Results 231 to 240 of about 92,303 (298)

Red Blood Cells as Endogenous Biotweezers for Optical Micromanipulation In Vivo

Advanced Science, EarlyView.
By synergistically integrating the long‐distance manipulation fiber probe (LDMFP) and endogenous red blood cells (RBCs) as biocompatible optical elements, a natural RBC biotweezer was developed for the desired microparticle manipulation and immune cell activation within living vasculature, which might offer an alternative tool for intravital optical ...
Tong Yang, Xinyu Ren, Dalin Ma, Hao Pang, Wei Chen, Kaize Cai, Mei Yuan, Bingzhi Zhang, Zufang Lin, Xiaoshuai Liu   +9 more
wiley   +1 more source

NIS-Centered Reporter Gene Imaging and Radionuclide-Integrated Nanoplatforms for Quantitative Tracking of Immune Cell Therapy in Oncology and Inflammatory Disease Models. [PDF]

Pharmaceuticals (Basel)
Lee SB.
europepmc   +1 more source

Deep‐Learning‐Driven High‐Fidelity In Vivo Hyperspectral Fluorescence Imaging Under Extreme Photon‐Limited Conditions

Advanced Science, EarlyView.
Highly overlapping fluorescent signals become distinguishable in photon‐limited living organisms via advanced imaging with intelligent reconstruction. The resulting in vivo hyperspectral imaging capability reveals nanoplastic uptake and circulation in live zebrafish, providing a new approach for studying complex biological and environmental processes ...
Renjian Li, Shutao Wu, Kaixiang Li, Zhenyu An, Yuwen Ben, Guiye LI, Sunil Kumar, James Mcginty, Tawfique Hasan, Songnian Fu, Meng Zhang, LingLing Chen   +11 more
wiley   +1 more source

Differential expression of monoclonal antibody in rat brain following systemic and local administration of AAV. [PDF]

J Pharmacokinet Pharmacodyn
Chowdhury EA, Meno-Tetang G, Liu S, Wu S, Desireddy N, Jerez A, Mahmood L, Rajwade A, Bulusu S, Jamier T, Nucitelli A, Cusdin F, Dobson C, Shah DK.   +13 more
europepmc   +1 more source

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

Advanced Science, EarlyView.
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo, Rohit Verma, Sydney C. Nagy, Mausam Kalita, Samuel Aubert, Josué Ballesteros‐Álvarez, Pedro Machado Almeida, Hannes Vogel, Israt S. Alam, Michael Lim, Michelle L. James   +10 more
wiley   +1 more source

Biocompatible Glycoconjugation Enables Sensitive In Vivo Cell Tracking by PET/CT. [PDF]

J Med Chem
Clemons N, Thickens AS, Lambert Lepesevich L, Rosenkrans ZT, Santoro-Fernandes V, Pinchuk AN, Aluicio-Sarduy E, Mixdorf JC, D'Souza SS, Caldon J, Kink J, Forsberg MH, Hematti P, Engle JW, Slukvin I, Capitini CM, Hernandez R.   +16 more
europepmc   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

Functional Suitability Evaluation of Radioimmunoconjugates of Nanobodies against PD-L1 and HER2/neu for Tumor Theranostics. [PDF]

Sovrem Tekhnologii Med
Avrov KO, Shatik SV, Shashkova OA, Pinevich AA, Terekhina LA, Gryazeva IV, Zaitsev VV, Berlina MA, Stanzhevsky AA, Samoylovich MP.   +9 more
europepmc   +1 more source

PET Imaging of Accessible Prostate-Specific Membrane Antigen Reveals Dose-Dependent and Tumor Burden-Driven Variability. [PDF]

J Nucl Med
Mishra A, Lisok A, Mease RC, Nováková Z, Gupta K, Sharma AK, Pomper MG, Bařinka C, Nimmagadda S.   +8 more
europepmc   +1 more source

Erratum: Impact of pre-existing immunity on safety and biodistribution of a single AAV9 vector intrathecal injection in cynomolgus monkeys. [PDF]

Mol Ther Adv
Vono M, Rio TD, Magdaleno E, Loll NR, Jarvis P, Walter C, Kikkawa R, Mansfield K, McBlane F, Sirivelu MP, Ozsolak F, Brees D, Hudry E, Rubic-Schneider T, Tukov FF, Huang G.   +15 more
europepmc   +1 more source