Results 191 to 200 of about 119,908 (286)

Immunotheranostics in Solid Tumors: Longitudinal Tracking of Human IL13Rα2 CAR-T Cells In Vivo. [PDF]

J Nucl Med
Mirzaei HR, Lovibond S, Gajecki L, Qureshy S, Kumpf M, Jeanjean P, Lee SG, Cai W, Miranda I, Mauguen A, Carter LM, Schöder H, Veach DR, Scheinberg DA, Krebs S.   +14 more
europepmc   +1 more source

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source

Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials. [PDF]

J Nucl Med
Mortensen ACL, Mohajershojai T, Gustafsson A, Berglund H, Selvaraju RK, Hofström C, Persson H, Ohlin M, Tran TA, Morén AF, Ochniewicz P, Zedenius J, Bernhardt P, Frejd FY, Nestor M.   +14 more
europepmc   +1 more source

Tracking of [14C]Polystyrene Nanoplastics in Pregnant Mice

Advanced Science, EarlyView.
This study investigates [14C]polystyrene nanoplastic ([14C]PS) translocation in late‐stage pregnant mice after intranasal (0.5 mg of [14C]PS on GD12, GD14, and GD16, n = 6) and intravenous administration (1.5 mg of [14C]PS on GD16, n = 6). 14C‐radiolabel allows quantitative tracking of unmodified polystyrene nanoplastics.
Olga Khaybullina, Pallavi Sarkhel, Outi M. Keinänen   +2 more
wiley   +1 more source

Prenatal Intraportal Delivery of Polymeric Nanoparticles to Fetal Rhesus Monkeys (<i>Macaca mulatta</i>). [PDF]

Hum Gene Ther
Piotrowski-Daspit AS, Lynn AY, Eaton DA, Bracaglia LG, Markey AI, Mortlock RD, Stitelman DH, Martinez ML, Lee CC, Kliman HJ, Glazer PM, Tarantal AF, Saltzman WM.   +12 more
europepmc   +1 more source

Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy

Advanced Science, EarlyView.
This study constructed the W1/O/W2 emulsion–based targeted therapy delivery system for ulcerative colitis (UC) utilizing LCC as surfactant for the first time. This multifunctional emulsion offered certain therapeutic advantages for UC, including targeted colonic delivery of active compounds, synergistic modulation of gut microbiota through combined ...
Qian Wu, Xingyu Zhang, Jingjia Zhang, Gaohui Huang, Chen Zhou, Chunlin Li, Xiaojun Huang, Jianbo Xiao, Nianjie Feng, Yuanbin She   +9 more
wiley   +1 more source

Detection of inflammation-related blood-brain barrier dysfunction using PET and MR imaging: a pilot study. [PDF]

Sci Rep
Hilbrig CF, Baumann B, Sievert W, Halbgebauer R, Huber-Lang M, Beer AJ, Rasche V, Löffler J.   +7 more
europepmc   +1 more source

Liver‐Targeted Gallium‐Polyphenol Network by Disrupting the ROS/NETs/PANoptosis Axis for Precision Acute Liver Injury Therapy

Advanced Science, EarlyView.
ABSTRACT Acute liver injury (ALI), driven by diverse insults such as drug toxicity and ischemia‐reperfusion, poses a high mortality risk and lacks targeted therapies. While reactive oxygen species (ROS), neutrophil extracellular traps (NETs), and a coordinated cell death pathway PANoptosis have been implicated, their interplay as a unified pathogenic ...
Xiaopeng Cai, Jian He, Jingwen Deng, Ziwei Wang, Zhongshu Wu, Kaiyue Wang, Xiang Zheng, Zhenzhen Gao, Xi Ma, Shumei Wei, Xiangrong Hu, Yuan Ding, Weilin Wang, Min Zhou   +13 more
wiley   +1 more source

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

Synthesis, Radiochemical Characterization, and Biodistribution of a ¹⁸⁸Re Analogue of [¹³¹I]mIBG in a Neuroblastoma Xenograft Model. [PDF]

J Labelled Comp Radiopharm
Sakhare N, Kumar D, Das S, Mitra A, Mirapurkar S, Rani G, Sheela M, Chirayil V, Mohanty B, Mathur A, Mallia MB, Chaudhari P.   +11 more
europepmc   +1 more source