Results 161 to 170 of about 85,054 (209)
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Allergen Biodistribution in Humans
2003Specific immunotherapy performed by noninjectable (oral, nasal or oromucosal) routes was mostly developed in the last 20 years with the main aim to avoid side effects that occasionally occur in the course of injectable immunotherapy. Although evidence of its clinical efficacy has been provided some pharmacokinetics aspects are still to be elucidated ...
Bagnasco, Marcello +5 more
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Biodistribution of 59Fe-thiosemicarbazones
International Journal of Nuclear Medicine and Biology, 1982The 59Fe-iron(II) chelates of 2-formylpyridine thiosemicarbazone (I), 5-dimethylamino-2-formylpyridine thiosemicarbazone (II), and 5-hydroxy-2-formylpyridine thiosemicarbazone (III) were prepared and their biodistribution determined in normal rats. Early accumulation of these complexes occurred in the liver, muscle and pelt with lesser amounts in the ...
R N, Hanson, M A, Davis
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Assessments of antibody biodistribution
The Journal of Clinical Pharmacology, 2015AbstractMonoclonal antibody (mAb) therapeutics are in use for several disease conditions, and have generally shown excellent clinical benefit, in large part due to their high specificity and affinity for target proteins. As this therapeutic class continues to grow in size, improved understanding of the mechanisms controlling mAb biodistribution and ...
Patrick M, Glassman +2 more
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Altered Biodistribution of 68Ga-DOTATOC
Clinical Nuclear Medicine, 2020Abstract 68Ga-DOTATOC PET/CT of a patient with metastatic neuroendocrine tumor reveals an abnormal biodistribution of the tracer with a vascular binding and a very low fixation on the known lesions despite the temporary discontinuation of “cold” somatostatin analogs.
Anne-Claire, Dupont +4 more
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Biodistribution of nanoparticles: Initial considerations
Journal of Pharmaceutical and Biomedical Analysis, 2012Nanotechnology is attracting increasing attention worldwide. This study was made use of modern technology to decipher most of the intriguing biological aspects of nanoparticles. Labeling with technetium-99m ((99m)Tc) of six nanoparticles using different compositions and formulations, as well as complete biodistribution studies in mice was done.
Lucas Torres Miranda, Sa +7 more
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Bioconjugation and biodistribution
2002The term “bioconjugation ” usually defines the specific covalent linking between two biomolecules, in order to obtain a novel molecular entity with peculiar physicochemi-cal and biological properties (1). In medicine, bioconjugation is mainly exploited to impart biological specificity to drugs or diagnostics.
VERONESE F.M., CALICETI, PAOLO
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Biodistribution of Radiolabeled Ethanol in Rodents
Drug Metabolism and Disposition, 2008The biodistribution of [1-(14)C]ethanol in rodents was examined to determine sites of concentration of ethanol or its metabolites that may contribute to its toxicological and pharmacokinetic characteristics. After i.v. administration of [1-(14)C]ethanol in mice, radioactivity showed a widespread distribution among body organs.
Andrew N, Gifford +2 more
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Biodistribution of pH-sensitive immunoliposomes
Biochimica et Biophysica Acta (BBA) - General Subjects, 1986Liposomes composed of either dioleoylphosphatidylethanolamine and oleic acid (pH-sensitive) or dioleoylphosphatidylcholine and oleic acid (pH-insensitive) were injected into C3H and Balb/c mice in order to determine the tissue distribution of both the lipid and the aqueous content.
J, Connor, N, Norley, L, Huang
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Iatrogenic alterations in radionuclide biodistributions
Seminars in Nuclear Medicine, 1979The biodistribution of radiotracers used in diagnostic imaging is grossly and recognizably altered by a wide variety of drugs and other treatment modalities, such as surgery and radiotherapy. Knowledge of such altered biodistribution is important both in making diagnostic inferences from scans and in dosimetric considerations.
B C, Lentle +3 more
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Radiolabeling and biodistribution of amiodarone and desethylamiodarone
Nuclear Medicine and Biology, 1995The antiarrhythmic drug amiodarone and its metabolite desethylamiodarone, were radiolabeled with sodium [123I]-iodide in > 98% yield using the exchange labeling method. Biodistribution studies with 123I-amiodarone in mice showed high liver and lung uptake.
J C, Bellen, S, Penglis, C, Tsopelas
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