Results 201 to 210 of about 125,907 (238)

Synthesis and Preclinical Development of a Novel ⁶⁸ Ga/ ⁸⁹ Zr-Labelled ανβ6-Integrin Targeting Trimer

Gariglio G, Patiño Álvarez FA, Zierke MA, Stangl S, Rheinfrank T, Holzleitner N, Kossatz S, Decristoforo C.   +7 more
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The biodistribution of metaiodobenzylguanidine

Seminars in Nuclear Medicine, 1992
M E T A I O D O B E N Z Y L G U A N I D I N E can be (MIBG) labeled with iodine-(123I) or 1311. The nearly ideal emission properties m a k e 1231 the preferred radionuclide? MIBG is a guanethidine analogue and was originally studied as a potential antihypertensive agent.
M T, Parisi, E D, Sandler, R S, Hattner
openaire   +2 more sources

Altered Biodistribution of 68Ga-DOTATOC

Clinical Nuclear Medicine, 2020
Abstract 68Ga-DOTATOC PET/CT of a patient with metastatic neuroendocrine tumor reveals an abnormal biodistribution of the tracer with a vascular binding and a very low fixation on the known lesions despite the temporary discontinuation of “cold” somatostatin analogs.
Anne-Claire, Dupont, Fanny, Borrelly, Thierry, Lecomte, Serge, Maia, Maria-Joao, Santiago Ribeiro   +4 more
openaire   +2 more sources

Biodistribution of 59Fe-thiosemicarbazones

International Journal of Nuclear Medicine and Biology, 1982
The 59Fe-iron(II) chelates of 2-formylpyridine thiosemicarbazone (I), 5-dimethylamino-2-formylpyridine thiosemicarbazone (II), and 5-hydroxy-2-formylpyridine thiosemicarbazone (III) were prepared and their biodistribution determined in normal rats. Early accumulation of these complexes occurred in the liver, muscle and pelt with lesser amounts in the ...
R N, Hanson, M A, Davis
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Assessments of antibody biodistribution

The Journal of Clinical Pharmacology, 2015
AbstractMonoclonal antibody (mAb) therapeutics are in use for several disease conditions, and have generally shown excellent clinical benefit, in large part due to their high specificity and affinity for target proteins. As this therapeutic class continues to grow in size, improved understanding of the mechanisms controlling mAb biodistribution and ...
Patrick M, Glassman, Lubna, Abuqayyas, Joseph P, Balthasar   +2 more
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Biodistribution of photosensitizing agents

International Journal of Biochemistry, 1993
1. The features of neoplasia which predict for drug responsiveness are rapid growth and/or inefficient repair of damage, especially to DNA. 2. PDT has the advantage of yielding responses regardless of the growth fraction of a tumor, and repair appears to play only a minor role. 3. While an entirely different spectrum of tumors can be targeted with PDT,
D, Kessel, K, Woodburn
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Allergen Biodistribution in Humans

2003
Specific immunotherapy performed by noninjectable (oral, nasal or oromucosal) routes was mostly developed in the last 20 years with the main aim to avoid side effects that occasionally occur in the course of injectable immunotherapy. Although evidence of its clinical efficacy has been provided some pharmacokinetics aspects are still to be elucidated ...
Bagnasco, Marcello, Morbelli, Silvia, Altrinetti, Vania, Falagiani, Paolo, Mariani, Giuliano, Passalacqua, Giovanni   +5 more
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Pharmacokinetics and Biodistribution of Nanoparticles

Molecular Pharmaceutics, 2008
Nanoparticles show their promise for improving the efficacy of drugs with a narrow therapeutic window or low bioavailability, such as anticancer drugs and nucleic acid-based drugs. The pharmacokinetics (PK) and tissue distribution of the nanoparticles largely define their therapeutic effect and toxicity.
Shyh-Dar, Li, Leaf, Huang
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Biodistribution of nanoparticles: Initial considerations

Journal of Pharmaceutical and Biomedical Analysis, 2012
Nanotechnology is attracting increasing attention worldwide. This study was made use of modern technology to decipher most of the intriguing biological aspects of nanoparticles. Labeling with technetium-99m ((99m)Tc) of six nanoparticles using different compositions and formulations, as well as complete biodistribution studies in mice was done.
Lucas Torres Miranda, Sa, Marta de Souza, Albernaz, Beatriz Ferreira de Carvalho, Patricio, Mario Villela, Falcão, Bianca Feliciano, Coelho, Augusto, Bordim, Julio Cesar, Almeida, Ralph, Santos-Oliveira   +7 more
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Biodistribution of pH-sensitive immunoliposomes

Biochimica et Biophysica Acta (BBA) - General Subjects, 1986
Liposomes composed of either dioleoylphosphatidylethanolamine and oleic acid (pH-sensitive) or dioleoylphosphatidylcholine and oleic acid (pH-insensitive) were injected into C3H and Balb/c mice in order to determine the tissue distribution of both the lipid and the aqueous content.
J, Connor, N, Norley, L, Huang
openaire   +2 more sources