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Assessments of antibody biodistribution
The Journal of Clinical Pharmacology, 2015AbstractMonoclonal antibody (mAb) therapeutics are in use for several disease conditions, and have generally shown excellent clinical benefit, in large part due to their high specificity and affinity for target proteins. As this therapeutic class continues to grow in size, improved understanding of the mechanisms controlling mAb biodistribution and ...
Patrick M, Glassman +2 more
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Altered Biodistribution of 68Ga-DOTATOC
Clinical Nuclear Medicine, 2020Abstract 68Ga-DOTATOC PET/CT of a patient with metastatic neuroendocrine tumor reveals an abnormal biodistribution of the tracer with a vascular binding and a very low fixation on the known lesions despite the temporary discontinuation of “cold” somatostatin analogs.
Anne-Claire, Dupont +4 more
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In Vivo Bacteriophage Biodistribution
2017At the dawn of the renaissance of bacteriophage therapy, the full acceptation of bacteriophages as anti-bacterial agents requires the determination of their basic pharmacokinetic parameters. Such data, known for all conventional drugs used in human and veterinary medicine, allow optimizing dose regimens, efficacy, and help to limit toxicity.
Dufour, Nicolas +2 more
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Bioconjugation and biodistribution
2002The term “bioconjugation ” usually defines the specific covalent linking between two biomolecules, in order to obtain a novel molecular entity with peculiar physicochemi-cal and biological properties (1). In medicine, bioconjugation is mainly exploited to impart biological specificity to drugs or diagnostics.
VERONESE F.M., CALICETI, PAOLO
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Biodistribution of phosphodiester and phosphorothioate siRNA
Bioorganic and Medicinal Chemistry Letters, 2004Short interfering RNAs (siRNAs) are valuable tools for analyzing protein function in mammalian cell culture. This success has led to high expectations for in vivo and therapeutic applications. However, the pharmacokinetic properties of siRNA are not known.
Ralph Mason, David R Corey, Orhan Oz
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Biodistribution of nanoparticles: Initial considerations
Journal of Pharmaceutical and Biomedical Analysis, 2012Nanotechnology is attracting increasing attention worldwide. This study was made use of modern technology to decipher most of the intriguing biological aspects of nanoparticles. Labeling with technetium-99m ((99m)Tc) of six nanoparticles using different compositions and formulations, as well as complete biodistribution studies in mice was done.
Lucas Torres Miranda, Sa +7 more
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Biodistribution of Radiolabeled Ethanol in Rodents
Drug Metabolism and Disposition, 2008The biodistribution of [1-(14)C]ethanol in rodents was examined to determine sites of concentration of ethanol or its metabolites that may contribute to its toxicological and pharmacokinetic characteristics. After i.v. administration of [1-(14)C]ethanol in mice, radioactivity showed a widespread distribution among body organs.
Andrew N, Gifford +2 more
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Biodegradation, biodistribution and toxicity of chitosan
Advanced Drug Delivery Reviews, 2010Chitosan is a natural polysaccharide that has attracted significant scientific interest during the last two decades. It is a potentially biologically compatible material that is chemically versatile (-NH2 groups and various M(w)). These two basic properties have been used by drug delivery and tissue engineering scientists to create a plethora of ...
Kean, T., Thanou, M.
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In VivoBiodistribution of Nanoparticles
Nanomedicine, 2011Nanoparticles have potential applications in diagnostics, imaging, gene and drug delivery and other types of therapy. Iron oxide nanoparticles, gold nanoparticles and quantum dots have all generated substantial interest and their properties and applications have been thoroughly studied. Yet, metal-containing particles raise biodistribution and toxicity
Joao Paulo Mattos, Almeida +3 more
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Biodistribution of pH-sensitive immunoliposomes
Biochimica et Biophysica Acta (BBA) - General Subjects, 1986Liposomes composed of either dioleoylphosphatidylethanolamine and oleic acid (pH-sensitive) or dioleoylphosphatidylcholine and oleic acid (pH-insensitive) were injected into C3H and Balb/c mice in order to determine the tissue distribution of both the lipid and the aqueous content.
J, Connor, N, Norley, L, Huang
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