Results 231 to 240 of about 119,908 (286)

The analysis of biodistribution and tumor uptake of [¹⁸F]AlF-FAPI-74 in patients with soft tissue sarcoma and gastro-intestinal tumors compared with [¹⁸F]FDG in a prospective, exploratory study. [PDF]

EJNMMI Rep
Novruzov E, Giesel FL, Mamlins E, Watabe T, Cardinale J, Antke C, Mori Y, Schupps N, Pinto C, Soza-Ried C, Fernandez R, Amaral H, Kramer V, Badinez L.   +13 more
europepmc   +1 more source

Tyrosinase Driven‐Intracellular Polymerization of a Porphyrin Derivative Induced Immunogenic Death of Melanoma Cells and Strengthened Photodynamic Therapy

Advanced Science, EarlyView.
This study uses tyrosinase, which is highly expressed in melanoma, to drive porphyrins to polymerize and self‐assemble within tumor cells to form retented microstructures. This process induces immunogenic death and activates immune responses (M1 macrophages, dendritic cells, CD8+T cells), turning “cold” tumors into “hot” tumors.
Mian Tang, Junteng Qiu, Yunfeng Lu, Yahui Song, Xinyu Zhou, Tianshun Duan, Xuanqi Peng, Caixia Yin, Cheng Gao, Ruibing Wang   +9 more
wiley   +1 more source

A sstR2-targeted radiohybrid theranostic agent for PET imaging and β^- therapy with excellent preclinical performance. [PDF]

Npj Imaging
Deiser S, Fenzl S, König V, Inoue S, Casini A.   +4 more
europepmc   +1 more source

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

Safety, efficacy, and distal nerve Schwann cell biodistribution in mice and NHPs to support translation of AAV9 RNAi therapy for CMT1A. [PDF]

Mol Ther Nucleic Acids
Stavrou M, Wallace LM, Thangaraj MP, Taylor NK, Kagiava A, Papacharalambous R, McAllister C, Zender G, Saad NY, Bayazit MB, Heslegrave A, Tryfonos C, Richter J, Zetterberg H, Price B, Salzman R, Kleopa KA, Harper SQ.   +17 more
europepmc   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Should patients with pre-existing anti-AAV antibodies be excluded from receiving intrathecally delivered AAV vectors? [PDF]

Mol Ther Methods Clin Dev
Gray SJ.
europepmc   +1 more source

T Cell‐Independent Role of PD‐L1 in Kidney Repair: Mitigation of Tubular DNA Damage via PD‐L1/BRCA1 Interaction Following AKI

Advanced Science, EarlyView.
PD‐L1 is primarily expressed in renal tubules and upregulated in both murine models of AKI and renal biopsy samples from patients with AKI. PD‐L1 can promote adaptive TECs repair through interacting with BRCA1, independent of its canonical immunomodulatory function of T cells, and PD‐L1 supplementation may represent a promising therapeutic strategy for
Wei Jiang, Tao‐Tao Tang, Wei‐Jie Ni, Jin‐Xuan Wei, Liang‐Yun‐Zi Jiang, Qing Yin, Yi‐Lin Zhang, Zuo‐Lin Li, Yi Wen, Xin‐Lu Wang, Jun‐Yuan Shen, Xiao‐Jun Ouyang, Ming‐Zhu Zheng, Jian Xu, Xiaofei An, Lin‐Li Lv, Bi‐Cheng Liu, Bin Wang   +17 more
wiley   +1 more source

Chelator Conjugation Chemistry Matters: Squaramide Linker Enhances Tumor Contrast in ⁶⁸Ga-labeled Anti-CEA Nanobody Tracer. [PDF]

ACS Omega
Saliën J, Floru S, Van Hove M, De Pauw T, Vizier R, Claron M, Bridoux J, Goncalves V, Denat F, Hernot S.   +9 more
europepmc   +1 more source