applied Radiation and Isotopes, 1980
Abstract A simple rapid procedure, using chloramine T, has been developed for labelling Cyclosporin A with 123 I or 125 I. The labelling yield exceeds 95% and the radioiodinated product is not decomposed after sterilization by autoclaving. Biodistribution studies in rats show that the radioiodinated Cyclosporin A is rapidly taken up by the liver ...
openaire   +2 more sources

The Biodistribution of Radiocopper-Labeled Compounds

1989
Porphyrins form extremely stable chelates with Cu2+. Two copper radionuclides, 67Cu and 64Cu, have attractive nuclear decay properties for use in nuclear medicine applications. We have investigated the use of radiocopper-labeled porphyrins for localization in inflamed tissue and for attachment to antibodies for tumor imaging and therapy.
J A, Mercer-Smith, D A, Cole, J C, Roberts, D, Lewis, M J, Behr, D K, Lavallee   +5 more
openaire   +2 more sources

Biodistribution and Pharmacokinetics of Antimicrobials

2017
Inadequate drug concentrations in target tissues can lead to treatment failure and/or selection of drug-resistant organisms. Additionally, altered pharmacokinetics in diseased patients may elevate tissue drug levels leading to organ toxicity or failure.
Alvaro A. Ordonez, Lauren E. Bambarger, Sanjay K. Jain, Edward A. Weinstein   +3 more
openaire   +1 more source

Biodistribution of extracellular vesicles following administration into animals: A systematic review

Journal of Extracellular Vesicles, 2021
Matthew Kang, Vanessa Jordan, Cherie Blenkiron   +2 more
exaly